PhD. Topics
Biomedical Research Center SAS
Topic
Study of tick-borne encephalitis virus - host interactions in the skin ex vivo
PhD. program
molecular biology
Name of the supervisor
Mgr. Pavlína Bartíková, PhD.
Contact:
Receiving school
Faculty of Natural Sciences, Comenius University
Annotation
It is generally known that tick-borne encephalitis virus is neurotropic and the most common way to get infection is through biting of infected ticks. Thus, the outcome of the infection is influenced by the interactive events between ticks, virus and the host in the skin. However, information about them is very scarce. Using human skin ex vivo model can help to understand and elucidate some of the molecular mechanisms of infection in the skin and fill in some missing puzzle pieces to the knowledge of the complexity of virus – host.
Aims of thesis:
to establish cultivation of human skin explants in our laboratories; to set up appropriate infection; observation, exploration and comparative analysis of mutual interactions – replication and spread of virus versus innate immune response in skin explants after infection
Aims of thesis:
to establish cultivation of human skin explants in our laboratories; to set up appropriate infection; observation, exploration and comparative analysis of mutual interactions – replication and spread of virus versus innate immune response in skin explants after infection