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Information Page of SAS Organisation

Project

Institute of Experimental Physics

International Projects

The ALICE experiment at the CERN LHC: Study of the strongly interacting matter under extreme conditions

Experiment ALICE na LHC v CERN: Štúdium silno interagujúcej hmoty v extrémnych podmienkach

Duration: 1. 1. 2022 - 31. 12. 2026
Evidence number:MŠVVaŠ SR 0409/2022
Program: CERN/MŠ
Project leader: RNDr. Králik Ivan CSc.
Annotation:The project is aimed at the study of strongly interacting matter under extreme conditions of the p-p, p-Pb and Pb-Pb collisions at the energies of the LHC collider at CERN. The main program of the ALICE experimemt is the study of the quark-gluon plasma properties.

ATLAS KE - ATLAS experiment at LHC at CERN: deep-inelastic phenomenons and new physics at TEV energies

Experiment ATLAS na LHC v CERN: hlboko-nepružné javy a nová fyzika pri TeV energiách

Duration: 1. 1. 2022 - 31. 12. 2026
Evidence number:MŠVVaŠ SR 0408/2022
Program: CERN/MŠ
Project leader: RNDr. Stríženec Pavol CSc.

CHINMULTIHIT - Discovery and Mechanism of Small Molecules from Traditional Chinese Herbs for Multitarget directed Therapy of Neurodegenerative Diseases

Identifikácia malých molekúl z tradičných čínskych bylín na multicieľovú terapiu neurodegenerat ívnych ochorení a objasnenie mechanizmu účinku

Duration: 1. 7. 2024 - 30. 6. 2026
Evidence number:SK-CN-23-0025
Program: Bilaterálne - iné
Project leader: doc. RNDr. Gažová Zuzana DrSc.
Annotation:Protein misfolding neurodegenerative diseases (NDDs), such as Alzheimer's and Parkinson's diseases, result in extensive cellular and neuronal loss within the central nervous system. Despite the distinct manifestations of these disorders, they share several common pathogenic mechanisms. Current pharmacological interventions are ineffective. Moreover, the complexity of NDDs necessitates innovative therapeutic approaches. In this project, the novel "multi-target-directed ligands" (MTDLs) strategy will be employed as it focuses on development of novel compounds modulating multiple factors simultaneously. We will focus on Chinese herbs - Angelica sinensis, Ligusticum chuanxiong, and Cinnamomum cassia. The project aims to explore the anti-aggregation potential of these herbal extracts and their derivatives targeting both Aβ peptide and α -synuclein, showcasing neuroprotective and anti-inflammatory properties to pave the way for the development of novel t herapeutic strategies for NDDs. The project combines the expertise and experience of both research teams in the field of protein misfolding and NDDs pathology, allowing us to acquire complex data with the aid of complementary approaches, leading to the suggestion of possible alternatives of therapy against these devastating diseases. Moreover, this collaborative research partnership will present an excellent opportunity for both teams' young members to learn new techniques in the well-equipped laboratories at East China University and IEP SAS and gain new experience by working in an international scientific environment.

LAMSoftMag - Laser Additive Manufacturing of Soft Ferromagnetic Metallic Glasses/ Composites

Laserová aditívna výroba magneticky mäkkých kovových skiel/kompozitov

Duration: 1. 7. 2024 - 30. 6. 2026
Evidence number:SK-AT-23-0025
Program: Bilaterálne - iné
Project leader: RNDr. Škorvánek Ivan CSc.

QUID-REGIS - Quiet Ionospheric Disturbances - REsearch based on Ground-based mesospheric and Ionospheric data with Swarm data

Narušenia pokojnej ionosféry - Výskum založený na pozemných meraniach mezosféry a ionosféry a na dátach z ESA misie SWARM

Duration: 1. 2. 2024 - 31. 12. 2026
Program: European Space Agency (ESA)
Project leader: RNDr. Mackovjak Šimon PhD.
Annotation:With this the QUID-REGIS project aims to improve the understanding of unexpected ionospheric variability during solar quiet periods. This is achieved by integrating data and knowledge of ionospheric variability with lower atmospheric dynamics. The project seeks to isolate the sources of variability and enhance comprehension of its underlying drivers by leveraging Swarm satellite data, ground-based airglow measurements, and the IRI model. Understanding these disturbances in the upper atmosphere has crucial implications for space weather forecasting and satellite communications, making QUID-REGIS a vital component of ongoing EO research.

ML4NGP - Non-globular proteins in the era of Machine Learning

Neglobulárne proteíny v ére strojového učenia

Duration: 25. 10. 2022 - 26. 10. 2026
Evidence number:COST Action CA21160
Program: COST
Project leader: RNDr. Bednáriková Zuzana PhD.
Annotation:The ML4NGP Action aims to establish an interdisciplinary pan-European network to favour interplay between experiments and computation, fostering experimental frameworks designed to provide information to computational methods, and novel computational methods developed, trained and benchmarked with experimental data. ML4NGP will enhance the primary experimental data generation (WG1), promote integrative structural biology approaches (WG2), benchmark the state-of-the-art ML methods (WG3) and improve the functional characterization of NGPs (WG4). The Action will support its scientific objectives through policies that sustain free knowledge exchange, inclusiveness and training of young researchers who will lead future innovations in this field.
Project web page:https://www.cost.eu/actions/CA21160/

NEPTUNE - Novel peptide‐based aggregation inhibitors as potential therapeutics for neurodegenerative diseases

Nové inhibítory amyloidnej agregácie na báze peptidov pre potenciálnu liečbu neurodegeneratívnych ochorení

Duration: 1. 7. 2025 - 30. 6. 2027
Evidence number:APVV DS-FR-24-0060
Program: Bilaterálne - iné
Project leader: RNDr. Bednáriková Zuzana PhD.
Annotation:Neurodegenerative disorders like Alzheimer’s disease (AD) and Parkinson’s disease (PD) are characterized by abnormal protein amyloid aggregation and subsequent neuronal loss. Current treatments provide limited efficacy, underscoring the urgent need for innovative strategies. This project proposes leveraging Late Embryogenesis Abundant Proteins (LEAPs) derived from resurrection plants as anti-aggregation agents for Amyloid β peptides and α-Synuclein, key proteins implicated in AD and PD. Our preliminary data demonstrate that LEAP candidates inhibit amyloid aggregation in vitro, validated through advanced spectroscopic and imaging techniques. We aim to recombinantly produce LEAPs, elucidate their binding mechanisms, and develop LEA-mimetic peptides with enhanced therapeutic potential. Employing in vitro assays and AD/PD-like C. elegans models, we will assess their anti-aggregation efficacy and cytotoxicity. This interdisciplinary collaboration integrates computational biology, biochemistry, and neurobiology to advance peptide-based therapies for neurodegenerative diseases.

