Information Page of SAS Organisation

Institute of Measurement Science

International projects

Preparation and study of the precursor properties for development of nanomaterials based on metal oxides
Príprava a štúdium vlastností prekurzorov pre vývoj nanomateriálov na báze oxidov kovov
Program: Bilaterálne - iné
Project leader: RNDr. Cigáň Alexander CSc.
Annotation:The subject of common interest include the following main areas: 1.Technology of HTc superconducting oxides based on Yttrium, Bismuth, Thalium and Mercury - bulks, tapes and thin films. 2.Investigation of the physical properties of these materials with the help of magnetization measurements. 3.Common experiments performed with LTc SQUID gradiometric system (at IMS SAS, Bratislava) and LakeShore susceptometer (at the Department of Inorganic and Physical Chemistry, Ghent). 4.Publication of results on cooperative scientific activities.
Duration: 1.7.2016 - 31.12.2020


National projects

Analysis of causal relationships in complex systems with an emphasis on biomedical applications
Analýza kauzálnych vzťahov v zložitých systémoch s dôrazom na biomedicínske aplikácie
Program: VEGA
Project leader: RNDr. Krakovská Anna CSc.
Annotation:The project is focused on the analysis of causal relationships in complex systems, with particular applications in the field of biomedicine. Its main task is to verify the practical applicability of recently proposed methods, and to propose new algorithms to detect the presence and direction of the causal links (in the sense of Granger's definition). Existing, often fundamentally different approaches to detect causality will be analysed, tested on computer-generated systems and modified. The resulting methodology will be used for the analysis of real systems. The main application area is functional brain connectivity, detected in different contexts from EEG signals and their inverse cortical mapping. Applications will also concern other types of physiological signals and experimental time series.
Duration: 1.1.2016 - 31.12.2018

FYZKUL - Physical non-destructive methods for complex testing and analysis of cultural heritage artefacts.
Fyzikálne nedeštruktívne metódy pre komplexné testovanie a analýzu artefaktov kultúrneho dedičstva.
Program: APVV
Project leader: RNDr. Hain Miroslav PhD.
Annotation:The project deals with the use of the state of the art non-destructive physical methods and devices for analyzing and testing of objects of tangible cultural heritage. Among the comprehensive research methods the X-ray microtomography, X-ray microscopy, scanning electron microscopy, energy-dispersive X-ray spectrometry, ultraviolet fluorescence, infrared reflectography, FTIR spectroscopy, UV, VIS, NIR spectroscopy and active infrared thermography will be used. The project aims to achieve a synergistic effect when information about the artefact derived from different physical measurement methods and subsequently processed and evaluated together will provide qualitatively new comprehensive information on the historical artefact under study.
Duration: 1.7.2015 - 30.6.2019

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Meracie a zobrazovacie metódy na báze magnetickej rezonancie pre materiálový a biomedicínsky výskum
Program: VEGA
Project leader: Ing. Andris Peter PhD.
Duration: 1.1.2017 - 31.12.2019

Measurement of biological response to weak low-frequency electromagnetic fields
Meranie biologickej odozvy slabých nízkofrekvenčných elektromagnetických polí
Program: VEGA
Project leader: Mgr. Teplan Michal PhD.
Annotation:Research topic is based on the perspective of electromagnetic (EM) principles of living system operation. The overall objective of the research is to expand knowledge of the impact of weak external low frequency EM fields on functioning of selected biological objects. The main aim of the research is to design a new experimental approach enabling efficient scanning through EM fields parameters, while searching for specific resonance response of investigated biosystem. Methods based on the impedance spectroscopy will be developed in order to determine the response in a form of shifted growth rate of cell cultures in an aqueous medium. The morphology and kinetics of the cells will be studied by image analysis obtained from a video-microscopy. The results will be analyzed for their possible applications in emergent problems of contemporary society.
Duration: 1.1.2016 - 31.12.2018

Modeling of cardiac electrical field for the study of manifestation of funtional and structural changes in myocardium in measured ECG signals
Modelovanie elektrického poľa srdca na výskum prejavov funkčných a štrukturálnych zmien myokardu v meraných EKG signáloch
Program: VEGA
Project leader: Ing. Švehlíková Jana PhD.
Annotation:The aim of the project is to gain new knowledge about the relation between the electrical activation of the ventricular myocardium and the surface electrocardiogram that can be obtained by a multichannel measurement. The results will be a part of the evidence being prepared by the International Working Group on ECG Diagnostics of the Left Ventricular Hypertrophy for principal change of the diagnostic paradigm. The model of heart ventricles created in previous VEGA projects will be extended and possibilities to change the velocity of propagation of the activation wavefront and the model geometry, and anisotropic properties of the activation wavefront propagation will be added. The model will be implemented in software with graphical user interface. Besides its usage in the research of the impact of changes in the myocardium on the measured ECG signals, it will be available also as a didactic tool. The model will be used also in inverse problem solution using dipole generators or probabilistic models.
Duration: 1.1.2016 - 31.12.2018

