T-type calcium channel blockers – new and notable

In: General Physiology and Biophysics, vol. 30, no. 4

Ľubica Lacinová

Detaily:

Rok, strany: 2011, 403 - 409

O článku:

Since cloning of the T-type or CaV3.n calcium channel family in 1998–1999 much progress was made in investigation of their regulation. Most effective metal CaV3 channel blockers are trivalent cations from lanthanide group together with transition metals La3+ and Y3+. Divalent cations Zn2+, Cu2+ and Ni2+ inhibit CaV3.2 channels more efficiently than CaV3.1 and CaV3.3 channels via second high-affinity binding site including histidine H191 specific for the CaV3.2 channel. Dihydropyridines and phenylalkylamines in addition to block of L-type calcium channel can inhibit CaV3 channels in clinically relevant concentration.

Ako citovať:

ISO 690:

Lacinová, Ľ. 2011. T-type calcium channel blockers – new and notable. In General Physiology and Biophysics, vol. 30, no.4, pp. 403-409. 0231-5882.

APA:

Lacinová, Ľ. (2011). T-type calcium channel blockers – new and notable. General Physiology and Biophysics, 30(4), 403-409. 0231-5882.