PHOTON - Fabrication and Characterization of Protein-based Hydrogels with Rapid 3D Imaging via Advanced Nonlinear Optical Microscopy

Príprava a charakterizácia proteínových hydrogélov s 3D zobrazovaním pomocou pokročilej nelineárnej optickej mikroskopie

Duration: 1. 7. 2025 - 30. 6. 2027
Evidence number:APVV SK-TW-24-0005
Program: Bilaterálne - iné
Project leader: RNDr., Ing. Šipošová Katarína PhD.
Annotation:Proteins displaying remarkable structural and functional characteristics such as biocompatibility, biodegradability, abundance, and reduced ability to induce immune and tissue inflammatory responses possess great potential for the manufacture of hydrogels. In addition, all proteins have the potential to be cross-linked, therefore by employing physical, chemical, and enzymatic treatments, proteins have innate benefits for hydrogel-forming. Amyloidal proteins are a category of programmable self-assembled macromolecules, and their assembly and owing to the programmability of the self-assembly of amyloidal structures, the consequent nanostructure can be manipulated rationally. Moreover, self-assembly allows the co-assembly of two or more types of building blocks, resulting in increasingly structurally complex nano-assemblies that may have physical and chemical properties distinct from those of the original mono-structures. Therefore, in the crosslinking-controlled strategy, by changing the nature and concentration of proteins, the resulting physical-chemical properties of amyloid-inspired hydrogel can be rationally tuned. Motivated by this, the proposal is aimed at basic as well as applied research and is represented by two major goals: a) preparation of single (one)-type amyloid-based hydrogels; b) fabrication of mixed protein-hydrogels by entrapping DNA-protein hybrids that could lead to the developing new materials with unprecedented structural and functional features; (c) the application of advanced nonlinear optical microscopy for rapid 3D multiphoton fluorescence imaging and second harmonic generation imaging to investigate hydrogel structures; and (d) the integration of deep learning-based image enhancement techniques to improve 3D image quality and capture detailed structural information.

RETROTRAFO - Development of knowledge and technology to implement retrofilling in power ransformers using biodegradable or recycled fluids and fostering circular economy

Rozvoj znalostí a technológií na implementáciu dodatočného plnenia výkonových transformátorov s použitím biologicky odbúrateľných alebo recyklovaných kvapalín a podpora obehového hospodárstva

Duration: 1. 9. 2024 - 31. 12. 2027
Evidence number:101182948 (HORIZON-MSCA-2023-SE-01)
Program: Horizont Európa
Project leader: doc. RNDr. Kopčanský Peter CSc.

skQCI - skQCI

skQCI

Duration: 1. 1. 2023 - 30. 6. 2026
Evidence number: 10109154
Program: Digital Europe Programme
Project leader: RNDr. Skyba Peter DrSc.
Project web page:https://skqci.qute.sk/sk/slovencina/

ALCHyM - Investigation of Advanced Functional Materials based on Liquid Ctystals

Skúmanie pokročilých funkčných materiálov na báze kvapalných kryštálov

Duration: 1. 1. 2025 - 31. 12. 2028
Evidence number:SK-TW-RD-24-0007
Program: Bilaterálne - iné
Project leader: RNDr. Tomašovičová Natália CSc.
Annotation:The widespread acquaintance of liquid crystals (LCs) is based on today’s liquid crystal display technology. There are also other important devices (less well known to the public) relying on LCs like optical switches, photo-elasticmodulators, tunable lasers, tunable filters, etc. These devices take the use of the anisotropy (orientational dependence) in the optical, electric and magnetic properties of LCs for functioning. The proposal focuses on the exploration of transitions induced by external fields in LCs doped with magnetic, non-magnetic and photothermal conversion nanoparticles as well as their mixture. Transitions under the scope include phase and orientational transitions of such composite systems. The proposal has the ultimate goal to exploit the transitions under the scope in potential practical devices such as various magnetic/electric/optical/thermal sensors & actuators, and energy-related LC devices like smart windows, no-bias optically-compensated bend LC displays, bistable bendsplay LC displays.

JUICE-PEP-ACM - Slovak contribution to ESA-JUICE mission: Development of Anti-Coincidence Module ACM for Particle Environment Package PEP

Slovenský príspevok k misii ESA-JUICE: Vývoj anti-koincidenčného modulu ACM pre časticový komplex PEP

Duration: 15. 11. 2018 - 31. 12. 2026
Evidence number:ESA-PECS SK3-03
Program: European Space Agency (ESA)
Project leader: Ing. Baláž Ján PhD.
Annotation:The ESA’s JUICE (JUpiter ICy moons Explorer) mission (http://sci.esa.int/juice) have to face to very hostile environment of Jovian radiation belts where the penetrating energetic electrons dominate. The Particle Environment Package (PEP) payload of this mission (http://sci.esa.int/juice/50073-science-payload ) was developed within a wide international collaboration led by Swedish Institute for Space Physics IRF in Kiruna. Due to limited available mass for efficient radiation shielding, the PEP payload will operate in rather unfavourable environment of penetrating energetic electrons that will affect the detection process inside the PEP/JDC (Jovian plasma Dynamics and Composition) sensor. To mitigate the unfavourable influence of the penetrating electron radiation to the plasma ions detection process, a concept of anti-coincidence module (ACM) has been identified within the PEP consortium. The project involves development of space-flight grade semiconductor solid state detector, the processing electronic board and a laboratory testing and calibration system RATEX-J (RAdiation Test EXperiment for JUICE). The JUICE probe has been successfully launched 14.4.2023 from space port Kourou. The PEP science suite has been successfuly commissioned in June 2023. The JUICE probe will be inserted into the orbit around Jupiter on 18. July 2031.

SCALES - Superfluid Condensates in Astrophysics and Laboratory Experiments

Superfluid Condensates in Astrophysics and Laboratory Experiments

Duration: 1. 1. 2025 - 31. 12. 2027
Program: COST
Project leader: RNDr. Človečko Marcel PhD.

SUPERQUMAP - SUPERCONDUCTING NANODEVICES AND QUANTUM MATERIALS FOR COHERENT MANIPULATION

Supravodivé nanozariadenia a kvantové materiály pre koherentnú manipuláciu

Duration: 6. 10. 2022 - 5. 10. 2026
Evidence number:COST CA211444
Program: COST
Project leader: prof. RNDr. Samuely Peter DrSc., akademik US Slovenska
Annotation:We propose a collaborative approach joining together efforts and groups all over Europe, structured around three pathways, (i) the synthesis and characterization of quantum materials with novel topological properties, (ii) the fabrication of sensors and devices exploiting novel superconducting functionalities and (iii) the generation and coherent manipulation of superconducting states that can create new opportunities in the superconducting quantum electronics. Using an open and inclusive approach that joins expertise and capabilities all over Europe, this project will structure collaborative efforts aiming at disruptive achievements in the field of superconductivity. The results will impact far beyond the development of new quantum solutions for computation, and include sectors such as health and energy.