Morfology of fossil lizards using micro-computed tomography, their phylogeny, paleobiogeography - migrations and faunal changes during the climatic changes of Cenozoic
Morfológia fosílnych jašterov s použitím zobrazovacích techník počítačovej mikrotomografie, ich fylogenetické vzťahy, paleobiogeografia - migrácie a zmeny spoločenstiev odrážajuce postupné klimatické zmeny kenozoika
Program: VEGA
Project leader: RNDr. Hain Miroslav PhD.
Annotation:Project deals with new, in most cases complete finds of lizards from the Cenozoic, which is a period characterized by marked global climate changes. The aim is the anatomical research of fossil and modern animals using micro-CT.
Duration: 1.1.2018 - 31.12.2020

METSTAT - Advanced statistical and computational methods for measurement and metrology
Pokročilé štatistické a výpočtové metódy pre meranie a metrológiu
Program: APVV
Project leader: Doc. RNDr. Witkovský Viktor CSc.
Annotation:The aim of the project is to develop mathematical and statistical methods and algorithms for evaluation of the measurement results with emphasis on the development of models and methods for multivariate calibration of measuring devices and methods and algorithms for determining the uncertainties in measurement by deriving the exact resp. approximate probability distributions of the measurement results. Research will focus primarily on the following areas: • Theoretical research on mathematical and statistical models and methods for multivariate calibration; • Development of calibration theory of the sensors and transducers, uncertainty determination in calibration of sensor under the normally distributed measurement errors as well as under the alternative probability distributions of measurement errors, development of procedures for calibration and measurement evaluation useful in laboratory work, evaluation of sensor calibration in the thermal and mechanical quantities with continuous scale (pressure transmitter, thermocouple temperature sensors , resistance thermometers, etc.), and determination of the calibration values of the physico-chemical parameters by using the certified reference materials; • Development of methods and algorithms to determine the exact resp. approximate probability distribution of measurement results by combining and inverting the characteristic functions of the probability distributions of the input variables and characterizing uncertainty in metrology. The application of the mathematical, statistical, and computational methods for the measurement science and metrology is high on the agenda, with a significant impact on the international scientific as well as industrial cooperation and economic growth in developed countries. It is in good agreement with the intentions of the strategy for research and development, approved by the Slovak government (SK RIS3).
Duration: 1.7.2016 - 30.6.2020

Effect of ultrasmall superparamagnetic iron oxide nanoparticles on the cardiovascular system of rats with high blood pressure
Vplyv ultra malých superparamagnetických nanočastíc železa na kardiovaskulárny systém potkana v podmienkach vysokého krvného tlaku
Program: VEGA
Project leader: Ing. Maňka Ján CSc.
Annotation:This project will investigate the effect of ultrasmall superparamagnetic iron oxide nanoparticles (USPIONs) on function and structure of the arterial wall and the heart in rats with high blood pressure. We will investigate if acute stress and chronic high blood pressure can facilitate the USPIONs uptake in the arterial wall and heart, to modify cardiovascular function, including blood pressure regulation and to induce metabolic disorders, oxidative damage and alterations of the Fe2+/Fe3+ ratio in the heart and vasculature. We will investigate if L-type of voltage-dependent calcium channels is involved in iron uptake after USPIONs treatment. Results achieved in this project will contribute to better understanding of USPIONs effects on the cardiovascular system in conditions of acute stress and high blood pressure as well as on prevention of cardiovascular risk resulting from the use of USPIONs in targeted drug delivery.
Duration: 1.1.2017 - 31.12.2020

ECoReMiR - Enhancing cognition and motor rehabilitation using mixed reality
Vylepšovanie kognície a motorickej rehabilitácie s využitím zmiešanej reality
Program: APVV
Project leader: Ing. Mgr. Rosipal Roman PhD.
Annotation:Technological advancements based on mixed reality (MR) offer various challenges for research and medical treatment. The project focuses on two objectives related to healthy subjects and hemiparetic patients after stroke. First, we will test the hypothesis whether cognitive training using appropriately designed MR environment will enhance perceptual and cognitive performance in healthy subjects. This will be tested by computerized psychological experiments as well as by measuring event-related potentials or ERPs. Second, we will test the hypothesis whether experience with training in MR (in combination with motor-imagery based brain-computer interface developed by us) will enhance oscillatory sensory-motor rhythms. This will be tested by measuring subject’s EEG activity before and after each training session, clinical testing, as well as by the questionnaires aiming to learn about human factors including mental fatigue, motivation, irritation or sleepiness due to training. In both objectives, we will design and implement a set of testing procedures, carry out a battery of dedicated experiments, and critically evaluate the results with the goal to validate MR designs.
Duration: 1.7.2017 - 30.6.2021

