In: NEOPLASMA, vol. 57, no. 3
J Brezinova - A Berkova - S Vcelikova - Z Zemanova - S Izakova - I Sarova - H Cechova - J Tajtlova - L Grosova - L Lizcova - E Malinova - M Zemanova - E Cmunt - J Karban - M Trneny - J Schwarz - K Michalova
Detaily:
Rok, strany: 2010, 215 - 221
O článku:
Telomere length was evaluated by terminal repeat fragment method in 66 previously untreated patients with B-chronic lymphocytic leukemia (B-CLL) to ascertain whether telomere shortening was associated with genomic aberrations, immunoglobulin variable heavy chain (IgVH) mutational status, CD38 and ZAP-70 expression, and telomerase activity. Chromosomal aberrations were present in peripheral blood cells of 73% patients (48/66), no difference in telomere length between patients with good and intermediate prognosis according to cytogenetics was found. Association between telomere length and IgVH mutational status, ZAP-70 and CD38 expression was proved as significantly shorter telomeres in patients with unmutated IgVH status (p=0.01) and ZAP-70 positivity (p=0.01) and CD38 positivity (p=0.05) were detected. Telomerase activity was positive in 11 patients out of 21 examined, correlation between telomere length and telomerase activity was found (p=0.05). Telomere length and telomerase activity in combination with other prognostic parameters complete the risk profile of B-CLL patients and might serve for an easy decision on optimal treatment strategy. Keywords: B-chronic lymphocytic leukemia, telomere length, telomerase activity, chromosomal aberrations, prognosis
Ako citovať:
ISO 690:
Brezinova, J., Berkova, A., Vcelikova, S., Zemanova, Z., Izakova, S., Sarova, I., Cechova, H., Tajtlova, J., Grosova, L., Lizcova, L., Malinova, E., Zemanova, M., Cmunt, E., Karban, J., Trneny, M., Schwarz, J., Michalova, K. 2010. Telomere length, molecular cytogenetic findings, and immunophenotypic features in previously untreated patients with B-chronic lymphocytic leukemia. In NEOPLASMA, vol. 57, no.3, pp. 215-221. 0028-2685.
APA:
Brezinova, J., Berkova, A., Vcelikova, S., Zemanova, Z., Izakova, S., Sarova, I., Cechova, H., Tajtlova, J., Grosova, L., Lizcova, L., Malinova, E., Zemanova, M., Cmunt, E., Karban, J., Trneny, M., Schwarz, J., Michalova, K. (2010). Telomere length, molecular cytogenetic findings, and immunophenotypic features in previously untreated patients with B-chronic lymphocytic leukemia. NEOPLASMA, 57(3), 215-221. 0028-2685.