In: NEOPLASMA, vol. 58, no. 5
A Chen - Y Shen - M Xia - L Xu - N Pan - Y Yin - F Miao - C Shen - W Xie - J Zhang
Detaily:
Rok, strany: 2011, 371 - 376
O článku:
HLA-G and HLA-E are nonclassical human MHC class I molecules, which promote tolerance to NK cytotoxicity. MICA and MICB are known to enhance the functions of NK and T cells. However, the expression of these molecules has never been investigated in liver cancer. <br />Using RT-PCR and western blot, we aimed to identify the expression of HLA-G, HLA-E, MICA and MICB in a panel of 41 tissues dissecting from liver cancer patients in China. <br />HLA-G mRNA was expressed in 8 of 41 Human Hepatocellular Carcinoma (HCC) specimens and in 1 adjacent normal hepatocellular tissue. The expression of HLA-G protein was found in 7 of the 8 HLA-G mRNA-positive HCC tissues. HLA-E mRNA was up-regulated in 56% HCC specimens but the expression of HLA-E protein was only upregulated in 29% HCC tissues in comparison with their adjacent normal counterpart. MICA and MICB mRNA was decreased in 5% and 8% HCC specimens, while the expression of their proteins decreased in 21% and 24% HCC tissues. <br />These results suggested that the expressions of HLA-G, HLA-E, MICA and MICB were differently up-regulated in HCC tissues. Furthermore, HLA-E and MICA/B genes showed obviously distinctive expression pattern at transcription and translation level. Keywords: Hepatocellular carcinoma; HLA-G; HLA-E; MICA; MICB
Ako citovať:
ISO 690:
Chen, A., Shen, Y., Xia, M., Xu, L., Pan, N., Yin, Y., Miao, F., Shen, C., Xie, W., Zhang, J. 2011. Expression of the nonclassical HLA class I and MICA/B molecules in human hepatocellular carcinoma. In NEOPLASMA, vol. 58, no.5, pp. 371-376. 0028-2685.
APA:
Chen, A., Shen, Y., Xia, M., Xu, L., Pan, N., Yin, Y., Miao, F., Shen, C., Xie, W., Zhang, J. (2011). Expression of the nonclassical HLA class I and MICA/B molecules in human hepatocellular carcinoma. NEOPLASMA, 58(5), 371-376. 0028-2685.