In: NEOPLASMA, vol. 53, no. 3
E. Jabłonska - W. Puzewska - M. Charkiewicz
Detaily:
Rok, strany: 2006, 200 - 205
O článku:
The inducible synthase of nitric oxide (iNOS) is responsible for
the synthesis of nitric oxide (NO) in neutrophils (PMN)
and in peripheral blood mononuclear cells (PBMC). This enzyme is
controlled by a number of cytokines which accomplish
their biological effect via e.g. activation of NF-kB pathway.
The aim of the present study was to assess the expression of iNOS
and production of NO by PMN and PBMC in patients
with oral cavity squamous cell carcinoma (SCC), and to examine the
role of the NF-kB pathway in the IL-18-stimulated activation
of this enzyme.
The production of NO and iNOS expression in PMN were reduced,
while iNOS expression in PBMC was increased but
NO production by these cells remain unchanged. Patients after
treatment showed lower intensity of iNOS expression compared
to that observed before treatment. Moreover, both before and after
treatment iNOS expression was inversely correlated
with phospho-IkB expression in PMN and in PBMC.
Significantly higher levels of total NO were observed in the serum
of Stage IV patients before and after treatment as compared
to the control group.
Altered expression of iNOS and NO generation by PMN and PBMC may
have an unfavorable effect on the course of
antineoplastic response in patients with squamous cell carcinoma
of the oral cavity. Intensification of iNOS expression and
NO production in Stage IV patients, induced by rhIL-18, suggests
its beneficial effect on the activity of leukocytes in patients
with squamous cell carcinoma of the oral cavity.
Ako citovať:
ISO 690:
Jabłonska, E., Puzewska, W., Charkiewicz, M. 2006. Effect of IL-18 on leukocyte expression of iNOS and phospho-IkB in patients with squamous cell carcinoma of the oral cavity. In NEOPLASMA, vol. 53, no.3, pp. 200-205. 0028-2685.
APA:
Jabłonska, E., Puzewska, W., Charkiewicz, M. (2006). Effect of IL-18 on leukocyte expression of iNOS and phospho-IkB in patients with squamous cell carcinoma of the oral cavity. NEOPLASMA, 53(3), 200-205. 0028-2685.