Electronic Library of Scientific Literature - © Academic Electronic Press


Volume 37 / No. 2 / 2003

Download full text in PDF format (640 kB)



Endocrine Regulations (since 1967 to 1990 Endocrinologia Experimentalis) is an international journal on experimental and clinical endocrinology edited quarterly in English by care of the Institute of Experimental Endocrinology, Slovak Academy of Sciences (Bratislava, Slovakia) and published by the Slovak Academic Press (Bratislava, Slovakia).

This journal aims to publish original manuscripts or minireviews on experimental and clinical endocrinology and diabetes.

The submission of a manuscript to Endocrine Regulations implies that it has not been previously published or is not being submitted for publication elsewhere and that the manuscript has been approved by all authors who are ready to take public responsibility for the content.

All materials relating to human investigation will be published upon the understanding that design of the work has been approved by the local Ethical Committee or that it conforms to ethical guidelines of the Declaration of Helsinki. The animal experiments should state the conformance to guidelines on animal care.


Manuscripts in triplicate with three sets of illustrations (of which one is an original) should be sent to:

Richard Kvetnansky, Ph.D., Dr.Sc., Chief Editor,

Institute of Experimental Endocrinology,

Vlárska 3, 833 06 Bratislava, Slovakia

All text must be printed on one side of the sheet only with appropriate margins and double spacing to give adequate space for editorial notes. The corresponding author should indicate his/her full mailing address including phone and fax numbers and the e-mail address.

Manuscripts on disc. The submissions of manuscripts prepared on 3.5 inch discs on IBM compatible computers is encouraged, the preferred word processors being Microsoft Word. However, also in this case the disc must be accompanied by three hard copies of the manuscript. The disk should be labelled by the name of the first author, type of word processor, its version and file name and must also accompany the final version of the manuscript.

Types of manuscripts. Standard original papers should contain following sections: * Title, * Abstract (divided into sections Objective, Methods, Results, Conclusions), * Key Words, * Introduction, * Materials and Methods (in clinical papers this section should read * Subjects and Methods), * Results, * Discussion, (* Acknowledgements), * References. There is no length limit for these papers.

Minireviews should give an overview of a defined field preferably of author,s own professional interest and experience. They should not exceed 25 typed pages including complete References and should usually contain * Abstract, * Key Words, * Individual sections and subsections, * References.


Title page should give * the title of the article (main key words should be preferably included into the title to give sufficient information to allow the reader to judge the relevance of a paper to his field), * full names of authors, * institute of origin, * short title (running head), * name and full address of corresponding author including phone and fax numbers and e-mail naddress as well.

Abstract should clearly indicate the purpose of the study (Objective), basic procedures (Methods), main findings (Results) and principal conclusions (Conclusions). New and original findings should be emphasized, clearly defined and defended. The abstract must be easily understood indepenently of the full text of the paper

Key Words. Up to 8 key words (in exceptional cases even more) should be carefully selected to give appropriate information to the users of international information networks.

Introduction should give a brief overview of background informations and clearly define the purpose of the study...

Materials and Methods (in clinical manuscripts Subjects and Methods) should give full informations sufficient to allow others to repeat the work. It is recommended to divide it into subsections. Established and routine methods (if not considerably modified) should be just cited by the appropriate references, the modifications being briefly but clearly described. Statistical methods should be clearly described.

Results should describe concisely and clearly the results in logical sequence. Any interpretations should be avoided and definitely shifted to the Discussion. Do not repeat Materials and Methods, and do not repeat the data presented in tables and figures.

Discussion. Do not simply repeat the data presented in Introduction and Results section. Define and emphasize the new and important aspects of the study and the conclusions that follow. Relate results to other relevant studies, interpret them and explain the differences, if any. Working hypotheses and theories may be briefly outlined.

Acknowledgements. This short section, if necessary, contains acknowledgements of personal and/or financial assistance.

