Clinicopathological and Prognostic Significance of α5β1-integrin and MMP-14 Expressions in Colorectal Cancer

Rok, strany: 2013, 254 - 261

The purpose of this study was to evaluate the association of expression level of α5β1-integrin and MMP-14 with clinicopathologic features and prognosis in colorectal cancer (CRC). The expressions of α5β1-integrin and MMP-14 in normal colorectal mucosa and CRC tissue were detected with immunohistochemistry. We estimated the five-year survival rate by the Kaplan-Meier method. The positive expressions rates of α5β1-integrin and MMP-14 in CRC tissue were 60.6% and 63.3% respectively, and there were significant differences on their positive expression rates between in CRC tissue and in normal colorectal mucosa(P<0.05). The expression rates of α5β1-integrin and MMP-14 in patients with poor histological differentiation, lymph node metastasis and high clinical staging were heightened. There was a significant difference (P<0.05) on the five-year survival rate for α5β1-integrin expression, which was 44.6% in positive groups and 75.5% in negative groups. And there was a significant difference (P<0.05) on the five-year survival rate for MMP-14 expression, which was 48.2% in positive group and 73.1% in negative group. The expression of α5β1-integrin and MMP-14 is correlated with the progression and metastasis of CRC, and α5β1-integrin and MMP-14 may be used as prognostic markers in CRC. Keywords: CRC, immunohistochemistry, α5β1-integrin, MMP-14, prognosis, survival

ISO 690:

Yang, B., Gao, J., Rao, Z., Shen, Q. 2013. Clinicopathological and Prognostic Significance of α5β1-integrin and MMP-14 Expressions in Colorectal Cancer. In NEOPLASMA, vol. 60, no.3, pp. 254-261. 0028-2685.

APA:

Yang, B., Gao, J., Rao, Z., Shen, Q. (2013). Clinicopathological and Prognostic Significance of α5β1-integrin and MMP-14 Expressions in Colorectal Cancer. NEOPLASMA, 60(3), 254-261. 0028-2685.