In: NEOPLASMA, vol. 55, no. 6
P. Kubatka - V. Sadlonova - K. Kajo - K. Machalekova - D. Ostatnikova - G. Nosalova - Z. Fetisovova
Detaily:
Rok, strany: 2008, 538 - 543
O článku:
Aromatase inhibitor exemestane as a single – agent has no established role in the treatment of premenopausal breast
cancer women. The aim of this study was to evaluate preventive effects of exemestane in the model of premenopausal Nmethyl-
N-nitrosourea – induced mammary carcinogenesis in female rats. Exemestane treatment begun 7 days prior to
carcinogen administration and continued next 12 weeks – till the end of experiment. Exemestane was dietary administered
in two concentrations of 1 mg / 1kg (EXE 1), or 10 mg/1 kg (EXE 10), respectively.
Exemestane increased the tumor frequency by 80.5 % (P=0.034) in the group EXE 1 and by 61.5 % (P=0.045) in the group
EXE 10 in comparison with control animals. In the group EXE 10, the incidence of mammary tumors was increased by
11.5 % (P=0.31) and tumor volume by 41.5 % (P=0.23), also the latency was shortened by 8 days (P=0.078) compared with
controls. In the groups with exemestane, changes in weights and histology of uterus and vagina were not found at the end of
experiment. Exemestane did not alter serum concentrations of estradiol, testosterone and dehydroepiandrosterone. In the group
EXE 10 in comparison with untreated animals, exemestane decreased serum concentrations of triacylglycerols by 9 % (P=0.032),
total cholesterol by 19.5 % (P=0.0002) and cholesterol of low – density and high – density lipoprotein fractions by 41 % (P<0.0001),
or 21.5 % (P=0.0002), respectively. In the group EXE 1, the decrease in cholesterol of low-density lipoprotein fraction by
22.5 % (P=0.0005) was recorded. An increase in food intake (P=0.023) and body weight gain (P=0.036) was found in the group
EXE 10 compared with the control group (P<0.05).
The present study points to apparent tumor – promoting effects of dietary administered exemestane in the model of
premenopausal mammary carcinogenesis in female rats. Exemestane as a steroidal agent indicated androgenic effects on rat
lipid metabolism in this experiment.
Key words: mammary carcinogenesis, rat, chemoprevention, exemestane, aromatase inhibitors.
Ako citovať:
ISO 690:
Kubatka, P., Sadlonova, V., Kajo, K., Machalekova, K., Ostatnikova, D., Nosalova, G., Fetisovova, Z. 2008. Neoplastic effects of exemestane in premenopausal breast cancer model. In NEOPLASMA, vol. 55, no.6, pp. 538-543. 0028-2685.
APA:
Kubatka, P., Sadlonova, V., Kajo, K., Machalekova, K., Ostatnikova, D., Nosalova, G., Fetisovova, Z. (2008). Neoplastic effects of exemestane in premenopausal breast cancer model. NEOPLASMA, 55(6), 538-543. 0028-2685.