In: NEOPLASMA, vol. 53, no. 3
A. Mazurek - P. Kuc - S. Terlikowski - T. Laudanski
Detaily:
Rok, strany: 2006, 242 - 246
O článku:
The formation of new blood vessels in endometrial cancer tissue is
a main process, which leads to tumor progression, and
is connected with tumor expansion and invasiveness.
The aim of the study was evaluation of thymidine phosphorylase
protein (TP) expression in human endometrial cancer
cells by immunohistochemistry and comparison obtained data with
intensity of angiogenesis process and clinicopathological
factors as FIGO stage of disease and histopathologic grade.
Endometrial cancer specimens were obtained from
55 postmenopausal patients (aged 52 to 74 years) underwent total
abdominal hysterectomy with bilateral salpingo-oophorectomy. None of patients received preoperative pelvic
irradiation. Histopathological typing and grading of the
endometrial tumors (G-1, G-2, G-3) as well as myometrial invasion
(<1/2, >1/2) were assessed using standard criteria, on
hematoxylin-eosin sections. At the surgery, FIGO clinical stage of
disease was determined.
Thymidine phosphorylase overexpression was observed in 23 of 55
(41.8%) cases of endometrial cancer. Although we
found no statistically significant differences in TP expression
between histopathologic grades, particular FIGO stages
showed a significant trend of increase TP tumor overexpression.
Thymidine phosphorylase overexpression cases demonstrate
higher intensity of angiogenesis in comparison to negative samples
and results are statistically significant for t-test
(p<0.0001). The most intensive new blood vessel formation was
observed in G-2 of tumor differentiation grade (p=0.013 for
ANOVA test) Mean angiogenic points density (APD) values in cases
of G-1 histopathologic grade reached 135.7; values of
G-2 and G-3 grades reached 213.8 and 162.8, respectively. Mean
intensity of angiogenesis in the first FIGO stage of disease
reached 160.0 APD, in stage II 205.6 APD, and in the third 286.9,
respectively. Angiogenesis was more intensive in cases of
advanced tumors — analysis of variance (ANOVA) confirmed
statistically significant differences in APD values between
FIGO stage groups (p=0.0007).
In conclusion, thymidine phosphorylase expression correlates with
increased microvessel density in endometrial cancer.
The intensity of angiogenesis process increases according to FIGO
stage of disease, which is connected with progressing of
cancer disease. Thymidine phosphorylase can play an important role
in endometrial cancer progression and could offer additional
information about advance of disease.
Ako citovať:
ISO 690:
Mazurek, A., Kuc, P., Terlikowski, S., Laudanski, T. 2006. Evaluation of tumor angiogenesis and thymidine phosphorylase tissue expression in patients with endometrial cancer. In NEOPLASMA, vol. 53, no.3, pp. 242-246. 0028-2685.
APA:
Mazurek, A., Kuc, P., Terlikowski, S., Laudanski, T. (2006). Evaluation of tumor angiogenesis and thymidine phosphorylase tissue expression in patients with endometrial cancer. NEOPLASMA, 53(3), 242-246. 0028-2685.