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The list of international projects SAS

Institute of Parasitology
Relationships between functional diversity and food production and quality under ecological intensification
Funkčná biodiverzita, výroba potravín, ekologické poľnohospodárstvo a vzťahy medzi nimi.
Program: ERANET
Project leader: Ing. Čerevková Andrea PhD.
Annotation:Agricultural intensification contributes to global food security and health by supplying the food demand of a growing human population, but also causes environmental problems. Ecological intensification has been proposed as viable alternative to achieve a balance between negative environmental issues, such as the ongoing loss of biodiversity, and sufficiently high and qualitative food production. The functional diversity of biotic communities is an understudied dimension of biodiversity which may be particularly relevant for the links between ecological intensification, biodiversity, pollination, pest control and human food and livestock fodder production. Previous studies addressed the effects of ecological intensification on the functional diversity of single taxonomic groups in individual countries without considering links between functional diversity and plant, animal or human health across different landscapes and climatic regions. FunProd will undertake the joint synthesis of existing databases on these aspects in organic agriculture and permanent grasslands in Europe to provide a significant contribution to the evidence base for such links across different climatic regions and a range of landscapes. Closing this knowledge gap will contribute to the development of nature-based agricultural systems that provide simultaneously high levels of plant protection and health, together with sufficient productivity and quality to support the global human population, all while reducing environmental impact of agriculture. To this end, FunProd will address the following specific questions: • Does ecological intensification enhance the functional diversity of biotic communities across taxonomic groups compared to conventional intensification and does the effect depend on climatic conditions, landscape structure and/or agricultural system? • Does the effect of ecological intensification on the functional diversity of local communities explain the observed effect of ecological intensification on crop protection, pollination and health? Can a high functional diversity reduce the yield gap between agricultural production systems that focus on ecological and conventional intensification in Europe, and thereby contribute to future food security and quality?
Duration: 1.1.2020 - 31.1.2022
In vivo activity of silymarin flavonolignans on model infection induced with cestode Mesocestoides vogae in mice.
In vivo aktivita silymarínových flavonolignanov na modelovú infekciu vyvolanú pásomnicou Mesocestoides vogae u myší.
Program: Inter-academic agreement
Project leader: RNDr. Hrčková Gabriela DrSc.
Annotation:Medically important species of cestodes Echinococcus multilocularis, E. granulosus, Taenia solium cause serious diseases in various hosts, while humans can be infected accidentally. It is estimated that millions of people suffer from these disease mostly in resource-poor communities worldwide with limited therapeutic possibilities. Infection with cestode Mesocestoides vogae shares many pathological and molecular similarities with these diseases and was recommended by WHO (1996) as a suitable model in pharmacological, molecular and immunological studies. Silymarin represents mixture of flavonolignans, namely silybin, isosilibyn A, silydianin and silychristin. The pleiotropic mode of action of silymarin (antioxidant, antifibrotic, immunomodulatory, anti-cancer) has been reported but cestocidal potential of silymarin flavonolignans has not been studied in vivo. Recently we have demonstrated profound larvicidal activity due to interference with metabolic and enzymatic pathways in M. vogae larvae. The objective of present project is to reveal complex effects of individual flavonolignans during M. vogae infection in BALB/c mice.
Duration: 1.1.2018 - 31.12.2021
Classical and molecular karyology of Diphyllobothrium parasites: detection of phylogenetically informative markers.
Klasická a molekulárna karyológia parazitov rodu Diphyllobothrium: detekcia fylogeneticky významných charakteristík.
Program: Inter-academic agreement
Project leader: RNDr. Orosová Martina PhD.
Annotation:The current project is focused on cytogenetic research of medically important zoonotic parasites of the genus Diphyllobothrium. Karyotypes will be described in selected representatives and macro- and microstructure of chromosomes will be analyzed using both classical and molecular approaches. Methods of molecular karyology will be applied for the first time in this cestodes group. Fluorescence in situ hybridization enables detection of number and location of ribosomal genes as well as genes for histones H3 and H4. The key outputs arising from this project will be new description and re-description of karyotypes, and detailed molecular cytogenetic analysis of chromosomes. The newly obtained complex cytogenetic data will be, in combination with new molecular and morphological data, used for the revision of phylogenetic relationships between tapeworms of the genus Diphyllobothrium as well as at the level of the family Diphyllobothriidae.
Duration: 1.1.2018 - 31.12.2021
Comparative cytogenetic analysis of the thorny-headed worm Acanthocephalus lucii from the industrially polluted area of Zemplín Region and the natural volcanic lake Morské Oko.
Komparatívna cytogenetická analýza háčikohlavca Acanthocephalus lucii z priemyselne znečistenej oblasti Zemplína a prírodného sopečného jazera Morské Oko.
