In: NEOPLASMA, vol. 53, no. 3
J. Prausová - R. Lohynská - K. Kubáčková - Z. Linke - B. Malinová - E. Kubala - J. Novotný Jr
Detaily:
Rok, strany: 2006, 263 - 268
O článku:
The aim of presented study was to evaluate the impact of different
factors on survival, local recurrence and development
of metastatic disease in patients with rectal cancer treated with
preoperative radiotherapy or 5-fluorouracil (5-FU) based
concurrent chemoradiation. Retrospective clinical evaluation was
performed in 165 patients (33% women and 67% men)
with locally advanced rectal adenocarcinoma treated with
preoperative radiotherapy or chemoradiotherapy in the period
January 1998 — March 2003. Tumor extent was evaluated by CT and/or
MRI and/or TRUS examination and tumor biopsy
was performed during colonoscopy. The median follow up is 21
month. All patients received preoperative external beam radiation
to primary tumor, adjacent lymphnodes and presacral region.
Computed tomography localisation of target volume
was used for 3D radiotherapy treatment planning. Accelerated short
term regimen (25 Gy/5 fraction/1 week) was performed
in 14% of patients especially in year 1998—2000 and
normofractionated regimen (40—50 Gy/20—25 fractions/4—5 weeks)
was performed in 86% of patients. Chemoradiotherapy with 5-FU was
carried out in 22% of patients.
Radical resection underwent 85% of patients, inoperable tumor
persisted in 7% and distant metastases were detected
peroperatively in 8%. The 2-year overall survival (OS) was 84% and
5-year OS was 60% following radical resection. The
important prognostic factors affecting survival were
postradiotherapy determined pathological staging (p=0.005),
postradiotherapy tumor grade (p<0.001) and the presence of
angioinvasion and/or perineural spread (p=0.023). Prognostic
factors for disease-free survival were identical with those for
OS. Higher local recurrence rate was associated in
preradiotherapy tumor staged T4 (p=0.048) and in presence of
angioinvasion and/or perineural spread (0.049). Age, tumor
location, histological grade before radiotherapy and tumor
downstaging were not statistically significant for survival and/or
for local recurrence rate.
The best survival rates were obtained in patients with
postradiotherapy grade 1 tumors (5-years survival 100%), tumors
without angioinvasion and perineural spread (5-years survival 65%)
and in patients who obtained complete remission after
preoperative radiotherapy (5-years survival 86%).
Ako citovať:
ISO 690:
Prausová, J., Lohynská, R., Kubáčková, K., Linke, Z., Malinová, B., Kubala, E., Novotný Jr, J. 2006. Preoperative radiotherapy for locally advanced rectal cancer and prognostic factors influencing outcome. In NEOPLASMA, vol. 53, no.3, pp. 263-268. 0028-2685.
APA:
Prausová, J., Lohynská, R., Kubáčková, K., Linke, Z., Malinová, B., Kubala, E., Novotný Jr, J. (2006). Preoperative radiotherapy for locally advanced rectal cancer and prognostic factors influencing outcome. NEOPLASMA, 53(3), 263-268. 0028-2685.