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Overexpression of platelet-derived growth factor-B increases the growth, invasion, and angiogenesis of gastric carcinoma cells through protein kinase B

In: NEOPLASMA, vol. 60, no. 6
Y. Guo - J. Yin - Z. Wang - L. Zha
Detaily:
Rok, strany: 2013, 605 - 613
O článku:
Platelet-derived growth factor-B (PDGF-B) promotes tumor metastasis by inducing tumor cell growth, invasion, and angiogenesis in several cancers. However, the roles of PDGF-B in gastric carcinoma are largely unknown. We established two gastric carcinoma cell lines, SGC7901 and BGC823, to stably overexpress PDGF-B by lentiviral vectors, and determined their growth, invasion and angiogenesis. Overexpression of PDGF-B significantly enhanced the cell proliferation, invasion and angiogenesis of both SGC7901 and BGC823 cells, accompanied with increased activation of AKT, which is a downstream target of PDGF signaling pathway. Consequently, an AKT kinase inhibitor abolished the PDGF-B overexpression-mediated up-regulation of growth, invasion and angiogenesis. These results indicate that PDGF-B signaling may promote the metastasis of gastric carcinoma through AKT signaling. Targeting the PDGF-B pathway may be an alternative strategy for the development of therapies for gastric cancers. Keywords: platelet-derived growth factor B (PDGF-B), gastric carcinoma, cell growth, invasion, angiogenesis, AKT
Ako citovať:
ISO 690:
Guo, Y., Yin, J., Wang, Z., Zha, L. 2013. Overexpression of platelet-derived growth factor-B increases the growth, invasion, and angiogenesis of gastric carcinoma cells through protein kinase B. In NEOPLASMA, vol. 60, no.6, pp. 605-613. 0028-2685.

APA:
Guo, Y., Yin, J., Wang, Z., Zha, L. (2013). Overexpression of platelet-derived growth factor-B increases the growth, invasion, and angiogenesis of gastric carcinoma cells through protein kinase B. NEOPLASMA, 60(6), 605-613. 0028-2685.