SUPRA-SIGHT - Exploring Protein Amyloid Superstructures and Dynamics Using Single-Molecule Microscopy with the Deep-Learning Modeling

Štúdium štruktúry a dynamiky supramolekulárnych amyloidných štruktúr jednomolekulovou mikroskopiou a modelovaním pomocou strojového učenia

Duration: 1. 1. 2025 - 31. 12. 2027
Evidence number:SAS-NSTC/ JRP/2024//SUPRA-SIGHT
Program: JRP
Project leader: RNDr., Ing. Šipošová Katarína PhD.
Annotation:Protein self-assembly processes independent of external energy sources and unlimited in-dimensional scaling have become a very promising approach for developing new materials with unprecedented structural and functional features. The best examples of self-assembled materials can be found in nature, including functional and pathological amyloid fibrils. Motivated by this, the proposal is aimed at basic as well as applied research and is represented by two major goals: a) anti-amyloid study - focusing on pathological amyloid aggregation connected with neurodegenerative diseases that will optimize the application of newly prepared compounds/particles in the treatment of amyloid-related diseases and enable imaging of amyloid formation/decomposition; b) fabrication of protein superstructures by chemical appending of functional ligands onto self-assembling peptides or proteins lays the foundation for developing new materials with unprecedented structural and functional features. Therefore, the development of the single-molecule orientation and localization microscopy (SMOLM), together with the deep-learning modeling for the localization and reconstruction of SMOLM images will help rapidly perfect the high-content analysis of the structural-morphological features not only the pathological amyloid aggregates but also superstructures consisting of amyloid scaffolds and connected bio-structures (DNA) and ligands. Moreover, the single-molecule orientation and localization microscopy could significantly contribute to understanding not only the process of protein self-assembly but also the mechanism of the binding and release of biologically active agents, formation and reorganization of multiple protein arrangements upon interaction with biologically relevant ligands/molecules.

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Topologický riadené samousporiadanie a nové multiferoické kvapaliny

Duration: 1. 1. 2025 - 31. 12. 2026
Evidence number:MAD SK-HU
Program: Medziakademická dohoda (MAD)
Project leader: RNDr. Tomašovičová Natália CSc.
Annotation:The proposal offers research on colloidal systems from the perspective of self-assembly (SA), where a form of overall order arises due to the local interactions between the components of an initially disordered system. SA has an indisputable importance in all fields of natural sciences, and has also a deep impact in social sciences (economics, sociology, anthropology, psychology, etc). Currently, one of the hot topics of the worldwide research is to design nanomaterials that are capable to assemble into functional superstructures in multiple directions. Besides the local ordering appearing spontaneously on the molecular level of SA materials, they may form micro/macroscopic superstructures via the appearance of topological defects (TDs). These local singularities are universal in nature, having great importance in many fields including cosmology, nanophysics, materials science, and particle physics. TDs can trigger phase transitions, attract/repulse each other, and trap foreign objects (particles). At the same time, particles dispersed in a SA matrix inevitably generate TDs around themselves. Therefore, in colloidal systems, a subtle interplay between micro/nano-particles, SA matrix and TDs drives the self-organization process. In line with the TD driven SA investigations, the discovery of ferroelectric nematic phase (NF) in 2017 offers the possibility to create novel multiferroic liquids by doping NF with nanoparticles, which we also intend to explore.

CR clouds - The role of cosmic rays in clouds formation

Úloha kozmického žiarenia vo formovaní mrakov

Duration: 9. 5. 2025 - 8. 6. 2027
Program: Iné
Project leader: RNDr. Bobík Pavol PhD.

RBS - Research on bulk superconductors

Výskum masívnych supravodičov

Duration: 1. 5. 2018 - 31. 12. 2026
Evidence number:1/2018
Program: Iné
Project leader: Ing. Diko Pavel DrSc., akademik US Slovenska
Annotation:The agreement on cooperation between IEP SAS and CAN Superconductorsis focused on research od REBCO bulk supercondyctors for practical applications.
Project web page:https://websrv.saske.sk/uef/oddelenia-a-laboratoria/laboratorium-materialovej-fyziky/

NOMAGRAD - Design of novel materials-based high performance magnetic gradiometer

Vývoj vysoko-citlivého magnetického gradiometra na báze nových magnetických materiálov

Duration: 1. 4. 2024 - 31. 3. 2027
Program: JRP
Project leader: RNDr. Škorvánek Ivan CSc.

PURPLEGAIN - Fundamentals and applications of purple bacteria biotechnology for resource recovery from waste

Základy a aplikácie purpurových baktérií v biotechnológií pre obnovu znečistených zdrojov

Duration: 10. 10. 2022 - 9. 10. 2026
Evidence number:COST Action CA21146
Program: COST
Project leader: RNDr. Pudlák Michal CSc.
Annotation:PURPLEGAIN aims to create a European network to share information, facilitating technology and knowledge transfer between the academic and industrial sectors, related to PPB applications for resource recovery from organic waste sources. Resource recovery includes wastewater or organic waste, open or closed environments, in single or chain processes. The network associates fundamental-focused and applied-research groups, improving lab-scale technology optimization through mechanistic modeling. It benefits the technology transfer from applied-research groups to industry, considerably improving process design.
Project web page:https://www.cost.eu/actions/CA21146/ https://purplegain.eu/

NexMPI - Magnetic Particle Imaging for next-generation theranostics and medical research

Zobrazovanie magnetických častíc pre teranostiku novej generácie a medicínsky výskum

Duration: 22. 10. 2024 - 21. 10. 2028
Evidence number:COST action CA23132
Program: COST
Project leader: RNDr. Kubovčíková Martina PhD.

National Projects

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Diskrétna gravitácia, kvantové javy a ich aplikácia na rôzne druhy fyzikálnej reality

Duration: 1. 1. 2023 - 31. 12. 2026
Program: VEGA
Project leader: RNDr. Pudlák Michal CSc.

Phase coherent physical systems

Fázovo koherentné fyzikálne systémy

Duration: 1. 12. 2024 - 30. 6. 2026
Evidence number:09I01-03-V04-00090
Program: Plán obnovy EÚ
Project leader: RNDr. Skyba Peter DrSc.

