Scaling law: A global topological property of genetic sequences

Rok, strany: 2012, 221 - 224

Here, we study the topological properties of genetic sequence by viewing the entire sequence as a whole. First, a systematic way of coding the gene-combinations in a genetic sequence is developed. Next, we apply the coding method to real genetic sequences, and find a scale-free power-law distribution for some particular kinds of gene-combinations. Furthermore, we also present a model to reproduce the observed scale-free feature, which is based on three generic mechanisms: 1) Growth mechanism – genetic sequences expands continuously by the addition of new codon; 2) Preferential replication mechanism – the newly added codon at every time step is a replication of one of existed condons, and the probability that a codon is replicated is proportional to its emerging times in existed sequence; and 3) Mutation mechanism – following (2) the newly added codon has a small probability to mutate. To our knowledge, no report has been published to study the genetic sequences in such way.

ISO 690:

Bu, S. 2012. Scaling law: A global topological property of genetic sequences. In General Physiology and Biophysics, vol. 31, no.2, pp. 221-224. 0231-5882.

APA:

Bu, S. (2012). Scaling law: A global topological property of genetic sequences. General Physiology and Biophysics, 31(2), 221-224. 0231-5882.