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Contribution of Nav1.1 to cellular synchronization and automaticity in spontaneous beating cultured neonatal rat ventricular cells

In: General Physiology and Biophysics, vol. 30, no. 1
Haruko Masumiya
Detaily:
Rok, strany: 2011, 28 - 33
O článku:
Two factors of cell coupling influence cellular synchronization and automaticity: gap junction coupling and ion channels activity. However, the role of Na+ channel isoforms underlying cell-to-cell interaction and cellular automaticity is not well understood. To address these questions, we studied mRNA expression of Na+ channel isoforms and the effects of TTX on spontaneously beating cultured ventricle cells. Using RT-PCR technique we demonstrated the presence of Nav1.1 and Nav1.5 channels. The reduction of Nav1.1 channel activity disturbed cell-to-cell interaction and changed beating rates. Thus, Nav1.1 channel is involved in cellular synchronization and automaticity.
Ako citovať:
ISO 690:
Masumiya, H. 2011. Contribution of Nav1.1 to cellular synchronization and automaticity in spontaneous beating cultured neonatal rat ventricular cells. In General Physiology and Biophysics, vol. 30, no.1, pp. 28-33. 0231-5882.

APA:
Masumiya, H. (2011). Contribution of Nav1.1 to cellular synchronization and automaticity in spontaneous beating cultured neonatal rat ventricular cells. General Physiology and Biophysics, 30(1), 28-33. 0231-5882.