In: NEOPLASMA, vol. 52, no. 3
B.a. Zachara - K. Szewczyk-Golec - J. Tyloch - Z. Wolski - T. Szylberg - S. Stepien - S. Kwiatkowski - E. Bloch-Boguslawska - W. Wasowicz
Detaily:
Rok, strany: 2005, 248 - 254
O článku:
Prostate cancer (PC) is the most common cancer in men and a
leading cause of cancer death. Prostatic gland accumulates
reasonably high amount of selenium (Se), the element that prevents
the development of PC. It is hypothesized that some
selenoproteins inhibit the transformation of normal prostate
epithelium into neoplasm.
We studied Se levels in whole blood, plasma and prostate of 32 PC
and 40 benign prostate hyperplasia (BPH) patients and
in the control group composed of 39 healthy subjects. The
selenoenzyme glutathione peroxidase (GSH-Px) was also measured
in the patients' red cells, plasma and prostate tissue.
Se concentration in whole blood and plasma in both groups of
patients was lower as compared with controls, while in
prostate gland it was significantly higher in PC than in BPH
patients and controls. Red cell GSH-Px activity was the same in
PC patients and controls but significantly lower in BPH patients.
Plasma GSH-Px activity was significantly lower in PC patients
than in the control group, and prostate GSH-Px activity was
significantly lower in PC patients as compared with BPH
patients.
Since Se has anticancer properties, it is very likely that its low
level in blood may facilitate the development of cancer.
A higher level of Se in prostate of PC patients has no influence
on GSH-Px activity in the gland.
Ako citovať:
ISO 690:
Zachara, B., Szewczyk-Golec, K., Tyloch, J., Wolski, Z., Szylberg, T., Stepien, S., Kwiatkowski, S., Bloch-Boguslawska, E., Wasowicz, W. 2005. Blood and tissue selenium concentrations and glutathione peroxidase
activities in patients with prostate cancer and benign prostate
hyperplasia. In NEOPLASMA, vol. 52, no.3, pp. 248-254. 0028-2685.
APA:
Zachara, B., Szewczyk-Golec, K., Tyloch, J., Wolski, Z., Szylberg, T., Stepien, S., Kwiatkowski, S., Bloch-Boguslawska, E., Wasowicz, W. (2005). Blood and tissue selenium concentrations and glutathione peroxidase
activities in patients with prostate cancer and benign prostate
hyperplasia. NEOPLASMA, 52(3), 248-254. 0028-2685.