Perifosine downregulates MDR1 gene expression and reverses multidrug-resistant phenotype by inhibiting PI3K/Akt/NF-κB signaling pathway in a human breast cancer cell line

Rok, strany: 2012, 248 - 256

P-glycoprotein (P-gp)-mediated multidrug resistance (MDR) is the major clinical impediment to chemotherapy of breast cancers. Down-regulation of PI3K/Akt pathway has been described as related to reversal of MDR in cancer cells. Here, we investigated the reversal effect on MDR phenotype of perifosine, a new Akt inhibitor, in breast cancer cell lines. In this study, MCF-7/ADM cells and MCF-7 cells were treated with different concentrations of perifosine. Our results suggested that perifosine reversed MDR partially by downregulation of P-gp expression and inhibition of PI3K/Akt/NF-κB pathway in the MCF-7/ADM cell line. The novel Akt inhibitor perifosine may be a promising new drug due to its ability to reverse MDR in human breast cancer cells. Keywords: perifosine, PI3K/Akt, breast cancer, multidrug resistant gene 1, P-glycoprotein

ISO 690:

Lin, X., Zhang, X., Wang, Q., Li, J., Zhang, P., Zhao, M., Li, X. 2012. Perifosine downregulates MDR1 gene expression and reverses multidrug-resistant phenotype by inhibiting PI3K/Akt/NF-κB signaling pathway in a human breast cancer cell line. In NEOPLASMA, vol. 59, no.3, pp. 248-256. 0028-2685.

APA:

Lin, X., Zhang, X., Wang, Q., Li, J., Zhang, P., Zhao, M., Li, X. (2012). Perifosine downregulates MDR1 gene expression and reverses multidrug-resistant phenotype by inhibiting PI3K/Akt/NF-κB signaling pathway in a human breast cancer cell line. NEOPLASMA, 59(3), 248-256. 0028-2685.