Information Page of SAS Organisation

Institute of Experimental Physics

International projects

Atmospheric electricity and secondary cosmic radiation
Atmosferická alektrina a sekundárne kozmické žiarenie
Program: Medziakademická dohoda (MAD)
Project leader: Mgr. Langer Ronald
Annotation:A continuation of recently started joint investigation into the relation between atmospheric electricity and dynamics, secondary cosmic radiation and space weather is proposed. A special focus will be paid to events that occur during thunderstorms, e.g., to enhanced count rates that were observed in particle detector SEVAN during periods of large electric fields, and search for a possible detection of particles during individual atmospheric discharges. The study will be based on measurements of electrostatic field, electromagnetic radiation from lightning, meteorological data, and energetic particles and gamma-rays on Lomnický peak. A further improvement and extension of measurement setup around Lomnický peak is anticipated. Atmospheric electric field will also be measured at several places in the Czech Republic. The main goal of the proposed project is a better understanding of mechanisms that couple atmospheric electricity and thunderstorms with energetic particles (radiation) and space weather. Both statistical approach and analysis of individual events will be performed.
Duration: 1.1.2018 - 31.12.2020

AMAZON - Dynamical study of formation/destruction of protein amyloid aggregatess targeted by magnetic zeolite nanocomposites
Dynamické štúdium amyloidnej agregácie proteínov pomocou magnetických zeolitových nanočastíc
Program: Bilaterálne - iné
Project leader: Doc. RNDr. Kopčanský Peter CSc.
Annotation:Abnormal protein aggregation and accumulation of formed fibrils are characteristic features for a range of, if not all, neurodegenerative disorders such as Alzheimer’s, Huntington’s, Parkinson’s, as well as non-neuropathic amyloidosis. Nanoparticles (NPs), attributed to its particularities in sizes, chemical composition and surface properties, have already been found effective in influencing amyloid fibrils. Our preliminary results acquired on amyloid fibrils incubated with in-laboratory synthesized Fe3O4 nanoparticles (MNPs) indicated reductive potential of MNPs on formation of amyloid fibrils, and also suggested facilitation of inhibiting preformation and eradication of amyloid fibrils may be plausible when the fibrils are exposed to external radiation in presence of MNPs. Also, with our previously reported photoluminescence properties of natural zeolite (CZ) which is a promising material for biomedicine and pharmaceutics due to its non-toxicity, thermal stability, expanded surface area, and exceptional ability to adsorb various atoms, organic molecules and nanoparticles into micro- and mesopores, we plan to apply the MNPs with CZ, developing multiphoton excitation microscopy (MPEM), and other appropriate instruments to establish the dynamical investigation of amyloid fibril formation and remodeling in real time. Prior to in vivo experiment, cytotoxicity in different type of cells and animal models such as zebrafish and mice will be evaluated.
Duration: 1.1.2018 - 31.12.2020

EMP - European Microkelvin Platform
Europská Mikrokelvinová Platforma
Program: Horizont 2020
Project leader: RNDr. Skyba Peter DrSc.
Project web page:www.emplatform.eu
Duration: 1.1.2019 - 31.12.2022

ALICE experiment at the CERN LHC: The study of strongly interacting matter under extreme conditions
Experiment ALICE na LHC v CERN: Štúdium silno interagujúcej hmoty v extrémnych podmienkach
Program: CERN/MŠ
Project leader: RNDr. Králik Ivan CSc.
Annotation:The project is aimed at the study of strongly interacting matter under extreme conditions of the p-p, p-Pb and Pb-Pb collisions at the energies of the LHC collider at CERN. The main program of the ALICE experimemt is the study of the quark-gluon plasma properties.
Project web page:http://osf.saske.sk/sk/?id=vyskum&sub=experimenty_ALICE
Duration: 1.1.2016 - 31.12.2020

ATLAS experiment on LHC in CERN: deep-inelastic events and new physics at TeV energies
Experiment ATLAS na LHC v CERN: hlboko-nepružné javy a nová fyzika pri TeV energiách
Program: CERN/MŠ
Project leader: Doc. RNDr. Bruncko Dušan CSc.
Project web page:http://www.saske.sk/UEF/OSF/ATLAS/atlas_1.html
Duration: 1.1.2016 - 31.12.2020

FMF - Flexible Magnetic Filaments: Properties and Applications
Flexibilné magnetické vlákna: Vlastnosti a aplikácie
Program: ERANET
Project leader: Doc. RNDr. Kopčanský Peter CSc.
Annotation:Different technologies for synthesis of flexible magnetic filaments are developed. These include linking magnetic micro-particles by DNA, attaching magnetic nanoparticles to polyelectrolyte bundles, extraction of magnetosomes from magnetotactic bacteria and other. Flexible magnetic filaments are interesting for applications as self-propelling microdevices(for targeted transport), micro-mixers (for microfluidics), different sensors(micro rheology). Numerical algorithms for predicting their behavior in magnetic fields of different configurations will be developed, including algorithms based on curve dynamics, lattice Boltzmann method, Brownian dynamics. Obtained numerical results will be compared with experimental results of measurement of flows fields around magnetic filaments, their buckling instabilities. As a result new technology will be developed for DLS measurements giving access to characteristics of translation and rotational motion of string like magnetic micro-objects.
Duration: 1.9.2018 - 31.8.2021

AMON-net - Follow-up of feasibility study to observe ionospheric disturbances by airglow monitoring network (AMON-net)
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Program: European Space Agency (ESA)
Project leader: RNDr. Mackovjak Šimon PhD.
Duration: 1.10.2018 - 30.9.2020

CHINMEDAMY - Discovery and Mechanism of Small Molecule Compounds from Traditional Chinese Medicine for treatment of Alzheimer 's Disease
Identifikácia a mechanizmus účinku malých molekúl využívaných v tradičnej čínskej medicíne na liečbu Alzheimerovej choroby
Program: Bilaterálne - iné
Project leader: doc. RNDr. Gažová Zuzana CSc.
Duration: 1.1.2018 - 31.12.2019

