Pharmacological studies of Cav3.1 T-type calcium channels using automated patch-clamp techniques

In: General Physiology and Biophysics, vol. 30, no. 1

Kee Choi - Chiman Song - Chan Cheong - Hyewhon Rhim

Detaily:

Rok, strany: 2011, 100 - 105

O článku:

T-type calcium channels are involved in a variety of physiological and pathophysiological processes, and thus could be therapeutic targets. However, there is no T-type channel selective blocker for use in clinical practice, demanding a need for the development of novel drugs where a higher-throughput screening system is required. Here we present pharmacological studies on Cav3.1 T-type channels using automated patch-clamp. The IC50 values obtained from automated patch-clamp and conventional one showed a good correlation (correlation coefficient of 0.82), suggesting that the automated patch-clamp is an efficient and reliable method for ranking the drug potencies for T-type channels.

Ako citovať:

ISO 690:

Choi, K., Song, C., Cheong, C., Rhim, H. 2011. Pharmacological studies of Cav3.1 T-type calcium channels using automated patch-clamp techniques. In General Physiology and Biophysics, vol. 30, no.1, pp. 100-105. 0231-5882.

APA:

Choi, K., Song, C., Cheong, C., Rhim, H. (2011). Pharmacological studies of Cav3.1 T-type calcium channels using automated patch-clamp techniques. General Physiology and Biophysics, 30(1), 100-105. 0231-5882.