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The effect of long-term exposure to a chemical mixture of pesticides, contaminants and food additives at low doses as an origin of neurodevelopmental disorders: an experimental real-life risk simulation approach

Pharmacology

RNDr. Mojmír Mach, PhD.

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Faculty of Pharmacy, Comenius University

In real life, mixtures of xenobiotics can lead to a 'cocktail' effect. Studies have shown that these mixtures can lead not only to predictable additive effects but also to unpredictable synergistic, or antagonistic effects. From early intrauterine life till elderly, the individual is continuously exposed to chemicals with beneficial or detrimental effects depending on the doses, windows of exposure and combinations. Many of these exposures are considered risk factors for many diseases. These observations indicate the necessity of using improved hazard-evaluation models, such as the real-life risk simulation (RLRS) scenario. PhD. study will focus on determining the rate of cumulative risk of a selected mixture of xenobiotics at low doses below the NOAEL (No-Observed-Adverse-Effect Level - dose value without an observed adverse effect). The experiments will mainly focus on developmental neurotoxicity and immunotoxicity in such affected individuals.