Circ-ITCH regulates triple-negative breast cancer progression through the Wnt/Î˛-catenin pathway

In: NEOPLASMA, vol. 66, no. 2

St Wang - Lb Liu - Xm Li - Yf Wang - Pj Xie - Q Li - R Wang - Q Wei - Yh Kang - R Meng - Xh Feng

Detaily:

Rok, strany: 2019, 232 - 239

O článku:

Recent studies indicate that circular RNA (circRNA) is involved in tumorigenesis, but its role in triple-negative breast cancer (TNBC) remains largely unknown. In this study, we characterized the role of circ-ITCH in TNBC and found that circ-ITCH was significantly down-regulated in TNBC tissues and cell lines and closely associated with poor prognosis. We therefore constructed the MDA-MB-231 and BT-549 TNBC cell lines stably expressing circ-ITCH by lentiviral vectors to determine its underlying mechanisms in TNBC progression. Most importantly, over-expression of circ-ITCH remarkably inhibited TNBC proliferation, invasion and metastasis both in vitro and in vivo. Mechanistically, we found that circ-ITCH acts as a sponge for miR-214 and miR-17 to increase expression of its ITCH linear isoform, thereby inactivating Wnt/Î˛-catenin signaling. Our combined results show for the first time that circ-ITCH is a tumor suppressor, a promising prognostic biomarker in TNBC and that its restoration could well be a successful strategy in TNBC.

Ako citovať:

ISO 690:

Wang, S., Liu, L., Li, X., Wang, Y., Xie, P., Li, Q., Wang, R., Wei, Q., Kang, Y., Meng, R., Feng, X. 2019. Circ-ITCH regulates triple-negative breast cancer progression through the Wnt/Î˛-catenin pathway. In NEOPLASMA, vol. 66, no.2, pp. 232-239. 0028-2685.

APA:

Wang, S., Liu, L., Li, X., Wang, Y., Xie, P., Li, Q., Wang, R., Wei, Q., Kang, Y., Meng, R., Feng, X. (2019). Circ-ITCH regulates triple-negative breast cancer progression through the Wnt/Î˛-catenin pathway. NEOPLASMA, 66(2), 232-239. 0028-2685.