Cosmic rays as observed at two high mountain observatories: BEO Moussala and Lomnicky Stit
Kozmické žiarenie pozorované na dvoch vysokohorských observatóriách: Moussala a Lomnický štít
Program: Medziakademická dohoda (MAD)
Project leader: Mgr. Langer Ronald
Annotation:The main idea of the project is bilateral cooperation between two European high mountain stations (Lomnický štít, Slovakia and BEO Moussala, Bulgaria) in the field of solar phenomena (or extreme space whether events) as Forbush decrease (FD) and modulation effects on galactic cosmic rays (GCR), and their possible correlation with meteorological parameters. A Forbush decrease is a rapid decrease in the observed galactic cosmic ray intensity following a coronal mass ejection (CME). It occurs due to the magnetic field of the plasma solar wind sweeping some of the GCR away from Earth. The FD is usually observable by particle detectors on Earth within a few dаys аfter the CME, аnd the decrease takes place over the course of a few hours. Over the following severаl dаys, the sоlar cоsmic ray intensity rеturns tо nоrmal. Peer reviewed article (2) from 2009 found that low clouds contain less liquid water following Forbush decreases, and for the most influential events the liquid water in the oceanic atmosphere can diminish by as much as 7%. Further work (3, 4) found no connection between Forbush decreases and cloud properties until the connection was found in diurnal temperature range (5) and since confirmed in satellite data (6). 8NM64 neutron monitor measures continuously cosmic rays at Lomnický Štít (2634 m a.s.l., rigidity cut-off ~4GV) with high statistical accuracy (average count rate ~440 s-1) since December 1981 (7). The muon telescope at BEO Moussala (2925 m a.s.l., rigidity cut-off ~6.3 GV) is in operation since August 2006. The averaged yearly data show good anti-correlation with the averaged sun-spot number for the period August 2006 – June 2017 (to be published elsewhere), several FDs were also detected (8, 9 and 10). The CR data from the two stations will be analyzed for 11 years period and correlations between their variations and meteorological parameters will be investigated (11, 12). The effect of strong electric field around the time of the thunderstorms will be searched both at Moussala and at Lomnický štít with help of similar detector systems SEVAN being in operation at both stations as it was done recently for Lomnický štít (15). This may be especially importance because of different shape of surface at the stations (Lomnicky stit is rather sharp in altitude profile). The physics behind climate change is still a subject of discussion and in need of further analysis (13). The standard method of examining the effect of CR on CC is to search for a correlation of the time series of the two quantities: CC and CR (14). There are numbers of factors which need to be kept in mind, as follows: the presence of a correlation between CR and CC; the nature of CC; Global, spatial variability; Global temporal variability; Altitude differences. In what follows we examine the comprehensive meteorological data from the Lomnicky stit (LS) and BEO Moussala mountain observatories in comparison with Global data to answer the question: is there support for the hypothesis that CR contribute significantly to the local climate, by way of enhanced cloud cover? References 1. "Extreme Space Weather Events". National Geophysical Data Center. 2. "Cosmic ray decreases affect atmospheric aerosols and clouds". Geophys. Res. Lett. 17 June 2009 3."Atmospheric data over a solar cycle: no connection between galactic cosmic rays and new particle formation". 4."Sudden Cosmic Ray Decreases. No change of cloud cover" (PDF). 5."Forbush decreases – clouds relation in the neutron monitor era". Astrophys. Space Sci. Trans. 31 August 2011. 6. Svensmark, J; Enghoff, M. B.; Shaviv, N; Svensmark, H (September 2016). "The response of clouds and aerosols to cosmic ray decreases". J. Geophys. Res. Space Physics. 121 (9): 8152–8181. Bibcode:2016JGRA..121.8152S. doi:10.1002/2016JA022689. Retrieved June 5, 2017. 7. http://www.beo.inrne.bas.bg/BEOBAL/Conf_Pres/111.pdf 8. Angelov I., E. Malamova, J. Stamenov, The Forbush decrease after the GLE on 13 December 2006 detected by the muon telescope at BEO – Moussala, Advances in Space Research, 2008, v.43, n.4, p. 504-508, doi:10.1016/j.asr.2008.08.002 9. Tchorbadjieff Assen, Christo Angelov , Ivo Angelov , Todor Arsov , Ivo Kalapov, Nina Nikolova, Aneta Boyadjieva, Detection of coronal mass ejections (CMEs) in the period of march–may 2012 at Moussala peak, Comptes rendus de l’Academie bulgare des Sciences (C. R. Acad. Bulg. Sci.) vol 66, No 5, pp. 659-666, 2013 10. Assen Tchorbadjiev, Ivo Angelov, Christo Angelov, Nina Nikolova, Todor Arsov, Ivo Kalapov, Ani Boyadjieva, “Detection of Solar particle events in March 2012 at Moussala”, Bulgarian Astronomical Journal, 18(2), 2012, http://www.astro.bas.bg/AIJ/issues/n182/08-ATchorbad.pdf 11. Jordan Stamenov, Nina Nikolova, Luchezar Georgiev, “Correlation between cosmic rays intensity variation and nitrogen oxides in the atmosphere”, Issue Paradigma, pp. 134-140, 2010 12. Luchezar Georgiev, Nina Nikolova, Miloslav Katsarov, “Modeling and experimental research in Forbush-effect on the radiation background on the territory of the Republic of Bulgaria”, XI-th National Youth Science Conference, Federation of the Scientific-Engineering Unions in Bulgaria, ISSN: 1314-0698, 2013 (13) M. Kancírová, K. Kudela, A.D. Erlykin and A.W. Wolfendale, Relevance of long term time – series of atmospheric parameters at a mountain observatory to models for climate change, Journal of Atmospheric and Solar-Terrestrial Physics, http://dx.doi.org/10.1016/j.jastp.2016.08.002 (14) M. Kancírová, K. Kudela, Atmospheric Research 149 (2014) 166–173 (15) K Kudela, J. Chum, M. Kollarik, R. Langer, I. Strharsky and J. Base, Correlations between secondary cosmic ray rates and strong electric fields at Lomnicky stit, JGR Atmospheres, accepted September 26, doi: 10.1002/2016JD026439
Duration: 1.1.2018 - 31.12.2020

Nanocohybri - NANOSCALE COHERENT HYBRID DEVICES FOR SUPERCONDUCTING QUANTUM TECHNOLOGIES
NANOSCALE COHERENT HYBRID DEVICES FOR SUPERCONDUCTING QUANTUM TECHNOLOGIES
Program: COST
Project leader: Prof. RNDr. Samuely Peter DrSc.
Annotation:Superconducting technologies are prime candidates to ripen quantum effects into devices and applications. The accumulated knowledge in decades of work in understanding superconductivity allows scientists now to make experiments by design, controlling relevant parameters in devices. A new field is emerging whose final objective is to improve appliances taking advantage of quantum effects, be it for dissipationless transport of current, generation of high magnetic fields, sensors or quantum information. The field will impact crucial areas for societal development, including energy, transport, medicine or computation. Quantum behavior is controlled by using hybrids of superconductors with magnets, insulators, semiconductors or normal metals. Traditionally, the scientific and technical communities working in superconductivity are spread across projects from different calls, whose activities put Europe at the frontier of research. The present Action aims to address the pressing need for a common place to share knowledge and infrastructure and develop new cooperative projects.To this end, we have set-up a program including networking activities with an open, proactive and inclusive approach to other researchers and industry. We will develop the concept of a Virtual Institute to improve availability of infrastructure and knowledge, and focus on contributing to gender balance and the participation of young researchers. The proposal aims to avoid duplication of resources and skills in a subject traditionally dominated by small groups working independently. This will optimize European efforts in this area and uncover our full potential, thus maintaining and developing Europe’s leading position in superconducting quantum technologies.
Duration: 18.10.2017 - 17.10.2021

