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Ghrelin suppression of potassium currents in smooth muscle cells of human mesenteric artery

In: General Physiology and Biophysics, vol. 25, no. 3
M Mladenov - K Hristov - D Duridanova
Detaily:
Rok, strany: 2006, 333 - 338
O článku:
Ghrelin is a 28-amino acid peptide hormone which modulates many physiological functions including cardiovascular homeostasis. Here we report some novel findings about the action of ghrelin on smooth muscle cells (SMC) freshly isolated from human mesenteric arteries. Ghrelin (10-7 mol/l) significantly suppressed the iberiotoxin-blockable component of potassium currents (IK) and depolarized the cell membrane, while having no effect on Ca2+ currents. Inhibition of inositol-trisphosphate (IP3)-activated Ca2+ release channels, depletion of sarcoplasmic reticulum (SR) Ca2+ stores, blockade of phospholipase D (PLD) or protein kinase C (PKC) each abolished the effect of ghrelin on IK, while the inhibition of phospholipase C (PLC) did not. These data imply that in human mesenteric artery SMC ghrelin suppresses IK via PLD, PKC and SR Ca2+-dependent signaling pathway.
Ako citovať:
ISO 690:
Mladenov, M., Hristov, K., Duridanova, D. 2006. Ghrelin suppression of potassium currents in smooth muscle cells of human mesenteric artery. In General Physiology and Biophysics, vol. 25, no.3, pp. 333-338. 0231-5882.

APA:
Mladenov, M., Hristov, K., Duridanova, D. (2006). Ghrelin suppression of potassium currents in smooth muscle cells of human mesenteric artery. General Physiology and Biophysics, 25(3), 333-338. 0231-5882.