Program: Inter-academic agreement
Project leader: RNDr. Orosová Martina PhD.
Annotation:The project aims to study chromosomes of Acanthocephalus lucii (Acanthocephala: Echinorhynchidae) from two selected research areas where one is exposed to severe mixed industrial pollution (Zemplínska Šírava water reservoir) and the other (Morské Oko) is relatively free of pollution. The detailed structure of the karyotype and individual chromosomes of A. lucii will be characterized by standard and molecular techniques of karyology. For the first time, a new methodological approach will be applied to identify and characterize repetitive DNA elements in the genome of this species (RepeatExplorer) in order to obtain suitable chromosomal markers. We expect that FISH mapping using these markers in ecologically distinct populations of A. lucii will provide original data that will allow answers to questions regarding the likely impact of environment with a high degree of anthropogenic pollution on chromosomes of the fish parasite studied.
Duration: 1.1.2021 - 31.12.2022
Parasites in domestic and wild carnivores from Slovakia and Bulgaria in the era of global changes
Parazity domácich a voľne žijúcich mäsožravcov na Slovensku a v Bulharsku v období globálnych zmien
Program: Inter-academic agreement
Project leader: doc. MVDr. Hurníková Zuzana PhD.
Annotation:Free living carnivores are involved in maintenance and spread of several viral, bacterial and parasitic zoonotic diseases; potentially transmissible to domestic, farm and game animals, and also to humans. The project is focused at comparison of the parasite fauna composition of domestic and free living carnivores in both Bulgaria and Slovakia including parasitic agents transmissible to man. The occurrence of parasites in ecologically different areas will be collated and the host-parasite-landscape interactions studied. Molecular characteristic of parasite strains as well as the homology of isolates obtained in selected areas will provide the basis for evaluation of possible spread of parasites from south (Bulgaria) northward (Slovakia. The risk factors that advance the parasite circulation and risk areas of increased appearance of reservoirs, vectors and potential hosts with respect to spread of parasitic infections will be identified.
Duration: 1.1.2018 - 31.12.2021
Transmission patterns and genetic polymorphisms of zoonotic Echinococcus tapeworms in central Europe
Transmisné cykly a genetické polymorfizmy zoonóznych pásomníc rodu Echinococcus v strednej Európe
Program: Bilateral - other
Project leader: RNDr. Šnábel Viliam CSc.
Annotation:Alveolar echinococcosis is of increasing public health concern in central Europe, as human cases appear to be increasingly frequent. The impact of landscape, host animals and genetic variability of the parasite on infection risk and pathogenicity is not yet fully understood. A specific issue will be a survey of clade composition of Echinococcus multilocularis in selected European and Russian/Siberian areas that might contribute to better understanding of its evolutionary history and how the parasite spread worldwide. Cystic echinococcosis continues to be a frequent livestock disease in southern and eastern Europe. From gained data, more effective public health policies to reduce E. granulosus s.l. transmission will be implemented, also with regard to prevent precursors to regional and global expansions associated with trade.
Duration: 1.1.2019 - 31.12.2021
The place of carnivores in transmission diseases of zoonotic foci
Úloha mäsožravcov pri prenose chorôb v zoonotickom ložisku
Program: Inter-academic agreement
Project leader: RNDr. Víchová Bronislava PhD.
Duration: 1.1.2019 - 31.12.2021
Eggs ultrastructure of the basal tapeworm groups (Caryophyllidea, Diphyllobothriidea)
Ultraštruktúra vajíčok bazálnych skupín pásomníc (Caryophyllidea, Diphyllobothriidea)
Program: Inter-academic agreement
Project leader: RNDr. Bruňanská Magdaléna DrSc.
Duration: 1.1.2018 - 31.12.2021
Wild carnivores as a reservoir of zoonotic diseases in the north-eastern Poland
Voľne žijúce mäsožravce ako rezervoár zoonónych ochorení na území severovýchodného Poľska
Program: Inter-academic agreement
Project leader: MVDr. Dvorožňáková Emília PhD.
Annotation:Wild carnivores are an important reservoir for zoonotic diseases and play a significant role in their transmission to humans. The aim of the project is to study occurrence of such zoonotic diseases as: trichinellosis, echinococcosis, toxocarosis, babesiosis, anaplasmosis, mycoplasmosis, and borreliosis in wild carnivores inhabiting north-eastern Poland. Partially collected material and routinely used methods will provide reliable results. It will be the first complex study showing the species - specific pattern of carnivore hosts for zoonotic diseases in north-eastern Poland.
Duration: 1.1.2019 - 31.12.2022

The total number of projects: 9