In: General Physiology and Biophysics, vol. 37, no. 1
Ramzi Al-Horani - Mukhallad Mohammad
Rok, strany: 2018, 33 - 40
This study investigated the noradrenergic contribution during the cutaneous vasoconstrictor response to local cooling in the leg and forearm. On each limb, one site was perfused with Yoh/Prop to block the postsynaptic adrenoceptors and another with Lactated Ringer’s (control) using microdialysis. Blood flow was measured by Laser-Doppler flowmetry (LDF). Cutaneous vascular conductance (CVC) was calculated as LDF units divided by the mean arterial pressure. After baseline measures, skin was locally cooled to 24°C. Basal CVC was similar at all sites in the leg and forearm (all p > 0.1). During the first 10 min of local cooling, CVC was reduced in the leg (p < 0.005) and unchanged in the forearm control sites (p = 0.2). Yoh/Prop induced an increased CVC in the leg and forearm to a similar level (39.2 ± 11.5, and 41.3 ± 3.3%CVC, respectively; p < 0.35). Late during local cooling, the vasoconstriction was attenuated in the leg and forearm at Yoh/Prop (–38.2 ± 5.3 –37.1 ± 5.3%CVC, respectively; p = 0.5) compared to control sites (–69.1 ± 5.8 vs. –54.5 ± 6.4%CVC, respectively; p < 0.005). Noradrenergic contribution was greater in the leg than the forearm during the late vasoconstrictor response (p = 0.006). These data indicate that the leg skin can induce greater vasoconstriction than forearm during local cooling, possibly via higher noradrenergic sensitivity in the leg skin.
Al-Horani, R., Mohammad, M. 2018. The contribution of noradrenergic nerves to the vasoconstrictor response during local cooling of leg and forearm skin in humans. In General Physiology and Biophysics, vol. 37, no.1, pp. 33-40. 0231-5882.
Al-Horani, R., Mohammad, M. (2018). The contribution of noradrenergic nerves to the vasoconstrictor response during local cooling of leg and forearm skin in humans. General Physiology and Biophysics, 37(1), 33-40. 0231-5882.