In: General Physiology and Biophysics, vol. 24, no. 1
Z Fišar - M Anders - L Kališová
Detaily:
Rok, strany: 2005, 113 - 128
O článku:
We tested a hypothesis that a long-term administration of antidepressants acting through different primary biochemical mechanisms is associated with changes in the platelet serotonin (5-hydroxytryptamine, 5-HT) transport. Laboratory rats were administered norepinephrine reuptake inhibitors (desipramine, maprotiline), selective 5-HT reuptake inhibitor (citalopram), reversible monoamine oxidase inhibitor (moclobemide), and lithium (inositol monophosphatase inhibitor among others) during a 4-week period. Apparent kinetic parameters of platelet 5-HT transport were analyzed. Significant decrease in apparent Michaelis constant (KM ) was found after the administration of all tested antidepressants except for desipramine. There was certain increase in maximal velocity (Vmax ) values following the administration of desipramine, maprotiline, and citalopram; however, the all Vmax changes were not significant. Vmax /KM ratio representing limiting permeability at low extracellular concentrations of 5-HT was systematically increased in all the tested drugs, but significant changes were occurred only in maprotiline- and citalopram-treated rats. Adaptive changes in platelet 5-HT transport induced by citalopram were opposite to the acute inhibitory effect of this drug on 5-HT transporter activity. An increase in limiting membrane permeability for 5-HT could be included in the common adaptive effect of the long-term administration of antidepressants that differ in pharmacologic selectivity.
Ako citovať:
ISO 690:
Fišar, Z., Anders, M., Kališová, L. 2005. Effect of pharmacologically selective antidepressants on serotonin uptake in rat platelets. In General Physiology and Biophysics, vol. 24, no.1, pp. 113-128. 0231-5882.
APA:
Fišar, Z., Anders, M., Kališová, L. (2005). Effect of pharmacologically selective antidepressants on serotonin uptake in rat platelets. General Physiology and Biophysics, 24(1), 113-128. 0231-5882.