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Genetic aspects of vitamin D receptor and metabolism in relation to the risk of multiple sclerosis

In: General Physiology and Biophysics, vol. 32, no. 4
Lucia Krizova - Branislav Kollar - Daniela Jezova - Peter Turčáni
Detaily:
Rok, strany: 2013, 459 - 466
O článku:
Recent findings suggest that polymorphisms in vitamin D pathway genes are candidates for association with multiple sclerosis susceptibility. It has been now well demonstrated that vitamin D has immunomodulatory functions that may be favorable for reduction of multiple sclerosis risk. Current research has been focused on identification of new variants of genes involved in vitamin D pathway, namely in vitamin D receptor and enzymes of vitamin D metabolism. These variants have been intensively studied as possible genetic predictors of both vitamin D levels and the risk of multiple sclerosis. Considering the findings available up-to-date, we may recognize two groups of genetic variants. The first group of genes was found to predict vitamin D levels but not the risk of multiple sclerosis. The second group of genetic variants is represented by promising genes predicting vitamin D levels as well as the risk of multiple sclerosis. A strong association with increased risk of the disease has been observed for a rare variant in the CYP27B1 gene encoding a vitamin D-activating enzyme. Observed interaction between genetic and epidemiological findings brings the rationale for supplementation trials of vitamin D. Although promising effects of vitamin D supplementation have emerged, the results obtained so far are inconclusive and the real therapeutic significance of vitamin D supplementation remains to be elucidated.
Ako citovať:
ISO 690:
Krizova, L., Kollar, B., Jezova, D., Turčáni, P. 2013. Genetic aspects of vitamin D receptor and metabolism in relation to the risk of multiple sclerosis. In General Physiology and Biophysics, vol. 32, no.4, pp. 459-466. 0231-5882.

APA:
Krizova, L., Kollar, B., Jezova, D., Turčáni, P. (2013). Genetic aspects of vitamin D receptor and metabolism in relation to the risk of multiple sclerosis. General Physiology and Biophysics, 32(4), 459-466. 0231-5882.