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Effect of peroxisome proliferator-activated receptor α ligand fenofibrate on Kv channels in the insulin-secreting cell line HIT-T15

K Shimomura - M Ikeda - Y Ariyama - P Proks - Y Shimomura - M Mori - S Matsumoto

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Rok, strany / Year, pages: 2006, 455-460

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Publikované / Published: 0000-00-00

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Ligands for peroxisome proliferator-activated receptors α (PPARα) are clinically used for the treatment of patients with hyperlipidemia. As we have previously shown, a synthetic ligand of PPARα, fenofibrate, has a stimulatory effect on insulin secretion in clonal hamster insulinoma β-cell line HIT-T15 cells. We have also demonstrated that fenofibrate directly inhibits ATP-sensitive potassium (KATP) channels, an effect independent of PPARα. In this study, fenofibrate was shown to be able to reduce voltage-dependent K+ (Kv) channel currents in voltage-independent manner. Therefore, fenofibrate may modulate insulin secretion not only via inhibition of KATP channels but also via reduction of the Kv channel current.

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