Clinical significance of the plasminogen activator system in relation to grade of tumor and treatment response in colorectal carcinoma patients

In: NEOPLASMA, vol. 58, no. 5

J Halamkova - I Kiss - Z Pavlovsky - J Tomasek - J Jarkovsky - Z Cech - S Tucek - L Hanakova - M Moulis - J Zavrelova - M Man - P Benda - O Robek - Z Kala - M Penka

Detaily:

Rok, strany: 2011, 377 - 385

O článku:

Urokinase (uPA) plays an essential role in the activation of plasminogen to plasmin, and together with its receptor (uPAR), tissue activator (tPA) and urokinase inhibitors (PAI 1, PAI 2, PAI 3 and protease nexin) forms the plasminogen activator system (PAS), a component of metastatic cascade importantly contributing to the invasive growth and angiogenesis of malignant tumours. In our project we examined the expression of uPA, uPAR, PAI 1 and PAI 2 in tumor tissue and we also studied the plasma levels of PAI 1 before and after the initiation of therapy in patients with colorectal carcinoma in relationship to grade of tumor and the treatment response. In our prospective evaluation we included 80 patients treated for adenocarcinoma of the colon and rectum. Analysis of collected data revealed statistically significant evidence of a relationship between the level of PAI 1 in plasma before treatment and grade of the tumor, which increases with tumor grade (p=0.025). We demonstrated that there exists a statistically significant relationship between the expression of PAI 2 (p Keywords: colorectal cancer, plasminogen activator system, grade, treatment response

Ako citovať:

ISO 690:

Halamkova, J., Kiss, I., Pavlovsky, Z., Tomasek, J., Jarkovsky, J., Cech, Z., Tucek, S., Hanakova, L., Moulis, M., Zavrelova, J., Man, M., Benda, P., Robek, O., Kala, Z., Penka, M. 2011. Clinical significance of the plasminogen activator system in relation to grade of tumor and treatment response in colorectal carcinoma patients. In NEOPLASMA, vol. 58, no.5, pp. 377-385. 0028-2685.

APA:

Halamkova, J., Kiss, I., Pavlovsky, Z., Tomasek, J., Jarkovsky, J., Cech, Z., Tucek, S., Hanakova, L., Moulis, M., Zavrelova, J., Man, M., Benda, P., Robek, O., Kala, Z., Penka, M. (2011). Clinical significance of the plasminogen activator system in relation to grade of tumor and treatment response in colorectal carcinoma patients. NEOPLASMA, 58(5), 377-385. 0028-2685.