BIOSAP - Design of nanostructured bio-hybrid materials through self-assembly process
Nanoštrukturované bio-hybridné materiály generované samousporiadajúcimi procesmi
Program: Bilaterálne - iné
Project leader: RNDr. Tomašovičová Natália CSc.
Annotation:The aim of the present project proposal is to significantly contribute to the better understanding of the complex interaction between magnetic nanoparticles and host matrix based on the lyotropic liquid crystal. One of the key tasks of the project herein is to prepare bio-inorganic hybrids based on liquid crystals formed by lysozyme fibrils alongside doping of magnetic nanoparticles, to study the interaction between magnetic nanoparticles and lysozyme amyloid fibrils as well as their consequential structure. The project proposal primarily targets experimental research on a phenomenon observed in biological anisotropic colloidal suspensions, which have been extensively studied for its consequential relation with many human neurodegenerative disorders such as Alzheimers disease, Hungtingtons disease, and etc. Self-assembly of colloidal nanomaterials makes it possible to obtain structures with high level of ordering and permit construction of patterns to be used in optoelectronics, photonics and biosensing. However, the exact principle of mechanisms and the nature of the phenomenon are still unknown, and represent unexplored areas of research. Various experimental techniques already available at the collaborating institutions as detailed below will be employed to attain the main objective of the project as well as the related objectives itemized in the proposal.
Duration: 1.1.2018 - 31.12.2019

MAGBBRIS - New MAGnetic Biomaterials for Brain Repair and Imaging after Stroke
Nové magnetické biomateriály pre obnovu mozgu a zobrazovanie po mozgovej príhode
Program: ERANET
Project leader: Doc. RNDr. Kopčanský Peter CSc.
Annotation:By engineering novel magnetic nano-biomaterials we will achieve tissue repair in the context of an ischemic event. We will take advantage of nanotechnology to deliver therapeutic growth factors, secreted by progenitor cells, into the injured brain. According to the World Health Organization, 15 million persons suffer a stroke worldwide eachyear. However, the only available treatment is the acute thrombolytic therapy (pharmacological or mechanical) which is being administered to less than 10% of stroke patients due to strict selectioncriteria. In contrast, neuro-repair treatments could offer the opportunity to include most strokepatients by extending the therapeutic time window. MAGBBRIS will demonstrate that growth factors, secreted by endothelial progenitor cells, with proved potential to induce tissue repair, can be encapsulated in magnetic biomaterials and be successfully and safely transplanted into mouse brains to induce tissue repair. In the ischemic brain, the secretome will be retained by an external magnetic field in the vasculature, improving vascular remodelling and neurogenic tissue regeneration after stroke.
Duration: 1.3.2018 - 28.2.2021

MAGSAT - Novel soft magnetic cores tailored for use in space qualified magnetometers and satellite devices
Nové magneticky mäkké jadrá pre satelitné zariadenia a magnetometre pracujúce v kozmických podmienkach.
Program: JRP
Project leader: RNDr. Škorvánek Ivan CSc.
Duration: 1.9.2018 - 31.8.2021

NANOUPTAKE - Overcoming Barriers to Nanofluids Market Uptake ( NANOUPTAKE)
Prekonanie bariiér pre komerčné využitie nanokvapalín (NANOUPTAKE)
Program: COST
Project leader: RNDr. Timko Milan CSc.
Annotation:Nanofluids are defined as fluids that contain nanometre-sized particles with enhanced heat transfer properties. Nanofluids improve the efficiency of heat exchange and thermal energy storage. In addition, nanofluids fall within one of the Key Enabling Technologies (KET) supported by the European Commission. Although some nanofluid commercial applications currently exist, most of the current nanofluids are at Technological Readiness Levels (TRL) 1 to 3. Most of the nanofluids research in COST countries has been conducted by Research, Development and Innovation (R+D+i) centres through national funding. Additional coordinated research and development efforts are required to develop nanofluids up to higher TRL levels and to overcome commercial application barriers. If these barriers are overcome, nanofluids will be an important player in the Value Added Materials (VAM) for the energy sector.The objective of the NANOUPTAKE COST Action is to create a Europe-wide network of leading R+D+i institutions, and of key industries, to develop and foster the use of nanofluids as advanced heat transfer/thermal storage materials to increase the efficiency of heat exchange and storage systems.
Project web page:http://www.cost.eu/COST_Actions/ca/CA15119
Duration: 19.4.2016 - 18.4.2020

Research on preparation and magnetic properties of Co/CoO core-shell nanoparticles
Príprava a magnetické vlastnosti Co/CoO core-shell nanočastíc
Program: Medziakademická dohoda (MAD)
Project leader: RNDr. Škorvánek Ivan CSc.
Duration: 1.1.2018 - 31.12.2019

MMP REBCO - RE211 nanosize pining centers in REBCO bulks formed by modified precursor powder process
RE211 nanorozmerové piningové centrá v REBCO masívnych supravodičoch vytvorené MPP procesom
Program: Bilaterálne - iné
Project leader: Ing. Diko Pavel DrSc. akademik US
Annotation:REBa2Cu3O7 (in short REBCO or RE123, RE = Y or rare earth) bulk singlegrain superconductors (BSS) are a new unique class of superconductors with a perspective of being superconducting permanent magnets. One way to get closer to their practical applications is to reduce the price or to increase their properties by applying more efficient progressivetechnological procedures for their fabrication. The refinement of pining centers in the form of non-superconducting particles of the RE2BaCuO5 (RE211) phase is an important task in the production of REBCO BSS by top-seeded melt-growth (TSMG) process in the form of highparameter cryomagnets. The Laboratory of Materials Physics (LMF) at IEP SAS and the Department of Physics of JTU Shanghai have long been involved in the REBCO BSS research and have achieved a significant international position in this area. The latest results of collaborative groups show that replacing the conventional Y211 powder addition into the nominal composition by the mixture of Y2O3 and Ba2Cu3x powders can create nanoscale Y211 pining centers which will lead to a significant increase in the value of the maximum trappped magnetic field. Within the joint project, we want to extend this efficient process to SmBCO and GdBCO type BSS, which generally show higher values of the trapped magnetic field than YBCO BSS. In fulfilling this goal, we will seek optimal chemical composition and growth conditions of bulk crystals. Growth of BSS will take place mainly at the Departments of Physics, Shanghai Jiao Tong University during the stay of young scientists from LMF. The microstructural analysis and characterization of superconducting properties will be performed mainly at LMF. The planned mutual cooperation will significantly contribute to a faster progression of REBCO MMS research, in particular by complementing collaborative knowledge, joint use of unique experimental methodologies at individual labs as well as the scientific advancement of young scientists
Duration: 1.1.2018 - 31.12.2019

