In: NEOPLASMA, vol. 54, no. 4
P. Plevova - J. Bouchal - M. Fiuraskova - L. Foretová - M. Navrátilová - J. Zapletalová - R. Čuřík - O. Prokop - Z. Kolar
Detaily:
Rok, strany: 2007, 263 - 268
O článku:
The PML protein is concentrated in the PML nuclear bodies. Downregulation of the PML protein has been described in
various types of cancer and is in accordance with the fact that dysqualification of tumor suppressive functions of the PML
protein might promote cancer development. Various differences have been described between sporadic breast cancer and
that associated with BRCA1 and BRCA2 gene mutations. Expression of the PML protein has not been studied yet. The aim
of this study was to determine if there is any difference in PML protein expression in breast cancer of BRCA1 and BRCA2
gene mutation carriers compared to sporadic breast cancer and if the PML protein can be used as a prognostic marker. There
were 47 breast cancer samples included, 14 and 10 from BRCA1 and BRCA2 germline mutation carriers, respectively, and 23
from patients without a BRCA1/BRCA2 germline mutation. Immunofluorescence staining was used. Downregulation of
PML protein expression was found in 2 of 14 (14%), 3 of 10 (30%) and 15 of 47 (31%) cases of breast cancer samples from
BRCA1, BRCA2 and no BRCA1/BRCA2 mutation carriers, respectively (pBRCA1 = 0.019; pBRCA2 = 0.111). There was no correlation
between PML protein expression and age, histological types, estrogen and progesteron receptor, c-erbB-2 and PCNA
expression, TNM classification, disease-free and overall survival. In conclusion, the PML protein is downregulated in
approximately 30% of breast cancers cases. Downregulation of PML protein expression was significantly less frequent in
BRCA1 mutation carriers compared to sporadic cases. No correlation was found between PML protein expression and any of
the other clinical and laboratory characteristics.
Key words: PML protein; BRCA1 gene; BRCA2 gene; breast cancer
Ako citovať:
ISO 690:
Plevova, P., Bouchal, J., Fiuraskova, M., Foretová, L., Navrátilová, M., Zapletalová, J., Čuřík, R., Prokop, O., Kolar, Z. 2007. PML protein expression in hereditary and sporadic breast cancer. In NEOPLASMA, vol. 54, no.4, pp. 263-268. 0028-2685.
APA:
Plevova, P., Bouchal, J., Fiuraskova, M., Foretová, L., Navrátilová, M., Zapletalová, J., Čuřík, R., Prokop, O., Kolar, Z. (2007). PML protein expression in hereditary and sporadic breast cancer. NEOPLASMA, 54(4), 263-268. 0028-2685.