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Tetraphenylphosphonium-selective electrode as a tool for evaluating mitochondrial permeability transition pore function in isolated rat hepatocytes

In: General Physiology and Biophysics, vol. 25, no. 3
A Lábajová - J Kofránek - P Křiváková - Z Červinková - Z Drahota
Detaily:
Rok, strany: 2006, 325 - 331
O článku:
The changes in mitochondrial membrane potential (Δψm) were used as an indicator for evaluating the mitochondrial permeability transition pore (MPTP) function. We found that in situ mitochondria in digitonin-permeabilized hepatocytes were coupled and responded to the addition of substrates, inhibitors and uncouplers. Ca2+-induced Δψm dissipation was caused by MPTP opening because this process was inhibited by cyclosporin A. MPTP opening was enhanced by the pro-oxidant tert-butyl hydroperoxide.
Ako citovať:
ISO 690:
Lábajová, A., Kofránek, J., Křiváková, P., Červinková, Z., Drahota, Z. 2006. Tetraphenylphosphonium-selective electrode as a tool for evaluating mitochondrial permeability transition pore function in isolated rat hepatocytes. In General Physiology and Biophysics, vol. 25, no.3, pp. 325-331. 0231-5882.

APA:
Lábajová, A., Kofránek, J., Křiváková, P., Červinková, Z., Drahota, Z. (2006). Tetraphenylphosphonium-selective electrode as a tool for evaluating mitochondrial permeability transition pore function in isolated rat hepatocytes. General Physiology and Biophysics, 25(3), 325-331. 0231-5882.