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Estimation of rate constants of drug binding to open channels of cardiac transient outward current

In: General Physiology and Biophysics, vol. 31, no. 1
Jiří Šimurda - Milena Šimurdová
Detaily:
Rok, strany: 2012, 113 - 116
O článku:
An improved approach to the evaluation of the rate constants of drugs binding to the open channel underlying the transient outward potassium current It0 is described. It is based on an analysis of a quantitative model formulated by a set of twelve differential equations. The rate constants are calculated from the time constants resulting from an approximation of the time course of apparent inactivation of the recorded It0 by two exponentials in the absence and by three exponentials in the presence of a blocking agent. The model study confirmed significantly higher accuracy in comparison with the existing electrophysiological method.
Ako citovať:
ISO 690:
Šimurda, J., Šimurdová, M. 2012. Estimation of rate constants of drug binding to open channels of cardiac transient outward current. In General Physiology and Biophysics, vol. 31, no.1, pp. 113-116. 0231-5882.

APA:
Šimurda, J., Šimurdová, M. (2012). Estimation of rate constants of drug binding to open channels of cardiac transient outward current. General Physiology and Biophysics, 31(1), 113-116. 0231-5882.