In: NEOPLASMA, vol. 53, no. 3
E. Drozynska - E. Izycka-Swieszewska - M. Niedzwiecki - A. Balcerska - D. Perek - J. Wachowiak
Detaily:
Rok, strany: 2006, 247 - 252
O článku:
Seventy-four neuroblastoma patients were analyzed according to the
clinical data including age, stage, bone metastases,
primary tumor localization, tumor diameter, LDH, and serum
ferritin. Histological examination of tumor specimens comprised
calculation of proliferative index (PI) on slides stained with
anti Ki-67 antibody and assessment of microvascular
density (MVD) on anti-CD34 stained sections. Wide range of PI (1.5-79; median 37.8%) and MVD (41—385; median
172/mm2) values was observed. Significant relationship between
higher PI and tumor diameter more than 5 cm (40.3 vs
37.2%) was found. Lower PI was found more frequently in stroma-rich tumors. Significantly higher median MVD was
found in infant tumors and in smaller tumors <5 cm. Tendency to
inverse relationship between PI and MVD was observed.
The high values of both PI and MVD were found in some aggressive
tumors in patients >1-year old. We evaluated the new
parameter: proliferative-vascular index (PVI) as PVI=PIxMVD which
ranged from 213—18333. Among eleven patients >1
year old, with PVI >7000, seven (64%) had a poor outcome within
the mean period of 22 months. Our results suggest that the
simultaneous estimation of proliferative activity and vascularity
of neuroblastomas could be studied as a prognostic indicator.
Further investigations are needed to confirm this finding.
Ako citovať:
ISO 690:
Drozynska, E., Izycka-Swieszewska, E., Niedzwiecki, M., Balcerska, A., Perek, D., Wachowiak, J. 2006. A correlation of microvascular density and proliferative activity to clinical and histological characteristics in neuroblastoma. In NEOPLASMA, vol. 53, no.3, pp. 247-252. 0028-2685.
APA:
Drozynska, E., Izycka-Swieszewska, E., Niedzwiecki, M., Balcerska, A., Perek, D., Wachowiak, J. (2006). A correlation of microvascular density and proliferative activity to clinical and histological characteristics in neuroblastoma. NEOPLASMA, 53(3), 247-252. 0028-2685.