Functionalized magnetic nanoparticles for MRI imaging of drug distribution in the lungs in experimental acute respiratory distress syndrome (ARDS)

Funkcionalizované magnetické nanočastice pre MRI zobrazovanie distribúcie liečiva v pľúcach pri experimentálnom syndróme akútnej respiračnej tiesne (ARDS)

Duration: 1. 1. 2023 - 31. 12. 2026
Evidence number:VEGA 2/0049/23
Program: VEGA
Project leader: Ing. Koneracká Martina CSc.
Annotation:The current project is focused on the synthesis and functionalization of magnetic nanoparticles (MNPs) for MRI imaging of the drug N-acetylcysteine distribution in the lungs in experimental acute respiratory distress syndrome (ARDS). The first step will be to prepare a conjugate consisting of MNPs modified with functional groups suitable for drug conjugation. MNPs functionalization and drug conjugation will be optimized and studied by physicochemical methods such as UV/Vis and IR spectroscopy, microscopy, calorimetry or magnetic measurements. In the next phase, the conjugate will be analyzed by MRI and compared with the properties of commercially available MRI contrast agents. In the third step, the relevant ARDS model will be created, and the conjugate will be applied to the lungs. Finally, the conjugate will be imaged using optimized MRI techniques to study the drug distribution in the lungs in ARDS. The output items of the project have a direct application potential for clinical practice.

Functional magnetic/dielectric/multiferroic materials based on rare earth and transition metal oxides

Funkčné magnetické/dielektrické/multiferoické materiály založené na vzácnych zeminách a oxidoch tranzitívnych kovov

Duration: 1. 1. 2025 - 31. 12. 2027
Evidence number: 2/0004/25
Program: VEGA
Project leader: RNDr. Mihalik Marián CSc.

GEM2SPIN - Graphene encapsulated two-dimensional magnetic materials as a platform for spintronics devices

Grafénom zapúzdrené dvojrozmerné magnetické materiály ako platforma pre spintronické zariadenia

Duration: 1. 1. 2025 - 31. 8. 2026
Evidence number:09I05-03-V02-00071
Program: Plán obnovy EÚ
Project leader: RNDr. Gmitra Martin PhD.

Searching for states with spin-liquid properties in frustrated magnetic systems

Hľadanie stavov s vlastnosťami spinových kvapalín vo frustrovaných magnetických systémoch

Duration: 1. 1. 2025 - 31. 12. 2028
Evidence number:VEGA 2/0035/25
Program: VEGA
Project leader: RNDr. Jurčišin Marián PhD.
Annotation:The main aim of the present project is the study of the potential existence of states with spin-liquid properties in frustrated magnetic systems with various geometric structure (kagome, tetrahedral, octahedral, etc.) in the framework of exactly solvable models of the classical statistical mechanics on the corresponding recursive lattices. In the framework of the project, the magnetic and thermodynamic properties of such magnetic systems related to the frustration will also be studied (the existence of ground states with high macroscopic degeneracy, anomalous properties of the specific heat at low temperatures, etc.).

Identification of small molecule motifs effective to inhibit amyloid aggregation of conformationally diverse amyloidogenic proteins

Identifikácia štruktúrnych motívov malých molekúl schopných inhibovať amyloidnú agregáciu amyloidogénnych proteínov s rozdielnou konformáciou

Duration: 1. 1. 2025 - 31. 12. 2028
Evidence number:2/0141/25
Program: VEGA
Project leader: doc. RNDr. Gažová Zuzana DrSc.
Annotation:Amyloid-related diseases, including systemic lysozyme amyloidosis, Alzheimer's disease and diabetes melitus, are characterized by the amyloid aggregation of proteins with distinct conformations. This project aims to identify small molecules capable of reducing the amount of amyloid aggregates of poly/peptides with diverse native conformation. We will focus on both globular proteins (lysozyme and insulin) and intrinsically disordered protein(IDP) (Aß peptides and tau). The project's objectives include assessing the anti-amyloid potential of small molecules, evaluating their cytotoxicity, and elucidating the relationship between their structural motifs and anti-amyloid effects. Attention will be given to small molecules with key structural motifs identified in our previous studies (a conjugated system of aromatic rings, a catechol moiety, planarity, and carboxyl groups) and their hybrid complexes. Thus, the project could pave the way for the development of novel therapeutics for amyloid-related diseases.

Intelligent micromanipulation with flexible tools controlled by laser traps.

Inteligentná mikromanipulácia pomocou pružných nástrojov ovládaných laserovými pascami.

Duration: 1. 1. 2025 - 31. 12. 2027
Evidence number: 2/0055/25
Program: VEGA
Project leader: doc. Ing. Tomori Zoltán CSc.
Annotation:A laser beam focused on a transparent particle floating in a fluid can hold it in place or move it in the desired direction by the force effects of photons. Using the method of two-photon polymerization a microscopic structure with several spherical transparent parts can be created, each focused by separate laser beam. With intelligent control of beams, we can achieve micromanipulation with the entire structure. The project solves problems of intelligent micromanipulation, performing the required tasks autonomously, but with the possibility of interactive cooperation with an operator. We plan 3 types of microtools and corresponding algorithms: a) a tool with flexible jaws for transporting cells to a container designed to measure the mutual transmission of signals between individual cells, b) a tool rotating in a fluid supplied with flexible fibers with the ability to measure their deformation, c) ball-shaped tool on flexible filament suitable for viscosity measurement.

APBC - The Advanced Protein Biotechnology Consortium: A Model for Fostering Economic Growth and Mitigating Brain Drain in Eastern Slovakia

Konzorcium pokročilých proteínových biotechnológií: Model pre podporu ekonomického rastu a zmiernenie úniku mozgov na východnom Slovensku

Duration: 1. 3. 2025 - 31. 8. 2027
Evidence number:09I02-03-V01-00021
Program: Plán obnovy EÚ
Project leader: doc. RNDr. Gažová Zuzana DrSc.

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Kvantová spinová dynamika nízkorozmerných systémov

Duration: 1. 1. 2025 - 31. 12. 2028
Evidence number:VEGA 1/0298/25
Program: VEGA
Project leader: RNDr. Vargová Hana PhD.

Tunable structures in ferromagnetic cholesteric liquid crystals

Laditeľné štruktúry vo feromagnetických cholesterických kvapalných kryštáloch

Duration: 1. 1. 2024 - 31. 12. 2027
Evidence number:2/0061/24
Program: VEGA
Project leader: doc. RNDr. Kopčanský Peter CSc.

AMYSTAP - -

Ligandy na báze aminokyselín ako stabilizátory amyloidogénnych proteínov (AMYSTAP)

Duration: 1. 7. 2025 - 30. 6. 2029
Evidence number:401101C479
Program: Európsky fond regionálneho rozvoja (EFRR)
Project leader: doc. RNDr. Gažová Zuzana DrSc.

