Association of triple positivity with prognostic parameters and overall survival in a population-based study of 6,122 HER2-positive breast cancer patients: analysis of real-world clinical practice based on a research database

Rok, strany: 2020, 1373 - 1383

Triple-positive breast cancer (TPBC), i.e. HER2-positive (HER2+) and hormone receptors-positive breast cancer, is a specific subgroup of breast cancers. TPBC biology is characterized by strong mutual interactions between signaling pathways stimulated by estrogens and HER2 amplification. The present study aims to carry out a population-based analysis of treatment outcomes in a cohort of hormone receptor (HR) positive and negative breast cancer patients who were treated with anti-HER2 therapy in the Czech Republic. The BREAST research database was used as the data source for this retrospective analysis. The database covers approximately 95% of breast cancer patients treated with targeted therapies in the Czech Republic. The analysis included 6,122 HER2-positive patients. The patients were divided into two groups, based on estrogen receptor (ER) or progesterone receptor (PR) positivity: hormone receptor negative (HR-) patients had both ER- and PR-negative tumors (n=2,518), unlike positive (HR+) patients (n=3,604). HR+ patients were more often diagnosed premenopausal at the time of diagnosis, presented more often at stage I or II and their tumors were less commonly poorly differentiated. The overall survival (OS) was significantly higher in subgroups of HR+ patients according to treatment setting. When evaluated by stages, significantly higher OS was observed in HR+ patients diagnosed at stages II, III, and IV and regardless of tumor grade.

ISO 690:

Kolarova, I., Vanasek, J., Dolezel, M., Stuk, J., Hlavka, A., Dusek, L., Melichar, B., Büchler, T., Ryska, A., Prausova, J., Petrakova, K., Tesarova, P., Petera, J., Vosmik, M., Horackova, K., Jarkovsky, J. 2020. Association of triple positivity with prognostic parameters and overall survival in a population-based study of 6,122 HER2-positive breast cancer patients: analysis of real-world clinical practice based on a research database. In NEOPLASMA, vol. 67, no.6, pp. 1373-1383. 0028-2685. DOI: https://doi.org/10.4149/neo_2020_191023N1080

APA:

Kolarova, I., Vanasek, J., Dolezel, M., Stuk, J., Hlavka, A., Dusek, L., Melichar, B., Büchler, T., Ryska, A., Prausova, J., Petrakova, K., Tesarova, P., Petera, J., Vosmik, M., Horackova, K., Jarkovsky, J. (2020). Association of triple positivity with prognostic parameters and overall survival in a population-based study of 6,122 HER2-positive breast cancer patients: analysis of real-world clinical practice based on a research database. NEOPLASMA, 67(6), 1373-1383. 0028-2685. DOI: https://doi.org/10.4149/neo_2020_191023N1080

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