In: General Physiology and Biophysics, vol. 36, no. 1
Ra Lee - Young-Joo Jeon - Jin Cho - Jeong-Yun Jang - Il-Keun Kong - , Seok-Ho Kim - Minseok Kim - Hak-Jae Chung - Keon Oh - Seon-Min Park - Jae-Cheon Shin - Jae-Min Seo - Sungho Ko - Jung-Hyun Shim - Jung-Il Chae
Detaily:
Rok, strany: 2017, 31 - 39
O článku:
Esculetin, a coumarin derivative, is a phenolic compound isolated from Artemisia capillaris, Citrus limonia, and Euphorbia lathyris. Although it has been reported to have anti-inflammatory, anti-oxidant, and anti-proliferative activities in several human cancers, its anti-proliferative activity against non-small-cell lung carcinoma (NSCLC) and the molecular mechanisms involved have not been adequately elucidated. In this study, we used two NSCLC cell lines (NCI-H358 and NCI-H1299) to investigate the anti-proliferative activity and apoptotic effect of esculetin. Our data showed that esculetin-treated cells exhibited reduced proliferation and apoptotic cell morphologies. Intriguingly, the transcription factor specificity protein 1 (Sp1) was significantly suppressed by esculetin in a dose- and time-dependent manner. Furthermore, the levels of p27 and p21, two key regulators of the cell cycle, were up-regulated by the esculetin-mediated down-regulation of Sp1; the level of a third cell-cycle regulator, survivin, was decreased, resulting in caspase-dependent apoptosis. Therefore, we conclude that esculetin could be a potent anti-proliferative agent in patients with NSCLC.
Ako citovať:
ISO 690:
Lee, R., Jeon, Y., Cho, J., Jang, J., Kong, I., Kim, ,., Kim, M., Chung, H., Oh, K., Park, S., Shin, J., Seo, J., Ko, S., Shim, J., Chae, J. 2017. Esculetin exerts anti-proliferative effects against non-small-cell lung carcinoma by suppressing specificity protein 1 in vitro. In General Physiology and Biophysics, vol. 36, no.1, pp. 31-39. 0231-5882.
APA:
Lee, R., Jeon, Y., Cho, J., Jang, J., Kong, I., Kim, ,., Kim, M., Chung, H., Oh, K., Park, S., Shin, J., Seo, J., Ko, S., Shim, J., Chae, J. (2017). Esculetin exerts anti-proliferative effects against non-small-cell lung carcinoma by suppressing specificity protein 1 in vitro. General Physiology and Biophysics, 36(1), 31-39. 0231-5882.