In: NEOPLASMA, vol. 52, no. 6
G. Momekov - A. Bakalova - S. Konstantinov - D. Todorov - M. Karaivanova
Detaily:
Rok, strany: 2005, 469 - 475
O článku:
The cytotoxic effects of a series of carboxylato-bridged dinuclear
platinum (II) complexes with acetate (BAP), propionate
(BPP) and valerate (BVP) ligands were evaluated in a panel of
human tumor cell lines. BAP proved to be the most potent
antineoplastic agent, whose cytotoxic effect reached and even
outclassed that of the referent drug cisplatin. This compound
also exerted substantial efficacy against a broader spectrum of
tumor models including the multidrug-resistant
HL-60/Dox cell line. In the latter case, BAP showed lower
resistance index than cisplatin. BAP was furthermore found to
induce
apoptosis in different cell lines as evidenced by DNA-laddering
and ´Cell-death´ ELISA. Our experimental data give
us reason to conclude that the dinuclear Pt(II) complex with
acetate ligands is perspective for further detailed pharmacological
and toxicological evaluation as an antineoplastic drug candidate.
Ako citovať:
ISO 690:
Momekov, G., Bakalova, A., Konstantinov, S., Todorov, D., Karaivanova, M. 2005. Comparative assessment of the cytotoxic effects of carboxylato-bridged dinuclear platinum (II) complexes against human tumor cell lines. In NEOPLASMA, vol. 52, no.6, pp. 469-475. 0028-2685.
APA:
Momekov, G., Bakalova, A., Konstantinov, S., Todorov, D., Karaivanova, M. (2005). Comparative assessment of the cytotoxic effects of carboxylato-bridged dinuclear platinum (II) complexes against human tumor cell lines. NEOPLASMA, 52(6), 469-475. 0028-2685.