JUICE-PEP-ACM - Slovak contribution to ESA-JUICE mission: Development of Anti-Coincidence Module ACM for Particle Environment Package PEP
Slovenský príspevok k misii ESA-JUICE: Vývoj anti-koincidenčného modulu ACM pre časticový komplex PEP
Program: European Space Agency (ESA)
Project leader: Ing. Baláž Ján PhD.
Annotation:The ESA’s JUICE (JUpiter ICy moons Explorer) mission (http://sci.esa.int/juice) have to face to very hostile environment of Jovian radiation belts where the penetrating energetic electrons dominate. The Particle Environment Package (PEP) payload of this mission (http://sci.esa.int/juice/50073-science-payload ) is under development within a wide international collaboration led by Swedish Institute for Space Physics IRF in Kiruna. Due to limited available mass for efficient radiation shielding, the PEP payload will operate in rather unfavourable environment of penetrating energetic electrons that will affect the detection process inside the PEP/JDC (Jovian plasma Dynamics and Composition) sensor. To mitigate the unfavourable influence of the penetrating electron radiation to the plasma ions detection process, a concept of anti-coincidence module (ACM) has been identified within the PEP consortium. The project involves development of space-flight grade semiconductor solid state detector, the processing electronic board and a laboratory testing and calibration system RATEX-J (RAdiation Test EXperiment for JUICE).
Duration: 15.11.2018 - 30.10.2020

SPACE:LAB - place to attract, educate and involve young generation in space science and engineering
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Program: European Space Agency (ESA)
Project leader: RNDr. Mackovjak Šimon PhD.
Duration: 1.12.2018 - 30.11.2020

- - Study of the protein amyloid aggregation in vitro and in cerebrospinal fluid
Štúdium amyloidnej agregácie proteínov in vitro a v mozgomiešnom moku
Program: Medziústavná dohoda
Project leader: doc. RNDr. Gažová Zuzana CSc.
Annotation:Study of the amyloid aggregation of the protein in vitro and in the samples of the cerebrospinal fluid of the peoples with amyloid-related disease which obtain protein aggregation in vivo.Test of the assay for cerebrospinal fluid of the dementic and non-dementic peoples.
Duration: 13.7.2015 - 31.12.2020

SOOSA - Study of orientation ordering and self-assembly in biopolymer and liquid crystal
Štúdium usporiadania, orientácie a samozbaľovania v biopolyméroch a kvapalných kryštáloch
Program: Bilaterálne - iné
Project leader: RNDr., Ing. Šipošová Katarína PhD.
Annotation:Liquid crystals (LCs) are matter in a state which has properties between those of conventional liquids and those of solid crystals. Examples of liquid crystals can be found both in the natural world and in technological applications. LCs actually exhibit a plethora of unique and attractive properties that offer tremendous potential for fundamental science as well as innovative applications depending on ordering properties of anisotropic molecules at interfaces in systems. In particular, new bio-nanocomposites consisting of protein amyloid fibrils (that can be consider as long and rigid objects similarly copolymers due to their stability and rigidity) and magnetic nanoparticles provide achievement of high special order and alignment. Within the project, we propose to focus on the effects of backbone-alignment on the ordering and self-assembly in these systems.
Duration: 1.1.2018 - 31.12.2019

Theoretical and experimental studies of orientational, magneto-optical and dielectric properties of composite liquid crystals filled with magnetic particles.
Teoretické a experimentálne štúdium orientačných, magneto-optických a dielektrických vlastností kompozitov kvapalných kryštálov dopovaných magneticckými časticami.
Program: Medziakademická dohoda (MAD)
Project leader: RNDr. Tomašovičová Natália CSc.
Annotation:At the last decades, one of the important areas of modern soft matter physics is theoretical and experimental study of liquid crystals (LC) which are very attractive for use in various commercial exploitations. The great interest of researchers to this area of science is explained, first of all, by fast development of electronic technique and communication equipments which require reliable, convenient and compact devices for processing and displaying information – indicators, displays, screens, etc. The successful use of LC materials in such devices considerably expanded a circle of technical applications of liquid crystals: now they are applied also in modern industrial machineries, in different transport vehicles and systems, medicine, household appliances, etc. Additionally, the search for new materials with exotic properties and for new technologies continues, in order to comply with the needs of these, and other novel applications.
Duration: 1.1.2017 - 31.12.2019

RBS - Research on bulk superconductors
Výskum masívnych supravodičov
Program: Iné
Project leader: Ing. Diko Pavel DrSc. akademik US
Annotation:The agreement on cooperation between IEP SAS and CAN Superconductorsis focused on research od REBCO bulk supercondyctors for practical applications.
Duration: 1.5.2018 - 30.4.2023


National projects

Analysis of EUSO-SPB, Mini-EUSO and ground UV detectors experiments measurement
Analýza meraní z experimentov EUSO-SPB, Mini-EUSO a siete pozemných UV detektorov
Program: VEGA
Project leader: RNDr. Bobík Pavol PhD
Annotation:JEM-EUSO experiment is a project to determine the origin of ultra high energy particles. Its two most important precursor experiments are EUSO-SPB and Mini-EUSO ones. Both of them will yield new data during the years 2017 and 2018. This project is aimed to data processing from both experiments and from the grid of terrestrial detectors of UV radiation. EUSO-SPB is a flight of NASA SPB balloon with EUSO detector which will start in April 2017 from New Zealand fot at least 50 days long flight. Mini-EUSO detector is miniature version of JEM-EUSO detector, which will monitor UV background onboard International Space Station. Mini-EUSO flight and the beginning of its at least half year measurements will start at the end of the year 2017. Department of space physics IEP is building at the same time a grid of terrestrial detectors of UV background, which will start continuos measurements on minimallly 4 positions during the year 2017. Their operation is planned over the full duration of this project.
Duration: 1.1.2017 - 31.12.2019

ANGSTROM - Atomic structure and exceptional properties of intermetallics, amorphous, nanocrystalline and complex metallic alloys
Atomárna štruktúra a unikátne vlastnosti intermetalík, amorfných, nanokryštalických a komplexných kovových zliatin
Program: APVV
Project leader: RNDr. Škorvánek Ivan CSc.
Duration: 1.7.2016 - 31.12.2019

Deformation of metastable amorphous and crystalline materials
Deformácia metastabilných amorfných a kryštalických materiálov
Program: VEGA
Project leader: RNDr. Csach Kornel CSc.
Duration: 1.1.2018 - 31.12.2021

MACOMA - Design of the structure and the functional properties of soft magnetic 3-d transitions metals based composites
Dizajn štruktúry a funkčných vlastností magneticky mäkkých kompozitných materiálov na báze 3-d prechodných kovov
Program: APVV
Project leader: RNDr. Baťková Marianna PhD.
Annotation:The project focuses on structure and functional properties design of 3-d transition metals based soft magnetic composite materials, in which will be carried out the experimental research of functional properties of advanced materials with heterogeneous structure consisting of isolated ferromagnetic particles. Magnetic micro- and nanocomposite systems will be prepared using advanced powder metallurgy method and current chemical processes. The research will be focused on explanation of the interface influence on the electric, magnetic and mechanical properties investigated magnetic composite materials. Expected results extend the potential for application of advanced soft magnetic materials suitable for use in a medium frequencies, where ferrites are currently used.
Duration: 1.7.2016 - 31.12.2019