KompMag - Research of comparative imaging methods based on magnetic resonance for diagnostics of neurological and musculoskeletal diseases
Výskum komparatívnych zobrazovacích metód na báze magnetickej rezonancie na diagnostiku neurologických a muskuloskeletálnych ochorení
Program: APVV
Project leader: Prof. Ing. Frollo Ivan DrSc.
Annotation:Intense development of the imaging methods based on magnetic resonance using up-to-date technical equipment - NMR tomographs gives extraordinary chance to the basic research aspects of this scientific orientation. Modern MR open scanners with ability to develop own sequences allow for wide basic research of imaging,measurement and mapping of the specific physical quantities and object for improvement of biomedical and material research with clinical applications. The main goal of this project proposal will be the design of progressive comparative MRI imaging methods using the whole range of MRI scanners (0.1, 0.2, 4.7 to 7 Tesla) with special focus on: - theoretical and experimental investigation of scanning approaches measurement and mapping of specific physical quantities of the organic and synthetic materials, - in-vivo an in-vitro imaging of ferritin at different MR scanners, sequence development, data processing and investigation of the ferritin influence on MR image. Imaging of the tissues (brain, liver) and protocol standardization for imaging of ferritin in the clinical practice, - methods of cartilage and meniscus imaging - the early diagnostics of connective tissue depletion, relaxation times mapping for collagen structure assessment, - monitoring of particle deposition as drug carriers to target tissues in the form of superparamagnetic material. The investigation of the possible targeting using gradient magnetic fields, - investigation of artefacts with various sequences, testing of the spectral properties of vibrations and noise generated by gradients activity; development, application and testing algorithms for their effect compensation. Additionally, the add on value will be the non-invasive nature of all methods which will be beneficial for early diagnostics of pathological processes in medical research and also in clinical practice.
Project web page:http://www.um.sav.sk/sk/oddelenie-04/vyskum-komparativnych-zobrazovacich-metod-na-baze-magnetickej-rezonancie-na-diagnostiku-neurologickych-a-muskuloskeletalnych-och.html
Duration: 1.7.2016 - 30.6.2019

RIDD - Research of magnetic forms of iron in development of cardiovascular diseases and behavioural disorders
Výskum magnetických foriem železa v rozvoji kardiovaskulárnych chorôb a porúch správania
Program: APVV
Project leader: Ing. Maňka Ján CSc.
Annotation:This project proposal is focused on the investigation of the role of iron in development of cardiovascular and behavioural disorders, prevalence of which is increasing during aging. The aim of this project is to investigate the impact of aging on the metabolism of biogenic iron and its magnetic properties in association with metabolic and functional alterations in the cardiovascular system and brain in rats with various genetic predispositions to hypertension. We will determine the molecular biological changes on the level of gene expression, their encoded proteins and the activities of the enzymes involved in the endogenous antioxidant protection, the regulation of nitric oxide production and cell death due to ferroptosis in course of aging. We will also investigate the impact of exogenously administered iron in the form of the biocompatible ultrasmall superparamagnetic iron oxide nanoparticles (USPIONs) on blood pressure regulation and function of the heart and blood vessels in conditions of normotension, chronically increased blood pressure and acute stress (i.e. acutely elevated blood pressure). Results achieved in this project will contribute to better understanding of the effects of the altered iron metabolism, magnetic forms of bodily iron, as well as iron in the form of USPIONs, on the cardiovascular and central nervous systems and to prevention of cardiovascular risk resulting from the use of USPIONs in targeted drug delivery or as the contrast materials for new imaging methods in medicine.
Project web page:http://www.bionanoiron.sav.sk/
Duration: 1.7.2017 - 30.6.2021

Research on possibilities and development of SQUID magnetometry for selected applications in biomedicine and material research
Výskum možností a rozvoj SQUID magnetometrie pre vybrané aplikácie v biomedicíne a materiálovom výskume
Program: VEGA
Project leader: Ing. Maňka Ján CSc.
Annotation:Project has an interdisciplinary character.The aim is to show the possibilities of use of the SQUID magnetometry in study of the actual processes in medicine, biology and material research: -in analysis of the properties and magnetic characterization of the nanoparticles and nanoliquids, especially ultra-small superparamagnetic nanoparticles based on iron oxides (USPIONs) -in investigation of the influence of the USPIONs on the function and structure of the blood vessels and heart, on development of the oxidative damage and in study of processes of the USPIONs transport through cell membranes, blood vessels and organs of rats with normal and high blood pressure -in development of the procedures and methods of quantification of the magnetic substances content in the human and animal cell cultures and organs - in study and development of the aluminate glasses with photoluminescence properties - in development of new 2D materials, MXenes, exfoliated transition metal carbides and carbonitrides
Duration: 1.1.2017 - 31.12.2020

Projects total: 13