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Prognostic implication of TIM-3 in clear cell renal cell carcinoma

In: NEOPLASMA, vol. 61, no. 1
J. Yuan - B. Jiang - H. Zhao - Q. Huang
Detaily:
Rok, strany: 2014, 35 - 40
O článku:
Clear cell renal carcinoma (ccRCC) is the most common tumor of the kidney.in adults. The prognosis of ccRCC remains unsatisfactory. Recently, T cell immunoglobulin mucin-3 (TIM-3), a novel transmembrane protein, has been implicated in tumor biology. Its role in ccRCC remains unkonwn. The aim of this study was to investigate the roles of TIM-3 as a prognostic marker in patients with ccRCC.TIM-3 protein expression was determined by immunohistochemistry and Western blot from 137 ccRCC tumor samples and adjacent normal renal tissues. We performed also the cell proliferation assay using 3-(4,5-dimethylthiazol -2yl)-2,5-diphenyl-2H tetrazolium bromide (MTT) and cell invasion assay. The effects of small interfering RNA (siRNA)-mediated knockdown of TIM-3 (TIM-3 siRNA) in two human ccRCC cell lines were evaluated. TIM-3 expression was higher in ccRCC tissue than in the adjacent normal renal tissue (P<0.001). High TIM-3 expression was an independent predictor of both cancer-specific survival and progression-free survival. TIM-3 protein was expressed in both ccRCC cell lines. Knockdown of TIM-3 suppressed the proliferation and invasion capacity of ccRCC cell lines.TIM-3 expression was associated with poor prognosis in ccRCC. Taken together, TIM-3 is a potential prognostic marker in ccRCC. Keywords: TIM-3; clear cell renal cell carcinoma; prognosis; marker
Ako citovať:
ISO 690:
Yuan, J., Jiang, B., Zhao, H., Huang, Q. 2014. Prognostic implication of TIM-3 in clear cell renal cell carcinoma. In NEOPLASMA, vol. 61, no.1, pp. 35-40. 0028-2685.

APA:
Yuan, J., Jiang, B., Zhao, H., Huang, Q. (2014). Prognostic implication of TIM-3 in clear cell renal cell carcinoma. NEOPLASMA, 61(1), 35-40. 0028-2685.