Complications and mortality of surgical therapy for esophageal cancer: 10 years single center experience

Rok, strany: 2018, 799 - 806

A single-center retrospective study the complication and mortality of surgical treatment of esophageal cancer 2006 to 2015 is presented. A total of 212 patients with esophageal cancer were operated at the First Department of Surgery University Hospital Olomouc, Czech Republic in the period between 2006 and 2015. Adenocarcinoma was histologically described in 127 patients (59.9%), squamous cell carcinoma in 82 patients (38.7%), and other types of carcinoma were described in 3 cases. According to the preoperative staging of esophageal cancer, the patients with early stage disease (T1-2N0M0) had primary surgery, while the patients with advanced stage (T3-4N0-2M0) were indicated for neoadjuvant chemoradiation with the surgery being performed subsequently. Transhiatal laparoscopic esophagectomy was performed in 183 patients, and Orringer esophagectomy in 4 patients. Thoracoscopic esophagectomy was performed in 17 patients and thoracotomy in 30 patients. Respiratory failure with the development of ARDS syndrome accompanied by multiple-organ failure occurred in 21 patients. Statistically significant association between mortality and ASA (p = 0.009) and between respiratory complications and ASA (p = 0.006) was demonstrated. The majority of patients who died were under 60 years of age (p = 0.039). Further, significant association between 30-day mortality and tumor stage (p = 0.021), gender (p = 0.022) and age (p = 0.018) was evident. A significant association between tumor stage and fistula in anastomosis, (p = 0.043) was observed. Esophagectomy is a procedure, which should be performed in specialized high-volume centers experienced in treatment of this serious malignancy and by certified oncology surgeons with long time experience in esophageal surgery.

ISO 690:

Vrba, R., Vrana, D., Neoral, C., Aujesky, R., Stasek, M., Bohanes, T., Tesarikova, J., Cincibuch, J., Melichar, B., Horakova, M., Zapletalova, J. 2018. Complications and mortality of surgical therapy for esophageal cancer: 10 years single center experience. In NEOPLASMA, vol. 65, no.5, pp. 799-806. 0028-2685.

APA:

Vrba, R., Vrana, D., Neoral, C., Aujesky, R., Stasek, M., Bohanes, T., Tesarikova, J., Cincibuch, J., Melichar, B., Horakova, M., Zapletalova, J. (2018). Complications and mortality of surgical therapy for esophageal cancer: 10 years single center experience. NEOPLASMA, 65(5), 799-806. 0028-2685.