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Gemcitabine and Cisplatin Combination Chemotherapy in Triple Negative Metastatic Breast Cancer Previously Treated with a Taxane/Anthracycline Chemotherapy; Multicenter Experience

In: NEOPLASMA, vol. 59, no. 1
M Ozkan - V Berk - M Kaplan - M Benekli - U Coskun - A Bilici - M Gumus - N Alkis - F Dane - N Ozdemir - D Colak - M Dikilitas
Detaily:
Rok, strany: 2012, 38 - 42
O článku:
This study was aimed to establish clinical efficacy and tolerability of gemcitabine and cisplatin combination in patients with metastatic triple negative breast cancer progressing after anthracycline and taxane based chemotherapies.Thirty-three patients who were given cisplatin and gemcitabine for triple negative and metastatic breast cancer were evaluated retrospectively. A total of 141 cycles were administered with a median 4 cycles per patient. Median follow-up time was 14 months (range, 2–36 months). Objective response rate was 27.3%. Total clinical benefit of the combination was 48.4%. The estimated median progression free survival and median overall survival were 5 months and 14 months, respectively. The most common Grade 3 and 4 toxicity were neutropenia and thrombocytopenia observed in 10 (27.7%) and 9 (24.9%) patients, respectively. The combination of the gemcitabine and cisplatin after taxane/anthracycline is well tolerated and seems to be effective with acceptable toxicity profile. Keywords: Triple negative, metastatic breast cancer, cisplatin, gemcitabine
Ako citovať:
ISO 690:
Ozkan, M., Berk, V., Kaplan, M., Benekli, M., Coskun, U., Bilici, A., Gumus, M., Alkis, N., Dane, F., Ozdemir, N., Colak, D., Dikilitas, M. 2012. Gemcitabine and Cisplatin Combination Chemotherapy in Triple Negative Metastatic Breast Cancer Previously Treated with a Taxane/Anthracycline Chemotherapy; Multicenter Experience. In NEOPLASMA, vol. 59, no.1, pp. 38-42. 0028-2685.

APA:
Ozkan, M., Berk, V., Kaplan, M., Benekli, M., Coskun, U., Bilici, A., Gumus, M., Alkis, N., Dane, F., Ozdemir, N., Colak, D., Dikilitas, M. (2012). Gemcitabine and Cisplatin Combination Chemotherapy in Triple Negative Metastatic Breast Cancer Previously Treated with a Taxane/Anthracycline Chemotherapy; Multicenter Experience. NEOPLASMA, 59(1), 38-42. 0028-2685.