The relationship of multifocality and tumor burden with various tumor characteristics and survival in early breast cancer

Rok, strany: 2012, 566 - 573

The presence of multifocality and the aggregate tumor size were retrospectively analysed in a database of 1071 operated breast cancers. Around a quarter of all these cancers involved multiple foci, while a tenth of the total demonstrated more than one invasive focus. Although the multifocal cancers were smaller and more often screen-detected than the unifocal cancers, their aggregate tumor size was larger, and they more frequently displayed casting-type calcifications in the mammogram and HER2 positivity. Lobular histology favoured larger tumor burden. The invasive multifocal cancers were more commonly lymph node-positive than the other tumors. In a subgroup of 584 patients with a median follow-up time of 5 years, the larger size of the invasive tumor, the presence of LVI or lymph node involvement, HER2 positivity and triple negativity were associated with a poorer RFS and OS, while the outcome of screen-detected tumors was superior to that of non-screen-detected or interval cancers. A large tumor size, lymph node positivity and HER2 positive or triple negative phenotypes were independent determinants of a poorer survival rate. Keywords: breast cancer, multifocality, prognostic factor, tumor burden

ISO 690:

Kelemen, G., Farkas, V., Debrah, J., Ormandi, K., Voros, A., Kaizer, L., Varga, Z., Lazar, G., Kahan, Z. 2012. The relationship of multifocality and tumor burden with various tumor characteristics and survival in early breast cancer. In NEOPLASMA, vol. 59, no.5, pp. 566-573. 0028-2685.

APA:

Kelemen, G., Farkas, V., Debrah, J., Ormandi, K., Voros, A., Kaizer, L., Varga, Z., Lazar, G., Kahan, Z. (2012). The relationship of multifocality and tumor burden with various tumor characteristics and survival in early breast cancer. NEOPLASMA, 59(5), 566-573. 0028-2685.