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Témy doktorandského štúdia

Centrum biovied SAV

Názov témy
Potenciálna úloha kyseliny valproovej v potlačení zápalu
Program DŠ
Biochémia
Meno školiteľa/-ky
Mgr. Mária Balážová, PhD.
Kontakt:
Prijímajúca škola
Prírodovedecká fakulta UK
Stručná anotácia
The main objective of PhD thesis is to contribute to the knowledge about the potential use of valproic acid to induce the synthesis of phosphatidylglycerol in the pulmonary surfactant. To answer specific questions, we will use three models differing in their complexity – yeast (Saccharomyces cerevisiae), human tumor cell line (HAP1), and avian chorioallantoic membrane. We hypothesize that intracellularly increased phosphatidylglycerol level could suppress inflammatory responses in acute respiratory distress syndrome (ARDS) patients.