In: NEOPLASMA, vol. 55, no. 6
M. Rydzanicz - M. Giefing - A. Ziolkowski - M. Kasprzyk - A. Gabriel - W. Dyszkiewicz - K. Szyfter
Detaily:
Rok, strany: 2008, 493 - 500
O článku:
Lung cancer is one of the most common malignancies and cancer-related death worldwide. Lymph node metastasis is the
main cause of treatment failure. Although many studies were performed to evaluate genetic events associated with development
and progression of lung cancer, molecular mechanism still remains poorly defined.
In the present study, using comparative genomic hybridization (CGH) technique, we described the pattern of DNA copy
number changes in a cohort of 42 primary squamous cell carcinomas (SCC) of the lung. A direct comparison of nonmetastatic
(TxN0M0) and metastatic (TxN1-2M0) tumors was performed to define chromosomal imbalances related to lymph
node metastases.
Some genetic alterations were observed more frequently in metastatic than in non-metastatic tumors, including losses at
11q, 16p, 16q, 19p and gains at 4q, 7q, 12p, 13q, 18p. The gain at 7q with the smallest common altered region 7q31.2-q32,
was found to be directly associated with lymph node involvement (p=0.0407). We suggest that the established chromosomal
region harbors two putative tumor suppressor genes WNT2 and c-Met. An overexpresion of these genes seems to be involved
in inducing the invasive growth and metastatic potential of SCC of the lung.
Key words: Squamous cell lung cancer, lymph node metastases, comparative genomic hybridization, gain at 7q31.2-q32,
WNT2, c-Met
Ako citovať:
ISO 690:
Rydzanicz, M., Giefing, M., Ziolkowski, A., Kasprzyk, M., Gabriel, A., Dyszkiewicz, W., Szyfter, K. 2008. Nonrandom DNA copy number changes related to lymph node metastases
in squamous cell carcinoma of the lung. In NEOPLASMA, vol. 55, no.6, pp. 493-500. 0028-2685.
APA:
Rydzanicz, M., Giefing, M., Ziolkowski, A., Kasprzyk, M., Gabriel, A., Dyszkiewicz, W., Szyfter, K. (2008). Nonrandom DNA copy number changes related to lymph node metastases
in squamous cell carcinoma of the lung. NEOPLASMA, 55(6), 493-500. 0028-2685.