EXSES - Exotic quantum states of low-dimensional spin and electron systems
Exotické kvantové stavy nízkorozmerných spinových a elektrónových systémov
Program: APVV
Project leader: RNDr. Čenčariková Hana PhD
Annotation:The project is devoted to theoretical study of low-dimensional quantum spin and electron systems, which will be examined by the combination of advanced analytical and numerical methods including among other matters exact mapping transformations, transfer-matrix method, strong-coupling approach, classical and quantum Monte Carlo simulations, exact diagonalization and density-matrix renormalization group method. The obtained theoretical outcomes will contribute to a deeper understanding of exotic quantum states of spin and electron systems such as being for instance different kinds of quantum spin liquids as well as quantum states with a subtle long-range order of topological character or with a character of valence-bond solid. The project will significantly contribute to a clarification of unconventional magnetic behavior of selected low-dimensional magnetic materials and thus, it will have significant impact on a current state-of-the-art in the field of condensed matter physics and material science. On the other hand, a detailed investigation of quantum entanglement will establish borders of applicability of the studied spin and electron systems for the sake of quantum computation and quantum information processing. Another important outcome of the project is to clarify nontrivial symmetries in tensor states of the strongly correlated spin and electron systems affected by either position dependent interactions or changes in lattice geometries, which induce phase transitions of many types.
Duration: 1.7.2017 - 30.6.2021

FRUSTKOM - Frustrated metallic magnetic systems
Frustrované kovové magnetické systémy
Program: APVV
Project leader: Doc. RNDr. Gabáni Slavomír PhD.
Annotation:The up to now experimental and theoretical studies of frustrated magnetic systems (FMS) has been concentrated mainly on dielectric systems. Such systems can be found in 2D and 3D lattices based on equilateral triangles, and in dielectrics the interaction between their spins can be relatively well defined and described. In metallic FMS (M-FMS), which have been much less studied, an important role plays the long-range indirect exchange interaction between the spins mediated by conduction electrons (the RKKY interaction). To the small number of up to now studied M-FMS belong also some rare earth metallic borides having a fcc (e.g.HoB12, ErB12) or Shastry-Sutherland (e.g.TmB4, HoB4, ErB4) structure. This project aims are to investigate experimentally the impact of high pressure (hydrostatic and uniaxial), the influence of alloying and the anisotropy on the magnetic, transport and thermal properties of M - FMS, which has not been studied yet. A pioneering work will be above all the direct observation of magnetic structures of individual phase diagram regions of these M-FMS by spin-polarized scanning tunnelling microscopy. Investigated will be also the dynamics of magnetic structures (the influence of the rate of change of the magnetic field on these structures) and the study of magnetic excitations (by neutron diffraction methods) in selected tetraborides and dodecaborides. The challenging experimental studies, for which both high quality samples and suitable methods are already available, will be supported by the theoretical interpretation of received results, and by the theoretical elaboration.
Project web page:http://extremeconditions.saske.sk/projects/
Duration: 1.8.2018 - 30.6.2022

GONanoplatform - Graphene-based nanoplatform for detection of cancer
Grafénová nanoplatforma na detekciu rakoviny
Program: APVV
Project leader: Ing. Koneracká Martina CSc.
Annotation:This project proposal reflects current technological progress and new opportunities in biomedical applications of graphene-based sensors. Our main goals include the design and development of a graphene oxide multifunctional nanoplatform (GO-MFN) for the detection of tumor cells. In the first step, the development of graphene oxide nanoflakes of appropriate size functionalized by monoclonal antibody is planned. For sensing the tumor cells, GO-MFN of 100 nm size able to interact with a single cell will be prepared. Magnetic nanoparticles added to GO-MFN will enable the inspection of deep tissues by nuclear magnetic resonance. The degree of oxidation of GO, type of the functional groups, optimal functionalization with covalently bound monoclonal antibodies and magnetic nanoparticles, are the most important technological steps. The analysis of the basic interactions related to tumor sensing will be conducted in vitro on 2D and 3D cell models up to the proof-of-principle stage that will be directly applicable to laboratory and preclinical testing. The GO-MFN interaction with the cell membrane and with the cell interior will be analysed with subcellular resolution. Such an approach will bring original knowledge and a detailed understanding of the tumor sensing process that is important for the optimization of the sensor sensitivity. Detection of biomolecules bound to GO-MFN will be addressed in real time by several techniques. The project is based on a complex multidisciplinary approach, ranging from physics and chemistry up to biomedicine and combining excellent science and the most sophisticated nano and bio-engineering. The involved partners possess key skills, infrastructure, antibodies and tumor models, and are highly motivated to reach the project goals.
Duration: 1.7.2015 - 30.6.2019

Interaction of magnetic fluids with electromagnetic field
Interakcia magnetických kvapalín s elektromagnetickým poľom
Program: VEGA
Project leader: RNDr. Timko Milan CSc.
Annotation:The proposed project will be devoted to the study magnetic principle of heating mechanism – hyperthermia in magnetic nanoparticles systems in dependence on preparation process, size and size distribution and magnetic properties. Besides usually used biocompatible spherical anoparticles as a subjects of this proposal will be special prepared magnetosome and magnetoferritin containing spherical magnetite nanoparticles. The obtained experiences for achievement high specific heat power will enable the application magnetic nanoparticles at cancer treatment in biomedicine. We aim to investigate the shielding (absorption and reflection) effects of transformer oil based magnetic fluid. Besides the unique cooling and isolating properties, these magnetic fluids can be reliable shielding medium in electromagnetic devices as well. The research on radiation stability of MFs will address electromagnetic fields and another type radiation.
Duration: 1.1.2016 - 31.12.2019

Interactions of relativistic nuclei, eta-meson nuclei and spin physics
Interakcie relativistických jadier; eta-mezónové jadrá a spinová fyzika
Program: VEGA
Project leader: Mgr. Mušinský Ján PhD.
Duration: 1.1.2018 - 31.12.2020

Classical to quantum crossover in mechanical resonators
Klasicko-kvantový prechod v mechanických rezonátoroch
Program: VEGA
Project leader: RNDr. Človečko Marcel PhD.
Annotation:The material variability and dimensional diversity of mechanical resonators allows us to deliberately change their physical and geometric properties. Thus by reducing their mass / energy content (i.e. by decreasing their size)while simultaneously cooling them to temperatures close to absolute zero, it is possible to use them as a tool to study the crossover between classical and quantum dynamics. The ambition of our project is (i) the study of nonlinear processes in macroscopic resonators based on piezomaterials, (ii) the study of the transition between classical and quantum dynamics by using our custom made mechanical micro and nanoresonators and (iii) to deepen the understanding of fundamental processes of the energy exchange between these resonators and the thermal reservoir leading to the decoherence.
Duration: 1.1.2018 - 31.12.2021

