PhD. Topics
Biomedical Research Center SAS
Topic
Extracellular vesicles as modulators of systemic and tissue-specific metabolic flexibility: the impact of exercise and complex lifestyle modification in patients with obesity
PhD. program
biochemistry
Name of the supervisor
Mgr. Jozef Ukropec, DrSc.
Contact:
Receiving school
Faculty of Natural Sciences, Comenius University
Annotation
Obesity is the leading risk factor of a spectrum of chronic diseases, highly prevalent in Slovak population. Metabolic flexibility is an important determinant of the whole-body metabolic health with the capacity to modulate effectiveness of the response to exercise & lifestyle interventions. Lifestyle modification is a cornerstone of obesity management, and aim of this work is to characterize the clinical parameters and molecular biomarkers of metabolic flexibility contained in exosomes released in energetically challenging situations. Ultimately, we would like to define and validate a biomarker predicting the response to a lifestyle intervention, which would allow presonalised precission medicine for obesity and obesity associated chronic diseases, including metabolic and neurodegenerative diseases.