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Magnetická frustrácia a kvantové oscilácie v kvázi 2D a 3D boridoch

Duration: 1. 1. 2024 - 31. 12. 2027
Evidence number:2/0034/24
Program: VEGA
Project leader: doc. RNDr. Gabáni Slavomír PhD.
Annotation:Borides form a broad class of materials with diverse physical properties. Metallic geometrically frustrated magnetic tetraborides (REB4), where RE represents an element from the rare earth group, are quasi-2D frustrated systems with different anisotropy strength and the same crystal lattice. These systems form an ideal environment for studying the connections between anisotropy and magnetization processes. With the help of the deviation of the magnetic field from the easy axis of magnetization, it will be possible to observe those components of inter-spin interactions that do not appear when the field is oriented in the direction of the easy axis, which will contribute to the development of more accurate theoretical models. By studying quantum oscillations in SmB6, which is considered to be a representative of strongly correlated topological systems, and in other selected hexaborides, it will be possible to contribute original results to the long-standing debate whether SmB6 is a topological insulator or not.

Soft magnetic nanocrystalline materials prepared by unconventional thermal processing techniques

Magneticky mäkké nanokryštalické materiály pripravené nekonvenčnými technikami tepelného spracovania

Duration: 1. 1. 2023 - 31. 12. 2026
Evidence number:2/0148/23
Program: VEGA
Project leader: RNDr. Škorvánek Ivan CSc.

MAMOTEX - Magnetically modified textiles

Magneticky modifikovaný textil

Duration: 1. 7. 2023 - 30. 6. 2027
Evidence number:APVV-22-0060
Program: APVV
Project leader: doc. RNDr. Kopčanský Peter CSc.

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Mezoškálové javy v systémoch polymérnych a nepolymérnych látok a metodológia skúmania

Duration: 1. 1. 2023 - 31. 12. 2026
Evidence number:VEGA 2/0071/23
Program: VEGA
Project leader: RNDr. Sedlák Marián DrSc.

NANOFLIT - Nano-functionalization of liquids for liquid-immersed transformers

Nano-funkcionalizácia kvapalín pre olejové transformátory

Duration: 1. 7. 2023 - 30. 6. 2027
Evidence number:APVV-22-0115
Program: APVV
Project leader: RNDr. Rajňák Michal PhD.
Annotation:The current increase in electricity consumption and the greening of its distribution, together with the increase in the price of materials for the production of distribution transformers, represent a challenge for applied research in electric power engineering. The intention of the presented project is to respond to this challenge by functionalizing the current liquids used in electrical transformers in order to increase their cooling efficiency while maintaining or improving their dielectric and insulating properties. For this project, the liquids used in the distribution transformers of the manufacturer interested in this research will be selected. These are commercial liquids primarily based on liquefied natural gas, synthetic and natural esters. Based on current state of the art, the liquids will be functionalized by means of nanotechnologies and nanomaterials, which can significantly improve thermal conductivity, natural and thermomagnetic convection, and thus make the overall heat transport in the liquids more efficient. The functionalizing nanoadditives will be mainly made from carbon (fullerene, nanodiamond) and iron oxides or other ferromagnetic elements. The functionalized liquids will undergo laboratory measurements of physico-chemical, electrical, magnetic and thermal properties. Based on the analyzes of laboratory experiments and numerical simulations, nanofluids with the greatest potential for improving the thermal and insulating properties of the transformer will be selected. The selected nanofluids will be tested by the industrial partner (the customer of the research results) and applied in the selected distribution transformer. The transformer will be subjected to electrical and temperature rise tests. One can expect that the nanofunctionalization of the liquids will result in a lower operating temperature of the transformer, which can lead to an extension of the transformer service life and to the production of smaller transformers.

Non-centrosymmetric superconductors

Necentrosymetrické supravodiče

Duration: 1. 1. 2024 - 31. 12. 2027
Evidence number:2/0073/24
Program: VEGA
Project leader: RNDr. Kačmarčík Jozef PhD.

LSD - Low-dimensional Superconducting Devices

Nízkorozmerné supravodivé aparáty

Duration: 1. 9. 2024 - 31. 12. 2027
Evidence number:APVV-23-0624
Program: APVV
Project leader: Mgr. Szabó Pavol CSc.
Annotation:Ultralow temperatures have become an important tool for new research avenues in nanoscience, materials research and particularly in quantum nanotechnologies. Scaling down a physical system towards the sizes when the quantum properties surpass classical physics opens a plethora of new quantum-driven effects, thus giving rise to new classes of quantum materials. Within the proposed project we will focus our study on low-dimensional quantum devices, heterostrucures consisting of atomically thin superconducting slabs and aditional layers with different order (inslulator, metal, ferromagnet). In such systems symmetries can be broken possibly allowing for non trivial topological quantum states relevant for future technologies. Atomically thin layered materials are systems with zero limit bulk-to-surface ratio. Their physical properties are strongly affected by interfacing with other systems. Therefore, they represent an accessible platform for the abundance of quantum effects that can be engineered by combining them into vertical stacks using exfoliation techniques. One identifies two types of layered systems – atomically thin artificially prepared van der Waals heterostructures [Science 353, aac9439 (2016)], and naturally layered three-dimensional crystal systems. A special class of naturally layered materials is misfit structures combining alternating atomic layers of hexagonal transition metal dichalcogenides and slabs of ionic rare-earth monochalcogenides in the same superlattice [APL Mater 10, 100901 (2022)]. They feature new state of quantum matter, the Ising superconductivity resulting from broken inversion symmetry and strong spin-orbit coupling as has been recently shown by us. The misfits are also exfoliative and thus incorporable as units in vertical stacks.

ROTOLES - Optimised growth and the transport and optical properties of thin layers of selected topological semimetals

Optimalizovaný rast a transportné a optické vlastnosti tenkých vrstiev vybraných topologických polokovov

Duration: 1. 7. 2024 - 30. 6. 2027
Evidence number:APVV-23-0564
Program: APVV
Project leader: prof. RNDr. Samuely Peter DrSc., akademik US Slovenska
Annotation:One of the fundamental results of quantum mechanics in the 1920s was the derivation of relativistic equations for massive fermions (Dirac), massless fermions (Weyl) and fermions that are themselves antiparticles (Majorana). Since those times, particle physics has been searching for particles representing Weyl and Majorana's fermions. However, their search has not yet been successful. In the last twenty years, it has been shown that the band structure of some materials has such unique characteristics that the charge carriers in them can behave according to the dynamics satisfying the Dirac or Weyl relativistic equations. Such materials include compounds from the group of transition metals dichalcogenides, which we will focus on in our project. We will work with very thin layers of selected materials from this group, such as PtSe2, MoTe2 and WTe2. The first step in the implementation of the project will be the preparation of such layers by chalcogenisation of thin films of transition metals. Their transport and optical properties will then be thoroughly investigated. Temperature-dependent transport measurements can show us transitions between different structures of the same material. We expect that a metal-insulator transition can be observed when the thickness of such thin films is varied. Some of these materials can go into a superconducting state at very low temperatures. We will also try to induce this state in close proximity, i.e. when the thin layer is in contact with another superconductor. Optical measurements will be correlated with transport measurements. We derive essential frequency-dependent characteristics, such as optical conductivity, from the latter. We will look for characteristics theoretically predicted for Dirac and Weyl fermions in the optical conductivity.