References. Begin this section on a new page. References should be assembled in alphabetical order according to the first author. More than one paper from the same author(s) in the same year must be identified by the letters a, b, c etc. placed after the year of publication. All listed references must be cited in the text by the first author et al. and the year (in a case of two authors only cite both). Following possibilities are recommended: (1) Brown and White (1993) found that ...; (2) ... as observed by Black et al. (1992); (3) ... as previously reported by several authors (Black et al. 1992; Brown and White 1993; Green et al. 1995).

The names of authors in the text and in references should be typed in small letters and underlined (e.g. White and Brown). The volume should be typed in bold.

The style for the list of references is as follows:

A.Journal Articles:

Itoh M, Okugawa T, Shiratori N, Ohashi H: Treatment with triiodothyronine (T3) against multinodular goiter fails to prevent the onset of Graves disease. Endocrine Regul 29, 151-156, 1995

B. Book Chapters:

Mornex R, Orgiazzi JJ: Hyperthyroidism. In: The Thyroid Gland (Ed. M de Visscher), pp. 279-362, Raven Press, New York 1980

C. Books:

Podoba J: Endemic goiter in Slovakia. VEDA, Bratislava, 1962

The statement “in press” may be used only for a paper accepted for publication in the indicated journal. Unpublished data or Personal communication may be used in the text, but must not be listed in References.

Tables should be constructed as simply as possible, typed on separate sheets and numbered consecutively with Arabic numeral. There should be a short and descriptive heading and appropriate footnotes. Not more than 4 vertical rows should be used in a table planned to occupy one column and not more than 8-10 rows for that designed for two columns of a page.

Figures should be prepared in proportional way with lettering of appropriate size in order to permit such reduction in size to occupy either one or two columns on the page. Drawings (graphs, charts, diagrams etc.) should be submitted either as original or camera ready glossy photographs. Computer generated graphs must be printed by high quality laser printers on high quality camera ready paper. High quality photographs should be submitted on glossy paper.

Units of Measurement. Results should be expressed in SI units.

Abbreviations. Non-standard abbreviations should be properly defined in the text the first time they are used.


There are no page charges. Reprints order forms are sent to the corresponding author together with galley proofs. Color illustrations may be published for extra charges.


E. Ronald de Kloet

Division of Medical Pharmacology, LACDR/LUMC, Leiden University, 2300 RA Leiden, The Netherlands
E-mail: e.kloet@lacdr.leidenuniv.nl

Abstract. The stress system orchestrates body and brain responses to the environment. This action exerted by the mediators of the stress system has two modes of operation. The immediate response mode driven by corticotropin-releasing hormone (CRH) organises via CRH-1 receptors the behavioural, sympathetic and hypothalamic-pituitary-adrenal (HPA) responses to a stressor. In the other - slower - mode, which facilitates behavioural adaptation, the urocortins acting through CRH-2 receptors seem prominent. Corticosteroid hormones secreted by the adrenal cortex are implicated in both modes through their high affinity type 1 (mineralocorticoid receptors - MR) and lower affinity type 2 (glucocorticoid receptors - GR) receptors that are co-localised in limbic neural circuitry. Current data suggest that MR controls in specific afferents the threshold or sensitivity of the fast CRH-1 driven stress system mode and thus prevents disturbance of homeostasis, while GR facilitates its recovery by restraining in these very same circuits stress responses and by mobilising energy resources. In preparation for future events GR facilitates behavioural adaptation and promotes storage of energy. The balance in the two stress system modes is thought to be essential for cell homeostasis, mental performance and health. Imbalance induced by genetic modification or chronic stressors changes specific neural signalling pathways underlying psychic domains of cognition and emotion, anxiety and aggression. This Yin-Yang stress concept is fundamental for genomic strategies to understand the mechanistic underpinning of cortisol-induced stress-related disorders such as i.e. severe forms of depression and co-morbid diseases.
Stress – Behaviour – Corticosteroids – Brain - Genes

ENDOCRINE REGULATIONS, Vol. 37, 51–68, 2003

Download full text in PDF format (303 kB)

Catecholamines and stress

David S. Goldstein

Download full text in PDF format (114 kB)



Download full text in PDF format (314 kB)

Electronic Library of Scientific Literature - © Academic Electronic Press