Complementary study of superconductivity of selected materials
Komplementárne štúdium supravodivosti vybraných materiálov
Program: VEGA
Project leader: RNDr. Kačmarčík Jozef PhD
Annotation:Since the discovery of the two-gap superconductivity in MgB2 almost 15 years ago, a continuous search for other examples of this special feature is maintained. Another interesting issue of these days in condensed matter physics is investigation of materials with competing orders, where for example superconductivity coexists or compete with magnetic ordering or charge density waves. Within the project we will focus on study of several representatives of these groups – we will confirm or disconfirm presence of two energy gaps in LaRu4As12 and Bi2Pd, we will explore competing orders in CuxTiSe2 and CeCoIn5 and we will address spatially constrained superconductivity in granular doped diamond. Clarification of their superconducting mechanism could shed some light on other superconducting materials. We will also work on development of new experimental methods – implementation of a resistive calorimeter and mastering and further enhancement of local magnetometry using Scanning Hall-probe microscope.
Duration: 1.1.2016 - 31.12.2019

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Kozmické energetické častice zo slnečných erupcií – mnohobodové pozorovanie od Slnka až po Lomnický Štít
Program: VEGA
Project leader: RNDr. Bučík Radoslav PhD
Duration: 1.1.2018 - 31.12.2021

QuTeMaD - Quantum Technologies, Materials and Devices
Kvantové technológie. materiály a zariadenia
Program: APVV
Project leader: Prof. RNDr. Samuely Peter DrSc.
Annotation:Within the project we will focus on development of particular devices based on superconductors or superconducting circuits working up to quantum limit. One of the main goal of the project is a practical amplifier which bring real and considerable improvement over the high electron mobility transistor (HEMT) amplifiers. Our aim is to go beyond the state-of-the-art and fabricate subquantum-limited parametric amplifier, a key element for quantum information processing with microwaves. In order to achieve this aim we will investigate novel quantum materials which can improve properties of quantum devices. Therefore, the fundamental research of new topological materials including topological insulators and superconductors will thus be a logical and integral part of our project.
Duration: 1.7.2017 - 31.12.2020

Magnetization and relaxation processes in magnetic particles and composites.
Magnetizačné a relaxačné procesy v magnetických časticiach a kompozitoch.
Program: VEGA
Project leader: RNDr. Kováč Jozef CSc.
Annotation:The project is oriented on experimental investigation of the structure and magnetic properties of magnetic particles with the size of several nanometers to several hundred micrometers. The particles (with amorphous, nanocrystalline, or polycrystalline structure) are based on ferromagnetic metals and alloys, and are covered with an inorganic or organic layer, and after technological treatments become precursors for the preparation of composites. The research is focused on investigation the magnetization and relaxation processes in ferromagnetic particles under different physical conditions as ferromagnetic phase content, temperature, amplitude and frequency of the magnetic field. Expected results will help to expand the application potential of this class of advanced materials for a variety of medical and technological applications.
Duration: 1.1.2016 - 31.12.2019

Magnetoelectric and magnetocaloric effect in exactly solvable lattice-statistical models
Magnetoelektrický a magnetokalorický jav v exaktne riešiteľných mriežkovo-štatistických modeloch
Program: VEGA
Project leader: RNDr. Čenčariková Hana PhD
Annotation:Magnetoelectric and magnetocaloric effects will be examined in detail with the help of exactly solvable lattice-statistical models including Ising spin systems, Ising-Heisenberg spin systems and coupled spin-electron systems, which consist of localized Ising spins and delocalized electrons. The primary goal of the project is to explore an influence of external electric field on basic magnetic properties and an influence of external magnetic field on basic thermodynamic properties of the studied lattice-statistical models. A response of magnetic system on a change of external electric and magnetic fields will be investigated mainly in a vicinity of phase transitions (including quantum ones), where particularly interesting behaviour can be expected. The rigorous theoretical results will contribute to a deeper understanding of both studied cooperative phenomena, what enables to propose a subsequent optimalization of technologically important properties of multifunctional materials and magnetic refrigerants.
Duration: 1.1.2016 - 31.12.2019

Macroscopic anisotropic composites based on liquid crystals and magnetic nanoparticles
Makroskopicky anizotrópne kompozity na báze kvapalnych kryštálov a magnetických nanočastíc
Program: VEGA
Project leader: RNDr. Tomašovičová Natália CSc.
Annotation:The proposal targets basic research on composite materials consisting of liquid crystals and various magnetic nanoparticles. Combination of the anisotropic properties of liquid crystals with the magnetic properties of the nanoparticles results in composites with unique magnetic and optical properties that the component materials themselves do not possess. The proposed studies concentrate on the increase of the sensitivity of our composite soft matter materials (liquid state) to magnetic fields and prepare new materials having unique dielectric, magnetic and optical properties. The main goal of the proposal is to influence the sensitivity of these anisotropic systems to external magnetic field by adding suitable magnetic nanoparticles and by this way make a step forward towards potential applications in various magneto-optical or dielectric devices as for example sensors of low magnetic fields or light shutter.
Duration: 1.1.2017 - 31.12.2020

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Mezoškálové javy a štruktúry v mäkkých látkach polymérneho a nepolymérneho charakteru,
Program: VEGA
Project leader: RNDr. Sedlák Marián DrSc.
Duration: 1.1.2017 - 31.12.2019

Supramolecular complexes of proteins – conformational transitions, stability and aggregation
Nadmolekulárne komplexy proteínov - konformačné prechody, stabilita a agregácia
Program: VEGA
Project leader: RNDr. Fedunová Diana PhD.
Annotation:Protein aggregation and self-assembly into supramolecular complexes occurs in various biological processes. Fibrillar aggregates - amyloids are hallmark of various diseases. Amyloid fibrils are part of physiological processes in cells and are also tested as novel biomaterials. The project is focused on study of the effect of two classes of cosolvents on amyloid aggregation of structurally different polypeptides – globular lysozyme and intrinsically disordered Aß peptide. The aim of the project is to find the relation between cosolvent properties and their effect on conformation, stability and kinetics of amyloid aggregation and morphology of obtained fibrils. Elucidation of these relations is important for the understanding of the mechanism of amyloid aggregation and can help to design new therapeutics against amyloid-related diseases, for identification of pathological structural motifs of fibrils as well as in biotechnological application of fibrils as novel materials.
Duration: 1.1.2018 - 31.12.2021

MVISION - Nanoparticles in anisotropic systems
Nanočastice v anizotrópnych systémoch
Program: APVV
Project leader: Doc. RNDr. Kopčanský Peter CSc.
Annotation:The proposal is devoted to study complex anisotropic systems based on thermotropic as well as lyotropic (biological) liquid crystals. Liquid crystals represents the uniq state of matter, which is liquid but posses the anisotropic properties. The structuralization phenomena in such systems play key role in fundamental as well as in applied research. The main aim is to s influence the sensitivity of these anisotropic systems to external magnetic field, what will be done by adding suitable magnetic nanoparticles and open the way for their applications in magneto-optical devices.
Duration: 1.7.2016 - 30.6.2020

