In: NEOPLASMA, vol. 59, no. 4
P. Orendas - P. Kubatka - K. Kajo - N. Stollarova - M. Kassayova - B. Bojkova - M. Pec - V. Nosal - T. Kiskova - K. Zihlavnikova - R. Karsnakova
Detaily:
Rok, strany: 2012, 469 - 474
O článku:
The aim of this paper was to test lower, safe bexarotene dose administered alone and in combination with melatonin to improve its efficacy. Mammary carcinogenesis was induced by N-methyl-N-nitrosourea in female Sprague-Dawley rats, administered in two doses intraperitoneally between 42.-54. postnatal days and chemoprevention was initiated 7 days prior to first N-methyl-N-nitrosourea injection and lasted 15 weeks. Bexarotene, particularly in combination with melatonin decreased mammary tumor incidence and frequency with a shift from poorly to well differentiated carcinomas. Bexarotene alleviated glycaemia and liver/heart muscle glycogen concentration decreased as well as liver/thymus malondialdehyde increased in comparison with control group. The combination of bexarotene and melatonin is therefore beneficial in preventive-curative model of experimental mammary carcinogenesis and may be applied in oncological practice as such. Keywords: mammary carcinogenesis, female rats, bexarotene, melatonin, prevention
Ako citovať:
ISO 690:
Orendas, P., Kubatka, P., Kajo, K., Stollarova, N., Kassayova, M., Bojkova, B., Pec, M., Nosal, V., Kiskova, T., Zihlavnikova, K., Karsnakova, R. 2012. Melatonin enhanced bexarotene efficacy in experimental mammary carcinogenesis. In NEOPLASMA, vol. 59, no.4, pp. 469-474. 0028-2685.
APA:
Orendas, P., Kubatka, P., Kajo, K., Stollarova, N., Kassayova, M., Bojkova, B., Pec, M., Nosal, V., Kiskova, T., Zihlavnikova, K., Karsnakova, R. (2012). Melatonin enhanced bexarotene efficacy in experimental mammary carcinogenesis. NEOPLASMA, 59(4), 469-474. 0028-2685.