Long-term clinical benefit of Peg-IFNα and NAs sequential anti-viral therapy on HBV related HCC

Rok, strany: 2021, 200 - 207

Analysis of the value of long-term antiviral therapy using sequential Peg-IFN therapy and nucleos(t)ide analogues (NAs) improves the prognosis of HBV-related HCC. HBV-related HCC patients were classified into sequential therapy with Peg-IFNα-2a and NAs, and NAs therapy alone. All patients were followed up for 5 years. The survival rate, HCC recurrence rate, Child-Pugh score, and side effects of drugs were evaluated. Firstly, the early and late cumulative survival rate was higher in patients receiving antiviral therapy compared with the control patients (p<0.05). Patients receiving sequential therapy with Peg-IFNα-2a and NAs showed a higher late cumulative survival rate and significantly reduced early and late recurrence rate, compared to those in the NA-alone group (p<0.05). Single NAs therapy only reduced the late recurrence rate in HCC-patients. Secondly, NAs therapy significantly increased the Child-Pugh score after five years of therapy (five-year therapy 7.03±1.50 vs. initial score 6.63±0.85; p<0.05), whereas the sequential therapy with Peg-IFNα-2a and NAs did not greatly alter the Child-Pugh score (6.88±1.26; p>0.05). Compared to the control patients, patients receiving antiviral therapy (NAs alone or sequential therapy with Peg-IFNα-2a and NAs) exhibited a significantly decreased Child-Pugh score (p<0.05). Compared to NAs alone, sequential therapy with Peg-IFNα-2a and NAs provided a more efficient strategy for improving both the five-year survival rate and the two-year or five-year recurrence rate in patients.

ISO 690:

Qi, W., Zhang, Q., Wang, X., Xu, Y., Zhao, P., Guo, H., Zhou, C., Sun, Y., Liu, L., Wang, J. 2021. Long-term clinical benefit of Peg-IFNα and NAs sequential anti-viral therapy on HBV related HCC. In NEOPLASMA, vol. 68, no.1, pp. 200-207. 0028-2685. DOI: https://doi.org/10.4149/neo_2020_200506N493

APA:

Qi, W., Zhang, Q., Wang, X., Xu, Y., Zhao, P., Guo, H., Zhou, C., Sun, Y., Liu, L., Wang, J. (2021). Long-term clinical benefit of Peg-IFNα and NAs sequential anti-viral therapy on HBV related HCC. NEOPLASMA, 68(1), 200-207. 0028-2685. DOI: https://doi.org/10.4149/neo_2020_200506N493

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