NANOSEG - Nanosegregation in soft matter of polymeric and nonpolymeric nature
Nanosegregácia v mäkkých látkach polymérneho a nepolymérneho charakteru
Program: APVV
Project leader: RNDr. Sedlák Marián DrSc.
Duration: 1.7.2017 - 31.12.2020

MICROMANIP - Image analysis of microscopic particles in the automation of optical manipulation techniques applicable in mikro/nanorobotics.
Obrazová analýza mikroskopických častíc pri automatizácii optických manipulačných techník aplikovateľných v mikro/nanorobotike.
Program: APVV
Project leader: Doc. Ing. Tomori Zoltán CSc.
Annotation:Mikromanipulation based on the laser optical traps represents a progressive method of basic research in the physical, chemical and biomedical sciences. An analogy between the optical manipulation and the robotics evokes exploitation of the artificial intelligence algorithms (computer vision, machine learning, planning of trajectories, etc.). According to some authors, the use of these methods in combination with physical models has led to the significant increase of the effectiveness compared to the classic optimization (up to 1000 times in SVM classifier trained in advance using the Lorenz-Mie scattering light model). The aim of the project is to use a similar philosophy for the experimental tasks solved in our laboratory - cells sorting and fusing, their physical properties measurement and etc. Using the apparatus for 2-photon polymerization we plan to manufacture microrobotic instruments controlled by the optical tweezers traps, e.g. a mikrorobotic arm (gripper). As continuity with our previous project, we would improve the interactive control of optical tweezers via NUI interface (using the position of the fingers and gaze, voice, gestures). This interface should be functional not only locally, but also remotely over a network connection.
Duration: 1.7.2016 - 31.12.2019

Functional and Structural Insights into the Phospholipid-Protein Interaction during Oxidative Stress
Oxidačný stres a fosfolipidovo-proteínové interakcie: funkčné a štrukturálne dôsledky
Program: VEGA
Project leader: MUDr. Musatov Andrey DrSc.
Annotation:Mitochondria play a critical role in cells metabolism and mitochondrial dysfunction has long been implicated in age-related neurodegenerative diseases. One currently accepted theory is that damage to mitochondria, the main source of reactive oxygen species (ROS), initiates these diseases. In fact, when ROS levels overpower the cell’s defenses (oxidative stress), proteins, nucleic acids and/or lipids are irreversibly damaged. Particularly important is that oxidative stress disrupts or modifies the protein-lipid interactions what is one of the essential features of normal cell operation. Such disruptions could be a decisive factor leading to ROS-induced diseases. To test this hypothesis and clearly elucidate the links between mitochondrial oxidative stress and cells dysfunction we propose to investigate both, (i) the role of phospholipid modification in ROS-induced damage to mitochondrial electron transport Complex IV, and (ii) the role of phospholipids and oxidatively modified phospholipids in amyloidogenesis.
Duration: 1.1.2017 - 31.12.2020

PSI - Superconductor - insulator transition
Prechod supravodič - izolant
Program: APVV
Project leader: Mgr. Szabó Pavol CSc.
Annotation:The project aims at understanding the problem of how superconductor transforms to insulator at increased disorder. The questions of what is the force driving the superconducting transition temperature to lower values in ultrathin superconducting films and what is the mechanism of the quantum phase transition between superconducting and insulating states will be addressed experimentally as well as theoretically. The superconducting films of various content with thicknesses down to few atomic layers as well as the nanostructures and resonators on their basis will be prepared. Transport, microwave and optical properties of these objects will be investigated. By means of the subkelvin scanning tunnelling microscope the spectral maps of the quasiparticle density of states at ultralow temperatures and in high magnetic fields will be measured. We will explore possibilities to prepare sensitive photon detectors and amplifiers based on ultrathin disordered superconducting films for the spectroscopy in physics, chemistry and biology. Dynamics of the surface states in another macroscopic quantum object, the superfluid 3He which is the topological insulator at ultra low temperatures, will be investigated experimentally as well as theoretically. The objective is to elucidate the dynamics of surface bound excitations in superfluid 3He by means of mechanical resonators and resolve if the excitations can be identified with the long searched Majorana fermions. By experiment the recent question if samarium hexaboride is a topological insulator will be addressed.
Duration: 1.7.2015 - 30.6.2019

Self-assembly of poly/peptides into amyloid aggregates – mechanism, inhibition and cytotoxicity
Samousporiadanie poly/peptidov do amyloidných agregátov - mechanizmus, inhibícia a cytotoxicita
Program: VEGA
Project leader: doc. RNDr. Gažová Zuzana CSc.
Annotation:Amyloid supramolecular complexes formed by poly/peptides are the most prevalent naturally occurring self-assembling systems. Formation of such complexes affects function of poly/peptides and is associated with more than 30 serious amyloid-related diseases such as Alzhemer’s disease or diabetes mellitus. The exact mechanism of amyloid self-assembly of poly/peptides is not known yet and no effective treatment of amyloidosis is established. The goal of the project is to study the mechanism of the amyloid aggregation of poly/petides with different native structures and identification of inhibitors of poly/peptide self-assembly since the inhibition of amyloid formation is one of the possible therapeutic approaches against amyloid-related diseases. We will focus on the determination of the correlation between the morphology of amyloid aggregates and their cytotoxicity as well as on the relationship between structure of the effective inhibitors and their anti-amyloid activity.
Duration: 1.1.2017 - 31.12.2020

Skúmanie vlastností jadrovej matérie v produkcii ťažkých kvarkov na jadrových terčíkoch
Skúmanie vlastností jadrovej matérie v produkcii ťažkých kvarkov na jadrových terčíkoch
Program: VEGA
Project leader: RNDr. Nemčík Ján CSc.
Annotation:The main goal of the present project is theoretical study of nuclear effects in various processes on nuclear targets at large energies. The main emphasize is devoted to production of heavy quarks representing an alternative probe for investigation of manifestations and properties of nuclear matter created in heavy-ion collisions.
Duration: 1.1.2018 - 31.12.2021

Supramolecular complexes of biomacromolecules
Supramolekulárne komplexy biomakromolekúl
Program: VEGA
Project leader: RNDr. Valušová Eva PhD.
Annotation:Cells have numerous examples of nonmembrane-bound compartments containing many biomacromolecules. However, their physicochemical properties play an important role in a number of biological processes, but their complex biochemistry still remain poorly understood. These granules exhibit liquid-like behavior. Two or more biomacromolecules that interact with each other form liquid droplets in which their concentration is higher than in the surrounding aqueous medium. Furthermore, high concentrations of solutes, ions and also some low - molecular weight molecules contribute to mesoscale organization in certain biological systems. The project is devoted to address processes allowing preparing and characterization physicochemical properties of supramolecular complex models of nonmembrane-bound compartments and will also concentrate on mechanisms that occur during these processes.
Duration: 1.1.2016 - 31.12.2019