IMAGIN - Impact of magnetic quantum and thermal phase transitions on technological innovations

Prínos magnetických kvantových a teplotných fázových prechodov pre technologické inovácie

Duration: 1. 9. 2025 - 31. 8. 2029
Evidence number:APVV-24-0091
Program: APVV
Project leader: RNDr. Vargová Hana PhD.
Annotation:This project aims to explore the fundamental properties and technological potential of thermal and quantum phase transitions in low-dimensional quantum magnetic systems. To address these highly topical challenges emerging at the intersection of quantum magnetism and quantum information science, we will employ state-of-the-art analytical and numerical computational methods including exact mapping transformations, localized-magnon theory, exact diagonalization, classical and quantum Monte Carlo simulations, density-matrix renormalization group method, tensor-network techniques, etc. A primary focus will be on optimizing the cooling efficiency of magnetocaloric cycles near phase transitions of 2D quantum magnets, which could contribute to the development of energy-saving cooling technologies crucial for quantum computers based on superconducting qubits. Additionally, we will investigate the stability and phase transitions of skyrmion phases in frustrated triangular antiferromagnets with possible implications for spintronic applications. Another key objective is to study topologically nontrivial quantum states, particularly cluster-based Haldane states and bound magnons in frustrated quantum spin systems, which may provide promising platforms for quantum computing, quantum information storage and processing. Furthermore, we will also explore the optimization of quantum heat engines based on magnetic spin systems assessing their efficiency for energy conversion and quantum batteries. Another specific task of the project is the study of quantum entanglement and quantum phase transitions in fractal lattices with the aim to uncover the impact of complex lattice geometries on quantum correlations and critical phenomena.

SUSTAIN - Processing and performance of critical-elements-free hard and soft magnetic materials for sustainable development

Príprava a vlastnosti magneticky tvrdých a mäkkých materiálov bez kritických prvkov pre trvalo udržateľný rozvoj

Duration: 1. 7. 2024 - 31. 12. 2027
Evidence number:APVV-23-0281
Program: APVV
Project leader: RNDr. Škorvánek Ivan CSc.

SelfNano - Programmable self-organization of hybrid DNA-protein nanosystems for controlled binding and release of biologicals

Programovateľné samo-usporiadanie hybridných DNA-proteín nanosystémov pre kontrolovateľné viazanie a uvoľnovanie biologicky aktívnych látok

Duration: 1. 7. 2024 - 30. 6. 2028
Evidence number:APVV-23-0013
Program: APVV
Project leader: RNDr., Ing. Šipošová Katarína PhD.
Annotation:Protein self-assembly is a process based on autonomous, non-covalent interactions between distinct building blocks without requirement of external energy sources. The possibility of chemical appending of functional ligands onto self-assembling peptides or proteins lays the foundation for developing new materials with unprecedented structural and functional features. Especially using sequence addressable DNAs, the synergistic combination into DNA-protein self-assembling systems, may lead to unique and sophisticated functional hybrid nanostructures, which are highly programmable and display remarkable features that create new opportunities to build materials on the nanoscale. Inspired by the unique ability of proteins to self-assemble into amyloid fibrils, we plan to use recombinant spider silk eADF4(C16) protein, insulin, Aβ peptide and lysozyme in order to demonstrate the versatility of the concept of DNA-assisted self-organization of higher-order fibrillar structures. We will explore two dynamic association modes, the temperature-controlled hybridization event of short overlapping DNA sequences and the highly specific DNA-aptamer-to-ligand binding controlled by the ligand affinity. Generally, we foresee the feasibility of the proposed nanofibrillar systems mate of DNA-protein hybrids for the construction of nanostructured materials in biomedical research for binding and release of biologically active agents, formation of multiple protein arrangements for efficient enzymatic cascades or even dyes positioning for efficient light harvesting systems.

Progressive magnetic emulsions

Progresívne magnetické emulzie

Duration: 1. 1. 2025 - 31. 12. 2028
Evidence number:2/0028/25
Program: VEGA
Project leader: Ing. Molčan Matúš PhD.
Annotation:Pickering emulsion (PE) is an emulsion stabilized by solid particles accumulated at the surface of droplets. New emulsions with additive properties such as magnetism are emerging. To stabilize PE, ferromagnetic iron oxide particles can be used, with magnetic nanoparticles composing the droplet shells. The magnetic shell of Pickering droplets allows response to magnetic manipulation. Research tasks involve the preparation of magnetic particles (spherical, core-shell, magnetosomes) and their functionalization, studying primary magnetic and structural properties (particle size, surface modification, hydrophobicity/hydrophilicity, and stability). Subsequently, the particles will be used to prepare magnetic PE. A novel approach to emulsion production using ultrasound and electric fields will be employed. The impact of particles on the properties of emulsions will be investigated: magnetic, dielectric, rheological, and ultrasonic. Verifying their heating effect under alternating magnetic fields will also be crucial.

MikroFlex - -

Pružné mikroštruktúry a mikroroboty pre biomedicínske labon-chip aplikácie

Duration: 1. 7. 2022 - 30. 6. 2026
Evidence number:APVV-21-0333
Program: APVV
Project leader: doc. Ing. Tomori Zoltán CSc.
Annotation:The development boom of biomedical lab-on-chip (LOC) applications during the last two decades brought the need for the miniaturization of conventional mechanical actuators, sensors, and manipulators. Light-driven mechanical microstructures, trapped and moved by optical tweezers, can be easily integrated into the microfluidic LOC environment. The vast majority of light-driven microstructures is prepared by two-photon polymerization. It is the main objective of the present project to exploit the possibilities of working with flexible (deformable) microstructures, which were not used in biomedical applications, yet. Two well-defined LOC application areas are targeted: micro-rheology and single-cell manipulation. Micro-viscometers utilizing the effect of the surrounding fluid medium on the deformation (deflection) of flexible micro-cantilevers will be developed. The novel viscometer devices will be either anchored to the bottom glass surface or kept mobile and optically transportable inside the micro-fluidic system. Light-driven elastic micro-robots will be designed and tested for capture, transport, and release of single live cells. The operation of the developed micro-manipulators will be automated to build multicellular systems, mimicking the tissue conditions, in an autonomous way. To facilitate the flexible microstructure development and optimization, the material properties of the photo-polymers will be determined by comparing experimental deformation data with the results of numerical simulations.

