In: NEOPLASMA, vol. 55, no. 6
O. Babusikova - T. Železníková
Detaily:
Rok, strany: 2008, 501 - 506
O článku:
The cellular diversity of bone marrow samples was studied by using multi-dimensional cluster analysis of six-parametric
flow cytometry data (four CD, forward scatter and side scatter), focusing mainly on acute leukemia blast cells and regeneration
of normal B-cells, hematogones. This approach should enhance the ability to study normal hematopoiesis, and to identify
and monitor hematopoietic disorders. The study was performed on a homogeneous group of patients (mainly children), all
of them after finishing complete therapy for AL, mostly B-ALL. In all of these patients complete pattern of all three
individual Hg stages was present. Maturation spectra of surface immunoglobulin kappa (sIgκ) and lambda (sIgλ) light
chains and IgM, IgA heavy chains in all three stages of Hgs are presented as reliable reports on sIgs as their incidence on
Hgs are scarse and even contradictory. The Ig expression paralles CD20 expression. SIg of light (κ,λ) and heavy (IgM, IgA)
chains were completally absent in stage 1 Hgs and their expression increased through stage 2 to 3; IgM was expressed
similarly. Light Ig chains κ/λ were expressed in a polytypic way. The results completed information on normal maturation
sequence of bone marrow stage 1, 2 and 3 hematogone regeneration in treated acute leukemia patients.
Key words: Acute leukemia, benign B-lymphocyte precursors, hematogones, multiparameter flow cytometry, surface Ig
of light (κ,λ) and heavy (IgM, IgA) chains maturation sequence
Ako citovať:
ISO 690:
Babusikova, O., Železníková, T. 2008. Normal maturation sequence of immunoglobulin light and heavy chains
in hematogone stages 1, 2 and 3 in acute leukemia after treatment. In NEOPLASMA, vol. 55, no.6, pp. 501-506. 0028-2685.
APA:
Babusikova, O., Železníková, T. (2008). Normal maturation sequence of immunoglobulin light and heavy chains
in hematogone stages 1, 2 and 3 in acute leukemia after treatment. NEOPLASMA, 55(6), 501-506. 0028-2685.