Odbor medzinárodnej spolupráce informuje

CALL OPEN - Pre-clinical Research to Develop Effective Therapies for Rare Diseases

Vložil(a): Z. Černáková, 19.12.2019, videné 182-krát

 

Consortium EJP RD (European Joint Programme on Rare Diseases) has launched 2nd Joint Transnational Call for Rare Diseases Research Projects (JTC 2020) on

 

"PRE-CLINICAL RESEARCH TO DEVELOP EFFECTIVE THERAPIES FOR RARE DISEASES”

 

A number of national and regional funding organisations including the Slovak Academy of Sciences will participate in the EJP RD Joint Transnational Call (JTC) 2020 and will fund multilateral research projects on rare diseases together with the European Commission (EC) under the EJP-COFUND action.

The deadline for registration and submission of pre-proposals is 18th February 2020.

 

1. AIM OF THE CALL

 

The aim of the call is to enable scientists in different countries to build an effective collaboration on a common interdisciplinary research project based on complementarities and sharing of expertise, with a clear future benefit for patients.

 

Topic: PRE-CLINICAL RESEARCH TO DEVELOP EFFECTIVE THERAPIES FOR RARE DISEASES

Research proposals must cover at least one of the following areas:

  1. Development of novel therapies in a preclinical setting (including small molecules, repurposing drugs, cell and gene advanced therapies) focusing on condition(s) with unmet medical needs
  2. Use of disease models suitable for medicinal product’s development according to EMA guidelines
  3. Development of predictive and pharmacodynamics (PD) biomarkers (with appropriate analytical methods e.g. OMICS) in a preclinical setting (e.g. in the validated model or in pre-collected human samples) for monitoring the efficiency of the therapy. The model chosen must mimic the human diseases and be transposable so that the biomarker identified in animals can be valid for humans
  4. Proof of principle studies fostering an early (pre-clinical) stage of drug development (excluding interventional clinical trials of phase 1-4).

 

The following approaches and topics are excluded from the scope of the call:

  1. Therapeutic approaches concerning rare infectious diseases, rare cancers and rare adverse drug events in treatments of common diseases
  2. Interventional clinical trials
  3. Surgery or radiation therapies
  4. Studies that focus on research to accelerate diagnosis or to set up new registry/cohort studies to explore disease progression and mechanisms as these were the focus of JTC 2019.
  5. Rare neurodegenerative diseases which are within the main focus of the Joint Programming Initiative on Neurodegenerative Disease Research (JPND; http://www.neurodegenerationresearch.eu/). These are: Alzheimer’s disease and other dementias; Parkinson’s disease (PD) and PD-related disorders; Prion disease; Motor Neuron Diseases; Huntington’s disease; Spinal Muscular Atrophy and dominant forms of Spinocerebellar Ataxia.  Interested researchers should refer to the relevant JPND calls.
    Childhood dementias/neurodegenerative diseases are not excluded.

 

2. CALL TIMELINE

18th February 2020

Pre-proposal submission deadline

End of April 2020

Invitation to full proposal

16th June 2020

Full proposal submission deadline

28th July 2020

Deadline for rebuttals

November 2020

Notification of funding decision

 

Indikatívny rozpočet pre výskumné tímy zo SAV: 120 000 €/projekt/3 roky (z toho spoluúčasť ústavu SAV vo výške 45 000 €)

Bližšie informácie sú dostupné v prílohe a na stránke konzorcia: http://www.ejprarediseases.org/index.php/open-call-jtc2020/

Uchádzači môžu na vyhľadávanie partnerov využiť nástroj "Looking for collaborations" na stránke ERA-NET ERARE.

 

Kontaktná osoba: Zuzana Černáková, +421 2 57510118, cernakova@up.upsav.sk