Systematic study of influence of local and nonlcal interactions on coexistence of quantum phases with different order parameters
Systematické štúdium vplyvu lokálnych a nelokálnych interakcií na koexistenciu kvantových fáz s rôznymi parametrami usporiadania
Program: VEGA
Project leader: RNDr. Farkašovský Pavol DrSc.
Annotation:The proposed project is focused on the complex study of influence of local and non-local interactions, of the Coulomb and spin nature, on the ground state properties of the generalized two-band Hubbard model. The results obtained will be used for a description of anomalous cooperative phenomena in real materials with strongly correlated electrons. The study will include a wide class of cooperative phenomena such as valence and metal-insulator transitions, charge and spin ordering, itinerant ferromagnetism, electronic ferroelectricity, supercoductivity, excitonic matter and will concern a wide class of materials such as nickelates, cobaltates, rare-earth hexaborides and chalcogenides,multiferroics, etc. The emphasis will be put on the study of influence of combined effects of two or more interactions with a goal to describe coexistence of two or more quantum phases with different order parameters (ferromagnetic-ferroelectric state, charge/spin ordering-superconductivity, etc.).
Duration: 1.1.2018 - 31.12.2021

Study of universal properties of diffusion proceses in turbulent environments
Štúdium univerzálnych vlastností difúznych procesov v turbulentných prostrediach
Program: VEGA
Project leader: RNDr. Jurčišin Marián PhD.
Annotation:One of the basic attributes of macroscopic physical, chemical, biological, and also social-economical and environmental systems is their stochasticity. This fact is the main reason for present intensive scientific interest about various stochastic systems. Advection of various admixtures in random environments, turbulence and magnetohydrodynamic turbulence, or crossing of cosmic particles through interstellar space, are typical examples. The importance of intensive Investigation of these problems is dictated by need for fundamental understanding of the physical nature of phenomena which are involved in them, as well as from the point of view of their potential future applications in technical praxis. The aim of the project is the study of the anomalous scaling of structure and correlation functions of fluctuating fields in turbulent systems without and with symmetry breaking, as well as the study and the calculation of universal characteristics of such turbulent systems.
Duration: 1.1.2017 - 31.12.2020

NANOSIMKA - Effects of nanoencapsulated simvastatin on cardiovascular system in experimental metabolic syndrome
Účinok nanoenkapsulovaného simvastatínu na kardiovaskulárny systém pri experimentálnom metabolickom syndróme
Program: APVV
Project leader: Ing. Závišová Vlasta PhD.
Annotation:High level of cholesterol in the blood increases the risk of heart and vascular diseases. Simvastatin reduces cholesterol production in the liver thus reduces the blood cholesterol level. Long-term use of statins has been associated with the occurrence of side effects, which in addition increase with increasing their dose. In particular, the statin side effect include mainly inhibition of the endogenous synthesis of CoQ10 - basic cofactor for ATP synthesis and paradoxically activation of PCSK9 - an important enzyme for the synthesis of LDLcholesterol. The project aims to increase the bioavailability of simvastatin in the liver, thus reducing the daily dose and consequently to prevent the reduction of CoQ10 levels as well as to block the activation of PCSK9. In order to achieve this this aim, nano-encapsulated simvastatin together with nano-encapsulated CoQ10 or PCSK9 inhibitor, or in the polymer with antioxidant properties will be prepared, tested and applied. This ensures the targeted transport of simvastatin to the liver simultaneously with CoQ10, or inhibitor of PCSK9, or simultaneous increase in antioxidant capacity. In the case of successful results the proposed project may uncover new possibility of using nanocarriers for the treatment of metabolic and cardiovascular diseases.
Duration: 1.7.2015 - 30.6.2019

The role of surface states in samarium hexaboride and other valence-fluctuating systems exhibiting metal-insulator transition
Úloha povrchových stavov v hexaboride samária a iných zmiešanovalenčných systémoch vykazujúcich prechod kov-izolátor
Program: VEGA
Project leader: RNDr. Baťková Marianna PhD.
Annotation:Samarium hexaboride (SmB6) represents an important model system exhibiting metal-insulator transition. A mysterious property of this valence fluctuating semiconductor is that at lowest temperatures it does not reveal divergency of electrical resistivity, but behaves as a metal. SmB6 is nowadays intensively studied also as a possible topological insulator, while metallic topologically protected surface is considered to be a reason of absence of insulating ground state. However, the latest results provide evidence about trivial surface states in SmB6. The project aims to evaluate the role of surface states in electrical conduction of SmB6 by investigating SmB6 thin films, to evaluate relevance of the scenario of topological insulator and other alternative approaches to explain electrical conductivity in SmB6, thus to contribute to understanding the nature of electronic transport in SmB6 and similar systems.
Duration: 1.1.2017 - 31.12.2020

Influence of extreme conditions on strongly correlated electron systems
Vplyv extrémnych podmienok na silne korelované elektrónové systémy.
Program: VEGA
Project leader: Doc. RNDr. Gabáni Slavomír PhD.
Annotation:Strong correlations between free (conduction) and bound (localized) electrons in a condensed matter can be change or modified by extreme conditions (very low temperatures, high pressures and magnetic fields), what often leads to the creation of new/exotic states/effects in these materials. In this proposal, we will experimentally study the newest open problems in strongly correlated electron systems (SCES), as surface conductivity in topological Kondo insulators, dynamics of frustrated antiferromagnets, Kondo vs. spin-polaron model in spin glasses, superconductivity under pressure. All this will be a very time-consuming research on new-produced samples.
Duration: 1.7.2016 - 31.12.2019

Development of new procedures for the reconstruction and analysis of the data from the proton-proton collisions at the LHC
Vývoj nových postupov pre rekonštrukciu a analýzu dát z protón-protónových zrážok na urýchľovači LHC
Program: VEGA
Project leader: RNDr. Stríženec Pavol CSc.
Annotation:Theoretical as well as methodological contribution to studies of proton interactions at LHC accelerator, which was just upgraded to a new, so far the highest energy of proton-proton collisions, is proposed in this project. The project goal is to contribute to the improvements of existing reconstruction and analysis procedures, as well as to bring up new aspects from theoretical and methodological points of view. The main contribution to methodology will be the improvement of the hadronic calibration of the ATLAS calorimeter. Contribution to the accuracy improvement of b-jet charge calibration is also foreseen. We assume three main contributions to the analysis, namely improvements of the top-quark charge measurement, searches for Higgs boson and searches for Standard Model (SM) extensions, as well as to obtain improved data to study Bose-Einstein correlations between the pions produced in proton collisions.
Duration: 1.1.2016 - 31.12.2019

Projects total: 54