Facebook Instagram Twitter RSS Feed PodBean Back to top on side

Activation of HLA-G expression by 5-aza-2´- deoxycytidine in malignant hematopoetic cells isolated from leukemia patients

In: NEOPLASMA, vol. 56, no. 6
K Polakova - E Bandzuchova - F Sabty - M Mistrik - L Demitrovicova - G Russ
Detaily:
Rok, strany: 2009, 514 - 520
O článku:
Human leukocyte antigen – G (HLA-G) is a non-classical HLA class I antigen with restricted distribution in normal tissues. Ectopic HLA-G expression observed at some pathological circumstances as malignant transformation might be triggered by epigenetic modifications such as DNA demethylation. Recently it was demonstrated that DNA methyltransferase inhibitor 5-aza-2´- deoxycytidine (AdC) induces/enhances HLA-G transcription in many leukemia cell lines of different origin. Here we investigated the effect of AdC on HLA-G expression in malignant hematopoetic cells isolated from patients with acute myeloid leukemia (AML) and chronic lymphocytic leukemia (B-CLL). We detected HLA-G expression in untreated cells from some patients. Nevertheless treatment with 5-aza-2´- deoxycytidine enhanced HLA-G transcription and concomitantly HLA-G protein synthesis in some leukemia cells. Keywords: HLA-G, DNA demethylation, 5-aza-2´- deoxycytidine, AML, B-CLL
Ako citovať:
ISO 690:
Polakova, K., Bandzuchova, E., Sabty, F., Mistrik, M., Demitrovicova, L., Russ, G. 2009. Activation of HLA-G expression by 5-aza-2´- deoxycytidine in malignant hematopoetic cells isolated from leukemia patients. In NEOPLASMA, vol. 56, no.6, pp. 514-520. 0028-2685.

APA:
Polakova, K., Bandzuchova, E., Sabty, F., Mistrik, M., Demitrovicova, L., Russ, G. (2009). Activation of HLA-G expression by 5-aza-2´- deoxycytidine in malignant hematopoetic cells isolated from leukemia patients. NEOPLASMA, 56(6), 514-520. 0028-2685.