REBCOAPL - -

REBCO masívne supravodiče na báze Y, Gd, Sm a Eu pre praktické aplikácie

Duration: 1. 7. 2022 - 30. 6. 2026
Evidence number:APVV-21-0387
Program: APVV
Project leader: Ing. Diko Pavel DrSc., akademik US Slovenska
Annotation:The project is focused on research and development of selected REBCO bulk singlegrain superconductors (BSS). We will examine YBCO, GdBCO, SmBCO and EUBCO systems, which are currently preferred in terms of mastering their production technology and specific applications. Based on our latest results, we will focus on the alloying of LREBCO (LRE- light rare earths) with elements that suppress Ba/LRE substitution in the crystal lattice, the addition of nanocrystalline BaCeO3, the bimodal size distribution of pining centres and the configuration of holes in REBCO BSS. We will apply the research results in the development of BSS production technology with optimized superconducting and mechanical properties. The use of the research and development results achieved within the project is expected by the manufacturer BSS CAN Superconductors s.r.o.
Project web page:https://websrv.saske.sk/uef/oddelenia-a-laboratoria/laboratorium-materialovej-fyziky/

Slovak Technical Ecosphere Platform

Slovenská technická ekosférická platforma

Duration: 1. 4. 2025 - 30. 9. 2027
Evidence number:09I02-03-V01-00038
Program: Plán obnovy EÚ
Project leader: RNDr. Mackovjak Šimon PhD.
Annotation:STEPHANIK aims to establish a nationally and internationally competitive ecosystem for modular satellite technologies in Slovakia by: • developing and validating modular satellite building blocks up to TRL 2–4, • building a network of joint laboratories and cleanroom facilities across partner institutions, • creating a talent pipeline of highly skilled space engineers, researchers and operators, • creating conditions for systematic import of international excellence into Slovak space research, • enabling future flight missions and commercial exploitation by Slovak academic and industrial partners.
Project web page:https://stephanik.eu

SPIN-DIME - Spin injection into diamond for quantum magnetoelectronics

Spin injection into diamond for quantum magnetoelectronics

Duration: 1. 11. 2025 - 30. 10. 2030
Evidence number:IM-2024-121
Program: IMPULZ
Project leader: prof. RNDr. Samuely Peter DrSc., akademik US Slovenska

R1-Kareem Abdul - Misfolding proteins in amyloid diseases and their prevention/therapy

Štipendiá pre excelentných PhD. študentov a študentky (R1) – UEF SAV

Duration: 1. 9. 2023 - 30. 6. 2026
Evidence number:09I03-03-V02-00039
Program: Plán obnovy EÚ
Project leader: MTech. Kareem Hanan Abdul

2D-MAP - 2D magnetism: probing and controlling magnetic states in 2D layered materials

Štipendiá pre excelentných výskumníkov a výskumníčky R2-R4 (2D magnetizmus: skúmanie a riadenie magnetických stavov v 2D vrstvených materiáloch)

Duration: 1. 9. 2024 - 31. 8. 2026
Evidence number:09I03-03-V04-00304
Program: Plán obnovy EÚ
Project leader: RNDr. Orendáč Matúš PhD.
Annotation:This research project explores the magnetic properties of quasi-2D and 2D layered materials, with a focus on tetraborides and kagome systems. The study aims to uncover the fundamental origins and dynamic behaviors of magnetism in these materials by using experimental investigations and theoretical modeling. Additionally, this research aims to explore the potential applications of these materials in advanced technologies such as recording devices, spintronics, and piezoelectric systems. To achieve these objectives, the project involves mastering the fabrication of novel 2D heterostructures through an innovative stamping technique, enabling precise control over material properties and interfaces. By improving our understanding of 2D materials and their magnetic properties, this research contributes to the fields of frustrated magnetic systems and quantum-2D magnetism.

MagNaFs - Magnetic nanoflowers for biomedical applications

Štipendiá pre excelentných výskumníkov a výskumníčky R2-R4 (Magnetické nanokvety pre biomedicínske aplikácie)

Duration: 1. 9. 2024 - 31. 8. 2026
Evidence number:09I03-03-V04-00296
Program: Plán obnovy EÚ
Project leader: RNDr. Khmara Iryna PhD.
Annotation:Today, nanoscale materials are of great interest for their potential to be used in a wide range of areas, especially in biomedical applications such as detection, early diagnosis and effective treatment of oncological disease. One of the therapies that are actively being developed is magnetic hyperthermia (MH) as an alternative approach for the local treatment of tumours. MH utilizes the heat generated by the magnetic nanoparticles (MNPs) when are subjected to an alternating magnetic field. Thus, the better MNPs are heated, the lower concentration of MNPs in the cancer tissue is required resulting in reducing the risk of side effects. Therefore, the heating ability and heating rate of these MNPs is extremely important. In this regard, the clustering of MNPs into nanoflowers, novel systems in terms of morphology showing a structure similar to a flower, can improve their heating rate of these MNPs is extremely important. In this regard, the clustering of MNPs into nanoflowers, novel systems in terms of morphology showing a structure similar to a flower, can improve their heating characteristics compared to their building blocks, i.e. monocrystals of MNPs and thus increase the heating efficiency of MH.

SASiFER-LC - Self-assembled structures in ferromagnetic liquid crystals

Štipendiá pre excelentných výskumníkov a výskumníčky R2-R4 (Samousporiadané štruktúry vo feromagnetických kvapalných kryštáloch)

Duration: 1. 9. 2024 - 31. 8. 2026
Evidence number:09I03-03-V04-00298
Program: Plán obnovy EÚ
Project leader: RNDr. Lacková Veronika PhD.

EXGRAV - Exploring discrete gravity, muon magnetic moment anomaly, and the black hole information paradox

Štipendiá pre excelentných výskumníkov a výskumníčky R2-R4 (Skúmanie diskrétnej gravitácie, anomálneho magnetického momentu miónu a informačného paradoxu čiernych dier)

Duration: 1. 11. 2024 - 31. 8. 2026
Evidence number:09I03-03-V04-00356
Program: Plán obnovy EÚ
Project leader: RNDr. Pinčák Richard PhD.

BEAST - Influence of synthesis parameters on the structure and properties of bulk high-temperature EuBCO-Ag superconductors applied in medical technologies

Štipendiá pre excelentných výskumníkov a výskumníčky R2-R4 (Vplyv parametrov syntézy na štruktúru a vlastnosti masívnych vysokoteplotných EuBCO-Ag supravodičov využiteľných v medicínskych technológiách)

Duration: 1. 9. 2024 - 31. 8. 2026
Evidence number:09I03-03-V04-00303
Program: Plán obnovy EÚ
Project leader: Mgr. Kuchárová Veronika PhD.

Study of elementary magnetization processes of powder compacted and composite materials.

