Pretransplant serum ferritin level may be a predictive marker for outcomes in patients having undergone allogeneic hematopoietic stem cell transplantation

Rok, strany: 2012, 183 - 190

<p>Iron overload increases the risk of infections, veno-occlusive disease and hepatic dysfunction in post-transplant period. Our objective was to investigate the association of pre-transplant ferritin levels with complications and survival after allogeneic hematopoietic stem cell transplantation (alloHSCT).</p><p>We retrospectively analysed 84 patients’ data who had undergone allogeneic HSCT into two groups: patients with a serum ferritin level≥1000ng/ml, and patients with <1000 ng/ml at the time of HSCT.</p><p>Cox-regression analysis showed that pre-transplant serum ferritin levels were significantly higher in patients who had at least one infectious event compared with those who had no any infectious event in the post-transplant 100 days (p<0.023). </p><p>Overall survival (OS) and disease-free survival (DFS) rates were significantly higher in patients with a time-to-tx interval 12 months (p=0.002 and p=0.008 respectively). A higher risk of death was observed in high-ferritin group (hazard ratio=2.27, CI:1.01-5.09, p=0.023 for OS and hazard ratio=2.49, CI:1.12-5.53 p=0.039 for DFS). No significant effect on OS and DFS among groups was observed for variables conditioning regimen, gender and diagnosis. </p><p>Acute GVHD was more common in patients with a ferritin level ≥1000 ng /mL, but this was not statistically significant (p>0.05). </p><p>There was no statistical significance in both groups (ferritin≥1000ng /mL and ferritin0.05). Platelet and neutrophil engaftment day was not found statistically significant compared with both groups (p=0.273 and p=0.882, respectively).<br />Pre-transplant ferritin levels may predict poor outcomes in patients who had undergone allogeneic hematopoietic stem cell transplantation.</p> Keywords: allogeneic hematopoietic stem cell transplantation, ferritin, graft-versus-host disease, iron overload, survival

ISO 690:

Sivgin, S., Baldane, S., Kaynar, L., Kurnaz, F., Pala, C., Ozturk, A., Cetin, M., Unal, A., Eser, B. 2012. Pretransplant serum ferritin level may be a predictive marker for outcomes in patients having undergone allogeneic hematopoietic stem cell transplantation. In NEOPLASMA, vol. 59, no.2, pp. 183-190. 0028-2685.

APA:

Sivgin, S., Baldane, S., Kaynar, L., Kurnaz, F., Pala, C., Ozturk, A., Cetin, M., Unal, A., Eser, B. (2012). Pretransplant serum ferritin level may be a predictive marker for outcomes in patients having undergone allogeneic hematopoietic stem cell transplantation. NEOPLASMA, 59(2), 183-190. 0028-2685.