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Mesenchymal stem cells in prostate cancer have higher expressions of SDF-1, CXCR4 and VEGF

In: General Physiology and Biophysics, vol. 32, no. 2
Guanxiong Ding - Lujia Wang - Hua Xu - Zheng Xu - Chenchen Feng - Qiang Ding - Zujun Fang - Zhong Wu - Haowen Jiang - Jianfeng Xu - Peng Gao
Detaily:
Rok, strany: 2013, 245 - 250
O článku:
Our previous study found that the activity of PCa-MSCs, which could stimulate the cell proliferation of RM-1, was significantly different compared to BMMSCs. Our results indicated that it could be mediated in part by growth factors/chemokines, which were involved in the different activity between two kinds of MSCs (PCa-MSCs and BMMSCs). Normal MSCs (BMMSCs) were isolated from the femur, tibia of the normal mice; prostate tumor MSCs (PCa-MSCs) were obtained from the mice implanted with prostate tumor. Analysis of the expression of SDF-1, CXCR4, VEGF、bFGF and vWF of two kinds of MSCs were examined by ELISA, Realtime-PCR and Western blotting. The expressions of SDF-1 and CXCR4 in PCa-MSCs were higher compared to BMMSCs. Expressions of bFGF and vWF were higher in PCa-MSCs yet the difference did not reach statistical significance. The expression of VEGF was significantly higher in PCa-MSCs. Our data showed that activity of PCa-MSCs was significantly improved compared with BMMSCs, which seemed to have an intrinsic, cell-specific capacity localized to PCa. It could be induced by some factors or chemokines such as SDF-1, CXCR4, and VEGF. The possible role of PCa-MSCs in the process of PCa development needed further clarification.
Ako citovať:
ISO 690:
Ding, G., Wang, L., Xu, H., Xu, Z., Feng, C., Ding, Q., Fang, Z., Wu, Z., Jiang, H., Xu, J., Gao, P. 2013. Mesenchymal stem cells in prostate cancer have higher expressions of SDF-1, CXCR4 and VEGF. In General Physiology and Biophysics, vol. 32, no.2, pp. 245-250. 0231-5882.

APA:
Ding, G., Wang, L., Xu, H., Xu, Z., Feng, C., Ding, Q., Fang, Z., Wu, Z., Jiang, H., Xu, J., Gao, P. (2013). Mesenchymal stem cells in prostate cancer have higher expressions of SDF-1, CXCR4 and VEGF. General Physiology and Biophysics, 32(2), 245-250. 0231-5882.