In: NEOPLASMA, vol. 55, no. 6
X. Wu
Detaily:
Rok, strany: 2008, 472 - 481
O článku:
Hepatocellular carcinoma (HCC) is a hypervascular tumor, and tumor progression and prognosis is associated with
angiogenesis. Extracellular matrix remodeling and inflammation play important roles in hepatocarcinogenesis. Some
ingredients of extracellular matrix such as endostatin and sulfated polysaccharide, some immunomodulatory agents and
cox-2 inhibitor suppress the angiogenesis of HCC. Because vasculogenic mimicry is associated with high tumor grade,
some differentiation agents are used to inhibit antiagiogenesis. Besides suppressing the proliferation directly, somatostatin
inhibits angiogenesis to suppress growth indirectly. Copper chelator prevents copper from functioning as a cofactor in
angiogenesis. The renin-angiotensin system is frequently activated in patients with chronic liver diseases. Perindopril, an
angiotensin converting enzyme inhibitor, inhibits angiogenesis by reducing vascular endothelial growth factor (VEGF)
production. Kinase inhibitors of VEGF and epidermal growth factor receptors are expected to be of benefit for some patients.
Following transarterial embolisation and/or resection, antiangiogenic therapy could prevent the recurring and metastasis.
Hypoxia enhances the proliferation, suppresses the differentiation and apoptosis, and induces multidrug resistance of HCC.
Because antiangiogenic therapies induce hypoxia, it should be borne in mind the side affects of antiangiogenic therapy.
Because long-acting antiangiogenent are needed to control cancer, it needs more clinical studies to confirm the drug resistance
of antiangiogenetic therapy.
Key words: angiogenesis, hepatocellular carcinoma, hypoxia, vascular endothelial growth factor
Ako citovať:
ISO 690:
Wu, X. 2008. New strategy of antiangiogenic therapy for hepatocellular carcinoma. In NEOPLASMA, vol. 55, no.6, pp. 472-481. 0028-2685.
APA:
Wu, X. (2008). New strategy of antiangiogenic therapy for hepatocellular carcinoma. NEOPLASMA, 55(6), 472-481. 0028-2685.