Štúdium elementárnych magnetizačných procesov v práškových kompaktovaných a kompozitných materiáloch

Duration: 1. 1. 2024 - 31. 12. 2027
Evidence number:VEGA 1/0016/24
Program: VEGA
Project leader: RNDr. Kováč Jozef CSc.
Annotation:The project is focused on the experimental study of elementary magnetization processes, especially on domain walls displacements, in powder compacted and composite materials based on 3d transition metals. In this class of magnetic materials, the influence of individual electrically and magnetically non-insulated or isolated particles on the magnetization processes of surrounding particles significantly affects their magnetic properties. In the case of using electro-insulating materials with suitable magnetic materials, the mutual interaction of ferromagnetic particles can be significantly affected. The magnetization processes are in some cases different than that in usual materials prepared by conventional casting. Considering the class of materials prepared by compaction of isolated or non-insulated particles is becoming increasingly important, the knowledge of these peculiarities is useful in developing 3D materials for practical use in electrotechnology.

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Štúdium vysokoenergetických kozmických lúčov z vesmíru a ich interakcie s atmosférou Zeme pomocou neutrínových teleskopov

Duration: 1. 1. 2025 - 31. 12. 2027
Evidence number:VEGA 2/0124/25
Program: VEGA
Project leader: RNDr. Pastirčák Blahoslav CSc.

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Teoretické štúdium vlastností geometricky a interakčne frustrovaných magnetických systémov

Duration: 1. 1. 2023 - 31. 12. 2026
Program: VEGA
Project leader: RNDr. Jurčišinová Eva PhD.

TopoSQ2D - Topological superconductivity in quantum two-dimensional devices

Topologická supravodivosť v kvantových dvojrozmerných zaradieniach

Duration: 1. 4. 2022 -
Evidence number:IM-2021-42
Program: IMPULZ
Project leader: RNDr. Gmitra Martin PhD.
Annotation:The project aims to explore quantum physics in van der Waals 2D materials focusing on discovery of emergent quantum phenomena induced by the spin-orbit coupling and its interplay with magnetism, topology and superconductivity. For this purpose we establish a new Quantum Materials research laboratory with tightly merged theoretical expertise in spin-orbit coupling and experimental expertise in superconductivity. Research will be focused on investigating electronic properties of the prepared heterostructures in normal and superconducting phases using scanning tunneling microscopy and magnetotransport measurements. The theory will be intended for calculation of electronic structure from first-principles and quasiparticle interference spectra and transport properties in order to interpret experimental results and guide further experiments. The studied systems will be further recast towards proof-of-principle devices utilizing topological aspects of superconductivity relevant for quantum computations.

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Viaczložkové ligandy ako modulátory cieľov spojených s patogenézou Alzheimerovej choroby

Duration: 1. 7. 2023 - 30. 6. 2027
Program: APVV
Project leader: doc. RNDr. Gažová Zuzana DrSc.

STRIPEX - Influence of dynamic charge stripes on quantum magnets and superconductors in extreme conditions

Vplyv dynamických nábojových pásov na kvantové magnety a supravodiče v extrémnych podmienkach

Duration: 1. 7. 2024 - 30. 6. 2028
Evidence number:APVV-23-0226
Program: APVV
Project leader: doc. RNDr. Gabáni Slavomír PhD.
Annotation:The project is aimed at solving the urgent fundamental problem of the genesis of the so-called of dynamic charge stripes (DCS) - inhomogeneous distribution of conduction electron oscillations - and their influence on the properties of strongly correlated electron systems (SCES). The charge stripes play an important role in the high-temperature superconductivity (HTSC) of cuprates and also underlie the mechanisms responsible for the colossal magnetoresistance in manganites, cobaltites, iron-based HTSCs, etc. Observing directly the effect of DCS on the scattering of charge carriers in the mentioned SCES is very sophisticated due to their complex composition, low symmetry of the crystal structure and high sensitivity to external conditions. Instead, it is suitable to use model SCES. Such model materials are rare earth dodecaborides (RB12) with Jahn-Teller structural instability and electronic phase separation on the nanoscale range, in which the appearance of dynamic charge stripes was reliably determined for the first time both for superconductors (ZrB12, LuB12) and for quantum magnets (R = Ho, Er, Tm). The comprehensive study of DCS will be extended by additional model systems based on hexaborides (RB6) and frustrated quantum magnets based on rare earth tetraborides (RB4), and will includes the influence of external extreme conditions such as very low temperatures, high magnetic fields and pressures.

Enhancement of superconducting parameters in high-entropy alloy thin films

Vylepšenie supravodivých parametrov vysoko-entropických zliatin tenkých filmov

Duration: 1. 1. 2024 - 31. 12. 2027
Evidence number:2/0091/24
Program: VEGA
Project leader: RNDr. Pristáš Gabriel PhD.
Annotation:Superconducting materials have become an integral part of the latest technologies such as quantum computers, single-photon detectors, magnetic resonance, SQUID, etc. Achieving room-temperature superconductivity is no more the only goal, but targeted improvement of superconducting parameters (upper critical field, critical temperature) for application needs is the key. Extreme conditions in the form of very low temperatures, high pressures and reduction dimensions into quasi-two dimensions are very powerful tools in this endeavor. In particular, in case of thin films the superconducting properties can be tuned by several external parameters (e.g. film thickness, substrate, interfaces). The main goal of the project is to improve superconducting parameters of the high-entropy alloys and other materials in the form of thin films in purpose for use in future quantum applications technology.

Colonanobiocon - Exploitation of natural substances conjugated with magnetic nanocarriers in diagnostics and treatment of colon cancer

Využitie prírodných látok konjugovaných s magnetickými nanonosičmi v diagnostike a liečbe karcinómu hrubého čreva

Duration: 1. 9. 2025 - 31. 8. 2029
Evidence number:APVV-24-0448
Program: APVV
Project leader: Ing. Koneracká Martina CSc.
Annotation:Cancer is the second leading cause of death globally, therefore, considerable worldwide research is in progress to develop new drugs, diagnosis and therapy methods for cancer treatment. In this project proposal, we will firstly focus on design and synthesis of a multifunctional magnetic nanoparticle system consisting of a natural biologically active substance conjugated on magnetic nanoparticles (nanobioconjugate) and, secondly, on evaluation of their diagnostic and therapeutic potential for the application in oncology. The first step to achieve the desired goals will be the synthesis of magnetic nanoparticles and the functionalization of their surface with suitable biocompatible materials. Several physicochemical methods will be used to characterize and to optimize the preparation of multifunctional magnetic nanoparticles (magnetic NPs). The key step of the project will be immobilization of natural biologically active substances on magnetic NPs to form nanobioconjugate for cancer targeting and drug delivery. Considering the goal of the project, nanobioconjugate anticancer efficiency will be tested using colorectal carcinoma models in vitro and in vivo, as well. The project is based on a complex multidisciplinary approach, ranging from physics, and chemistry up to biophysics, biochemistry and biomedicine. The involved partners possess key skills, infrastructure and are highly motivated to reach the project goals.

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Získavanie energie magnetickými kvapalinami

Duration: 1. 1. 2024 - 31. 12. 2027
Evidence number:VEGA 2/0029/24
Program: VEGA
Project leader: RNDr. Rajňák Michal PhD.

Projects total: 64