miR-497 inhibits tumor growth and migration of osteosarcoma by targeting plexinA4 and CDK6

Rok, strany: 2020, 1122 - 1130

MicroRNAs are small non-coding RNAs that regulate gene expression at the post-transcriptional level which have been reported to be involved in the pathogenesis of various cancers. In the present study, we found that miR-497 was downregulated in osteosarcoma tissues. Gain and loss of function studies were carried out to investigate the effect of miR-497 on the growth of osteosarcoma cells. The results indicated that miR-497 inhibited the growth of osteosarcoma cells. Furthermore, bioinformatics analysis predicted plexinA4 and CDK6 as targets of miR-497, which was afterward confirmed by luciferase activity assay and rescue experiments. These findings suggested that miR-497, plexinA4 and CDK6 may serve as novel potential makers for osteosarcoma diagnostics and therapy.

ISO 690:

Tian, Z., Yan, M., Li, S., Cong, D., Wang, Y., Zhu, Q. 2020. miR-497 inhibits tumor growth and migration of osteosarcoma by targeting plexinA4 and CDK6. In NEOPLASMA, vol. 67, no.5, pp. 1122-1130. 0028-2685. DOI: https://doi.org/10.4149/neo_2020_200108N26

APA:

Tian, Z., Yan, M., Li, S., Cong, D., Wang, Y., Zhu, Q. (2020). miR-497 inhibits tumor growth and migration of osteosarcoma by targeting plexinA4 and CDK6. NEOPLASMA, 67(5), 1122-1130. 0028-2685. DOI: https://doi.org/10.4149/neo_2020_200108N26

Vydavateľ: AEPress, Ltd.